DNA polymerase III subunit gamma/tau

{{Infobox protein family | Symbol = DNA_pol_III_sug/sutau | Name = DNA polymerase III tau subunit V interacting with alpha | image = | width = | caption = solution structure of the c-terminal 14 kda domain of the tau subunit from escherichia coli dna polymerase iii | Pfam = PF12170 | Pfam_clan = | InterPro = IPR012763 | SMART = | PROSITE = | MEROPS = | SCOP = | TCDB = | OPM family = | OPM protein = | CAZy = | CDD = }} The '''τ and γ subunits''' are part of the DNA polymerase III holoenzyme of prokaryotes. The protein family is characterized by the well-conserved first N-terminal domain, approx. 365 amino acids. The eukaryotic equivalent to the DNA clamp loader is replication factor C, with the subunits RFC1, RFC2, RFC3, RFC4, and RFC5.

The domain is also found in plants as gene STICHEL (STI), with similarity to cyanobacterial sequences.<ref>{{cite journal | vauthors = Khan H, Parks N, Kozera C, Curtis BA, Parsons BJ, Bowman S, Archibald JM | title = Plastid genome sequence of the cryptophyte alga Rhodomonas salina CCMP1319: lateral transfer of putative DNA replication machinery and a test of chromist plastid phylogeny | journal = Molecular Biology and Evolution | volume = 24 | issue = 8 | pages = 1832–1842 | date = August 2007 | pmid = 17522086 | doi = 10.1093/molbev/msm101 | doi-access = free }}</ref> However, STI in plants is nuclear-localized and does not participate in genome duplication. It seems to instead regulate branching.<ref>{{cite journal | vauthors = Ilgenfritz H, Bouyer D, Schnittger A, Mathur J, Kirik V, Schwab B, Chua NH, Jürgens G, Hülskamp M | display-authors = 6 | title = The Arabidopsis STICHEL gene is a regulator of trichome branch number and encodes a novel protein | journal = Plant Physiology | volume = 131 | issue = 2 | pages = 643–655 | date = February 2003 | pmid = 12586888 | doi = 10.1104/pp.014209 | pmc = 166840 | s2cid = 31931499 }}</ref>

== References == {{Reflist}}

Category:Bacterial proteins Category:Protein families Category:DNA replication