{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Nidogen-1''' ('''NID-1'''), formerly known as '''entactin''', is a protein that in humans is encoded by the ''NID1'' gene.<ref name="pmid2471408">{{cite journal | vauthors = Olsen DR, Nagayoshi T, Fazio M, Mattei MG, Passage E, Weil D, Timpl R, Chu ML, Uitto J | title = Human nidogen: cDNA cloning, cellular expression, and mapping of the gene to chromosome Iq43 | journal = Am. J. Hum. Genet. | volume = 44 | issue = 6 | pages = 876–85 |date=June 1989 | pmid = 2471408 | pmc = 1715653 }}</ref><ref name="pmid7557988">{{cite journal | vauthors = Zimmermann K, Hoischen S, Hafner M, Nischt R | title = Genomic sequences and structural organization of the human nidogen gene (NID) | journal = Genomics | volume = 27 | issue = 2 | pages = 245–50 |date=May 1995 | pmid = 7557988 | doi = 10.1006/geno.1995.1038 }}</ref> Both nidogen-1 and nidogen-2 are essential components of the basement membrane alongside other components such as type IV collagen, proteoglycans (heparan sulfate and glycosaminoglycans), laminin<ref name="pmid8208674">{{cite journal | vauthors = Smith J, Ockleford CD | title = Laser scanning confocal examination and comparison of nidogen (entactin) with laminin in term human amniochorion | journal = Placenta | volume = 15 | issue = 1 | pages = 95–106 |date=January 1994 | pmid = 8208674 | doi = 10.1016/S0143-4004(05)80240-1 }}</ref> and fibronectin.<ref name="pmid7904354">{{cite journal | vauthors = Ockleford CD, Bright N, Hubbard A, D'Lacey C, Smith J, Gardiner L, Sheikh T, Albentosa M, Turtle K | title = Micro-Trabeculae, Macro-Plaques or Mini-Basement Membranes in Human Term Fetal Membranes? | journal = Phil. Trans. R. Soc. Lond. B | volume = 342 | issue = 1300 | pages = 121–136 |date=October 1993 | pmid = 7904354| doi = 10.1098/rstb.1993.0142 }}</ref>
== Function ==
Nidogen-1 is a member of the nidogen family of basement membrane glycoproteins. The protein interacts with several other components of basement membranes. Structurally it (along with perlecan) connects the networks formed by collagens and laminins to each other.<ref name="pmid19355968">{{cite journal | vauthors = Yurchenco PD, Patton BL | title = Developmental and pathogenic mechanisms of basement membrane assembly | journal = Curr. Pharm. Des. | volume = 15 | issue = 12 | pages = 1277–94 | year = 2009 | pmid = 19355968 | pmc = 2978668 | doi = 10.2174/138161209787846766}}</ref> It may also play a role in cell interactions with the extracellular matrix.<ref>{{cite web | title = Entrez Gene: NID1 nidogen 1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=4811}}</ref><ref name="pmid9686320">{{cite journal | vauthors = Yi XY, Wayner EA, Kim Y, Fish AJ | title = Adhesion of cultured human kidney mesangial cells to native entactin: role of integrin receptors | journal = Cell Adhes. Commun. | volume = 5 | issue = 3 | pages = 237–48 |date=March 1998 | pmid = 9686320 | doi = 10.3109/15419069809040294}}</ref>
== Clinical significance == Mutations in ''NID1'' cause autosomal dominant Dandy–Walker malformation with occipital encephalocele (ADDWOC).<ref>{{Cite web|url=https://www.omim.org/entry/609222|title=OMIM Entry - % 609222 - DANDY-WALKER MALFORMATION WITH OCCIPITAL CEPHALOCELE, AUTOSOMAL DOMINANT; ADDWOC|website=www.omim.org|access-date=2020-01-06}}</ref><ref>{{Cite journal|last1=McNiven|first1=Vanda|last2=Ito|first2=Yoko A.|last3=Hartley|first3=Taila|last4=Kernohan|first4=Kristin|last5=Miller|first5=Elka|last6=Care4Rare Canada|last7=Armour|first7=Christine M.|date=May 2019|title=NID1 variant associated with occipital cephaloceles in a family expressing a spectrum of phenotypes|journal=American Journal of Medical Genetics. Part A|volume=179|issue=5|pages=837–841|doi=10.1002/ajmg.a.61095|issn=1552-4833|pmid=30773799|s2cid=73507129}}</ref>
== Interactions ==
Nidogen-1 has been shown to interact with FBLN1.<ref name="pmid9299350">{{cite journal | vauthors = Adam S, Göhring W, Wiedemann H, Chu ML, Timpl R, Kostka G | title = Binding of fibulin-1 to nidogen depends on its C-terminal globular domain and a specific array of calcium-binding epidermal growth factor-like (EG) modules | journal = J. Mol. Biol. | volume = 272 | issue = 2 | pages = 226–36 |date=September 1997 | pmid = 9299350 | doi = 10.1006/jmbi.1997.1244 }}</ref><ref name="pmid9278415">{{cite journal | vauthors = Tran H, VanDusen WJ, Argraves WS | title = The self-association and fibronectin-binding sites of fibulin-1 map to calcium-binding epidermal growth factor-like domains | journal = J. Biol. Chem. | volume = 272 | issue = 36 | pages = 22600–6 |date=September 1997 | pmid = 9278415 | doi = 10.1074/jbc.272.36.22600| doi-access = free }}</ref><ref name="pmid8354280">{{cite journal | vauthors = Pan TC, Kluge M, Zhang RZ, Mayer U, Timpl R, Chu ML | title = Sequence of extracellular mouse protein BM-90/fibulin and its calcium-dependent binding to other basement-membrane ligands | journal = Eur. J. Biochem. | volume = 215 | issue = 3 | pages = 733–40 |date=August 1993 | pmid = 8354280 | doi = 10.1111/j.1432-1033.1993.tb18086.x| doi-access = free }}</ref>
==References== {{reflist}}
==Further reading== {{refbegin | 2}} *{{cite journal | vauthors=Chung AE, Durkin ME |title=Entactin: structure and function. |journal=Am. J. Respir. Cell Mol. Biol. |volume=3 |issue= 4 |pages= 275–82 |year= 1990 |pmid= 2119632 |doi= 10.1165/ajrcmb/3.4.275}} *{{cite journal | vauthors=Yurchenco PD, Schittny JC |title=Molecular architecture of basement membranes. |journal=FASEB J. |volume=4 |issue= 6 |pages= 1577–90 |year= 1990 |pmid= 2180767 |doi= 10.1096/fasebj.4.6.2180767|doi-access=free |s2cid=18724722 }} {{refend}}
==External links== * {{MeshName|Nidogen}} * {{PDBe-KB2|P10493|Mouse Nidogen-1}}
{{PDB Gallery|geneid=4811}}
Category:Human proteins Category:Glycoproteins Category:Extracellular matrix proteins Category:Genes on human chromosome 1