Not to be confused with Lacing (drugs)#Commonly laced substances.

Polysubstance use or multisubstance use is the use of combinations of psychoactive substances with both legal and illegal substances. This page lists polysubstance combinations that are entheogenic, recreational, or off-label indicated use of pharmaceuticals. For example, the over-the-counter motion sickness combination drug dimenhydrinate (8-chlorotheophylline/diphenhydramine) is occasionally used in higher doses as a deliriant. The prescription medicine Adderall (dextroamphetamine sulfate/amphetamine sulfate/dextroamphetamine saccharate/amphetamine aspartate monohydrate) is also frequently used recreationally. However, using non-prescribed drugs, using non-prescribed dose regimen, can cause polysubstance dependence, or combined drug intoxication which may lead to deaths.

Table

To avoid an excessively long list, the table below only lists recreational drug combinations that are not patent medicine.

Drug 1Drug 2Drug 3Drug 4Polysubstance slang,[1][2][3]
or brand name		Intoxication nameComment
Any dissociativeAny dissociativeVoid flipVoid flipping
Any dissociativeDMTDime bar, angel flipDimension flipping, angel flipping
Any depressantAny stimulantSpeedball, powerball, over and underPowerballing, speedballing[4]
Any pharmaceuticalAny pharmaceuticalPolypharmacyPharming [citation needed]Polypharmacy is most commonly defined as the use of five or more medications daily by an individual.[5] However, the definition of polypharmacy is still debated and can vary from two to 11 concurrent medications.[5]
Any drugCannabisAmp joint[6]
Any β-Carboline
containing plant (e.g.
Banisteriopsis caapi
or Peganum harmala)		DMTAyahuasca, ChangaAyahuasca is drunk. Changa is smoked or vaped.
Any antiretroviral drugBlack tar heroinWhoonga, Nyaope [7]Widespread use in South Africa. Whoonga is classically reputed to be a combination of heroin with antiretroviral drugs such as ritonavir and/or efavirenz, often combined with additional drugs such as cannabis or hashish, methamphetamine and/or methaqualone
Any BenzodiazepinePsilocybin or psilocybin mushroomsWarp TripWarping / Warp TrippingWhen taken recreationally, a combination of benzodiazepine and psilocybin may soothe some of the more extreme negative effects often experienced during the peak and comedown phases of a psychedelic trip. Although benzodiazepines do not counteract the hallucinogenic and euphoric sensations caused by Psilocybin (commonly found in psilocybin mushrooms), they are sometimes administered by medical professionals to mitigate symptoms of a "bad trip." This practice helps to gradually relieve overactive sensory responses and induces relaxation in the individual, easing their mental state.[8]
Any deliriant or diphen­hydramineMDMA or PsychedelicsNightmare flipNightmare flipping
2C-B or the closely related 2C-xLSD or any of the LysergamidesMDMA or any Empathogen-entactogenAli flip[9]Ali flipping[9]

This combination starts as a classic candyflip and ends in a Nexus flip. The LSD is taken first, followed by the MDMA 4 hours later and then 2C-B is taken 2 hours after the MDMA (i.e. 6 hours after the LSD ).

MDMA can be replaced by 6-APB, 5-APB, 6-MAPB or 5-MAPB, in this case the Empathogen is taken 2 hours after the LSD, while 2C-B may be replaced by 2C-C, 2C-D or 2C-B-FLY.

This combination's goal is to prolong the empathogenic effects of MDMA and the psychedelic effects of LSD. The idea is to be able to experience an enhanced "Candyflipping" with a twist in the end and a smoother comedown. The whole experience is long-lasting and can be too intense for some individuals as all of these molecules synergize and potentiate each other.

