{{Short description|Chemical compound}} {{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 461102115 | IUPAC_name = (1''R'',2''S'',8''S'',10''S'',11''S'',14''R'',15''S'',17''S'')-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.0<sup>2,7</sup>.0<sup>11,15</sup>]heptadeca-3,6-dien-5-one | image = Fluorometholone.svg | image_class = skin-invert-image
<!--Clinical data--> | tradename = | Drugs.com = {{drugs.com|monograph|fluorometholone}} | MedlinePlus = a682660 | pregnancy_category = | routes_of_administration = | ATC_prefix = C05 | ATC_suffix = AA06 | ATC_supplemental = {{ATC|D07|AB06}}, {{ATC|D07|XB04}} (combinations), {{ATC|D10|AA01}}, {{ATC|S01|BA07}}
| legal_CA = Rx-only | legal_CA_comment = <ref>{{cite web | title=Product monograph brand safety updates | website=Health Canada | date=February 2024 | url=https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database/label-safety-assessment-update/product-monograph-brand-safety-updates.html | access-date=24 March 2024}}</ref> | legal_status =
<!--Pharmacokinetic data--> | bioavailability = | protein_bound = | metabolism = | elimination_half-life =
<!--Identifiers--> | IUPHAR_ligand = 7079 | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 426-13-1 | PubChem = 9878 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = DB00324 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 9494 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = SV0CSG527L | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D01367 | ChEBI_Ref = {{ebicite|changed|EBI}} | ChEBI = 31625 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 1200600 <!--Chemical data--> | C=22 | H=29 | F=1 | O=4 | smiles = O=C(C)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](C)C[C@H]4[C@@H]2CC3)C)C | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = FAOZLTXFLGPHNG-KNAQIMQKSA-N | synonyms = <small>(6''S'',8''S'',9''R'',10''S'',11''S'',13''S'',14''S'',17''R'')-17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[''a'']phenanthren-3-one </small> }}
'''Fluorometholone''' (INN, BAN, JAN) (brand names '''Efflumidex''', '''Flucon''', '''FML Forte''', '''FML''', others), also known as '''6α-methyl-9α-fluoro-11β,17α-dihydroxypregna-1,4-diene-3,20-dione''', is a synthetic glucocorticoid which is used in the treatment of inflammatory eye diseases.<ref name="Elks2014">{{cite book | vauthors = Elks J |title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA566|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=566–}}</ref><ref name="IndexNominum2000">{{cite book|title=Index Nominum 2000: International Drug Directory|url=https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA458|date=January 2000|publisher=Taylor & Francis|isbn=978-3-88763-075-1|pages=458–}}</ref><ref name="MortonHall2012">{{cite book| vauthors = Morton IK, Hall JM |title=Concise Dictionary of Pharmacological Agents: Properties and Synonyms|url=https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA123|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-94-011-4439-1|pages=123–}}</ref> The C17α acetate ester, fluorometholone acetate (brand name Flarex), is also a glucocorticoid and is used for similar indications.<ref name="Elks2014" /><ref name="IndexNominum2000" /><ref name="MortonHall2012" />
==References== {{Reflist}}
{{Glucocorticoids and antiglucocorticoids}} {{Vasoprotectives}} {{Glucocorticoid receptor modulators}} {{Progesterone receptor modulators}} {{Xenobiotic-sensing receptor modulators}}
Category:Glucocorticoids Category:Halohydrins Category:Organofluorides Category:Drugs developed by Novartis Category:Pregnanes Category:Progestogens
{{cardiovascular-drug-stub}} {{dermatologic-drug-stub}}