{{Cleanup rewrite|date=March 2024}} {{Short description|Chemical derivative of chondrin}} A '''chondroitin''', as the sulfate, is a component of bamacan, a proteoglycan (sugar-protein conjugate) that comprises some membranes.<ref>{{cite journal |last1=Iozzo |first1=Renato V. |title=MATRIX PROTEOGLYCANS: From Molecular Design to Cellular Function |journal=Annual Review of Biochemistry |date=1998 |volume=67 |pages=609–652 |doi=10.1146/annurev.biochem.67.1.609 |pmid=9759499 }}</ref> Chondroitin is a chondrin derivative.<ref>{{MeshName|Chondroitin}}</ref>
Types include: * Chondroitin sulfate * Dermatan sulfate
Chondroitin as a supplement is now commonly used (often in combination with glucosamine) in treating the joint disease of osteoarthritis.<ref name=":0">{{Cite journal|last1=Vasiliadis|first1=Haris S|last2=Tsikopoulos|first2=Konstantinos|date=2017|title=Glucosamine and chondroitin for the treatment of osteoarthritis|journal=World Journal of Orthopedics|language=en|volume=8|issue=1|pages=1–11|doi=10.5312/wjo.v8.i1.1|issn=2218-5836|pmc=5241539|pmid=28144573 |doi-access=free }}</ref> In contrast to the symptomatic treatments, chondroitin can modify the progression of a disease process in the patient which it can be used as an alternative medicine.<ref name=":0" /> Chondroitin's effect toward the articular cartilage integrity as it is part of the proteoglycan molecules.<ref name=":1">{{Cite journal|last=Tavakol|first=Kamran|title=Glucosamine and Chondroitin for Treatment of Osteoarthritis: A Systematic Quality Assessment and Meta-analysis|journal=Physical Therapy|volume=80|issue=10|page=1049}}</ref> The cartilage proteoglycan synthesis can speed up as chondroitin is going through the pathway of the alimentary canal.<ref name=":1" /> Research has been conducted to show the effectiveness of chondroitin and results indicate that it helps to manage pain in knee and hip, slow down the progression and also recovery.<ref>{{Cite journal|last1=Zhu|first1=Xiaoyue|last2=Sang|first2=Lingli|last3=Wu|first3=Dandong|last4=Rong|first4=Jiesheng|last5=Jiang|first5=Liying|date=December 2018|title=Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials|journal=Journal of Orthopaedic Surgery and Research|language=en|volume=13|issue=1|pages=170|doi=10.1186/s13018-018-0871-5|issn=1749-799X|pmc=6035477|pmid=29980200 |doi-access=free }}</ref> However, the effectiveness of the drugs is still doubtful.<ref name=":1" />
==References== {{reflist}}
{{Glycosaminoglycans}}
Category:Glycosaminoglycans