2C-B or the closely related 2C-xMescalineMDMA or any Empathogen-entactogenSelma flip[10][11][9]Selma flipping[12][9]
2C-BMDMANexus flip[12][11]Nexus flipping[12][11]The MDMA is often taken first and the 2C-B after the end of the MDMA peak (h+2/h+2.½). The 2C-B is supposed to help the empathogenic effect of the MDMA last longer.
2C-BDXMNexuswalk[13]NexuswalkNexus (slang for 2C-B) + Robowalk (slang for walking on DXM), similar to Nexusflipping
2C-BLSDThere is no official name for this combination; when an empathogen like MDMA is added to this combination, it becomes an Ali Flip.
2C-ELSDMDMAHaychmaich flip[4]Haychmaich flipping
2C-P2C-EMeskini TripMeskini Tripping
2C-EMDMA or any Empathogen-entactogen2C-B or the closely related 2C-xIlias flip[12][11]Ilias flipping[12][11]The Ilias Flip inspired by the Ali Flip[9] with the use of 2C-E instead of LSD, it can have effects similar to a Selma Flip but with a shorter duration. Be careful with this combination, as 2C-E can have a heavy body load and is different from other 2C-x drugs.
2C-ELSD or closely related LysergamidesMDMA or any Empathogen2C-B or closely related 2C-xAlias Flip[9]Alias flipping[9]The Alias flip is a very powerful mix between an Elias flip and an Ali flip.[9] The idea is to take substances in this order to maximize the duration of 2C-E with the LSD taken one hour after 2C-E.
2C-B-FlyMDMA or any Empathogen-entactogen2C-B or the closely related 2C-xIvan flip[12][11]Ivan flipping[12][11]The Ivan Flip inspired by the Ali Flip[9] with the use of 2C-B-Fly instead of LSD, it can have effects similar to a Selma Flip as 2C-B-Fly is closely related to Mescaline with a shorter duration. Be careful with this combination, as 2C-B-Fly can have a heavy body load and is different from other 2C-x drugs as it is part of the FLY (psychedelics) family.
2C-B4-HO-METFlixxie FlipFlixxie Flipping2C-B taken 40-50 minutes prior to the 4-HO-MET in order to align the peaks. It is extremely visual and moderately low headspace but headspace can increase with increased dosages and can lead to powerful spiritual combinations. Similar to a 2C-T-7 experience.
AlcoholCaffeineCaffeinated alcoholic drinkIrish Coffee
AlcoholCannabis Sonechka flipSonechka FlippingOften 40% alcohol and subsequent smoking of cannabis in the process of sexual intercourse at will, but also apply to the consumption of less alcohol-containing drinks
AlcoholCocaineSnow-coneSnow-coningEthanol is metabolized into cocaethylene[14]
AlcoholMDMATipsy flipTipsy flippingIt may be dangerous
AlcoholNicotineNicotiniA nicotini is any alcoholic drink which includes nicotine as an ingredient. Nicotine replacement therapy products such as mouth spray may be used.
AmphetamineBarbituratesInbetweens[15] Bam
AmphetamineCannabisLSDHippie heart attack [citation needed]
AmphetamineCocaineSnow seals
AmphetamineHeroinBombido[15]
AmphetamineXanaxOrange Dream BlossomCloud RushThe combination is crushed together and insufflated
BelladonnaHashishAlamout black hash[4]Mixed
CaffeineCannabisHippie-speedball[16][17]Hippie-speedballing
CaffeineDiphen­hydramineSleep walkSleepwalking
CaffeineMeth­amphetamineYa ba, biker's coffee, kamikaze
Cacao beanMagic mushroomAztec use of entheogens. Conventional defatted cocoa dissolved in fat may be used instead of whole beans.
CBDTHCLow to moderate doses of CBD might reduce some of the paranoia, anxiety,[18] and reduction of hippocampal volumes that the current high potency THC marijuana (in the last decades, THC content increased and CBD content decreased) can cause, if the CBD substitutes a part of the THC dose.[19][20][21] Low doses of Kanna might also help counteract the anxiety.[22][23]
