Dyserythropoiesis

{{Infobox medical condition (new) | name = | synonym = | image = Iron-deficiency Anemia, Peripheral Blood Smear (4422704616).jpg | image_size = | alt = | caption = A peripheral blood smear of a patient with iron-deficiency anemia, an example of an acquired dyserythropoiesis | pronounce = | specialty =  | symptoms = | complications = | onset = | duration = | types = | causes = | risks = | diagnosis = | differential = | prevention = | treatment = | medication = | prognosis = | frequency = | deaths = }}

'''Dyserythropoiesis''' refers to the defective development of red blood cells, also called erythrocytes.<ref name="Orkin Nathan 2009 p. 360">{{cite book | last1=Orkin | first1=S.H. | last2=Nathan | first2=D.G. | title=Nathan and Oski's Hematology of Infancy and Childhood | publisher=Saunders/Elsevier | series=ClinicalKey 2012 | issue=v. 1 | year=2009 | isbn=978-1-4160-3430-8 | url=https://books.google.com/books?id=_9CmOIvgJm4C&pg=PA360 | access-date=2017-10-31 | page=360}}</ref> This problem can be congenital, acquired, or inherited.<ref name="Shinton 2007 p. 267">{{cite book | last=Shinton | first=N.K. | title=Desk Reference for Hematology, Second Edition | publisher=CRC Press | year=2007 | isbn=978-1-4200-0512-7 | url=https://books.google.com/books?id=b0aw2SLzZQ8C&pg=PA267 | access-date=2017-10-31 | page=267}}</ref> Some red blood cells may be destroyed within the bone marrow during the maturation process, whereas others can enter the circulation with abnormalities.<ref name="Hoffbrand Catovsky Tuddenham 2008 p. 202">{{cite book | last1=Hoffbrand | first1=A.V. | last2=Catovsky | first2=D. | last3=Tuddenham | first3=E.G.D. | title=Postgraduate Haematology | publisher=Wiley | year=2008 | isbn=978-1-4051-4353-0 | url=https://books.google.com/books?id=jYMT6FOCLUgC&pg=PA203 | language=de | access-date=2017-10-31 | page=202}}</ref> These abnormalities can be functional and/or morphological, which can lead to anemia since there may be increased turnover of red blood cells.<ref name="Orkin Nathan 2009 p. 360"/><ref name="Shinton 2007 p. 267"/> There are a number of diseases that cause dyserythropoiesis. Congenital/inherited causes include congenital dyserythropoietic anemia, thalassemia, pyruvate kinase deficiency, hereditary pyropoikilocytosis, and abetalipoproteinemia.<ref name="Shinton 2007 p. 267"/> Acquired causes include nutrient deficiency/malnutrition (e.g. cobalamine, folate, and iron), myelodysplasia, HIV infection, and certain medications (e.g. zidovudine).<ref name="Shinton 2007 p. 267"/>

==References== {{reflist}}

Category:Red blood cell disorders