CannabisCocoa solidsCannabis-infused brownieCannabis edible
CannabisCrack cocaineCrack weed (less known: Buddha, caviar, champagne, chronic, cocktail, dirty joint, fry daddy, gimmie, gremmies, juice joint, lace, oolies, p dog, primo, thirty eight, torpedo, turbo, wollie, yeola)[24]Cocoa puffs, splitting
CannabisCrack cocaineHeroinMajor Pronin, El Diablo
CannabisCrack cocainePCPJim Jones
CannabisDamianaDamiana and other herbs can be used as a tobacco alternative for rolling joints.[25]
CannabisDXMNicotineCandy blunt
CannabisHeroin or opiumA-bomb, Atom bomb, stuff[4]
CannabisMDMAStoner flipStoner flipping
CannabisKetamineStoner Kitty
CannabisKetamineCocaineSimmeredGetting Simmered
CannabisNicotineBlunt, joint, spliff, JonkoA rolled cannabis cigarette usually made with rolling paper. A blunt is a cigar hollowed out and filled with cannabis. It is rolled with the tobacco-leaf "wrapper" from an inexpensive cigar. Blunts take their name from Phillies Blunt brand cigars.
CannabisOpiumDemetra
CannabisPCPWet (less known: Bionic, clickums, donk, illies, leak, love leaf, lovelies, parsley, supergrass, superweed, wet, zoom)IllingWet is cannabis dipped in PCP [26]
CannabisPCPNicotineWet blunt, dust blunt, dusted blunt, Kendrick Lamar bluntIlling
CocaineHeroinSnowball. Other names: Belushi, bombita, murder one, whiz bangSnowballing
CocaineHeroinLSDFrisco special[4]
CocaineHeroinNicotineFlamethrower, primosCigarette laced with cocaine and heroin
CocaineKetamineCake, CK1, Calvin Klein, Cable, Party bag, Coquette
CocaineKetamineMDMAKetamollicaine
CocaineLSDMDMACandy-flip on a stringCandy-flipping on a stringHigh risk on health
CocaineMDMASugar flipSugar flipping
CocaineMorphineC & M
CocainePCPSpace, whack
CocaineWineCoca wineEthanol is metabolized into cocaethylene
CocaineQuetiapineQ-ball
CodeineGlutethimidePancakes and syrupsCombination of glutethimide and codeine cough syrup
CodeinePromethazineLean, purple drank, oil
Diphen­hydramineDXMOTC flip, counterflippingOTC flipping, robowalking on a string
DMTLSDCosmo flip, Meadow flipCosmo flipping, meadow flipping
DMTLSDPsilocybin or psilocybin mushroomSuper flipSuper flipping
DMTMAOIsPharmahuasca
DMTPsilocybin or psilocybin mushroomTerence flipTerence flipping
DMTNitrous oxideDimension flipDimension flippingNitrous oxide can, allegedly, briefly multiply the effects of psychedelics like DMT or NB-DMT[27]
DMTAlcoholSpyder, Spyder spinSpyder spinning
DXMLSDLSDXM
DXMMDMARobo flipRobo flipping
DXMPsilocybin or psilocybin mushroomCherry-bombCherry-bombing
FentanylHeroinBirria, chiva loca, Facebook
Fentanyl
(and/or heroin)		XylazineTranq, Tranq dope
FentanylLSDSpace FentBlackholing
GHBMDMAGamma flipGamma flipping
GHBMeth­amphetamineCherry meth
HashishCrack cocaineDouble zero
HashishLSDRoyal temple ball
HashishOpiumBlack hash, black Russian
HeroinMeth­amphetamineGoofball[28]
HeroinMorphineNew Jack swing
HeroinPCPAlien sex fiend[4]
KetamineLSDDolphin flipDolphin flipping
KetamineMDMAKitty flip,[29] MK-ultraKitty flipping
KetaminePsilocybin or Psilocybin mushroomsFunky flip, chonkFunky flipping, chonking
LSDCaffeineHoffmann FlipHoffmann flipping
LSDKetamineMDMAHoly Trident, Martin Luther King flip, Galaxy flipHoly Tridenting, Martin Luther King flipping, Galaxy Flipping
LSDMDMACandy flip[12][11]Candy flipping[9][12][11]Generally, the MDMA is taken approximately 4 hours after the LSD ingestion. A variant of this combination consists of adding 2C-B on top of it before the Candy Flip starts coming down and it transforms it into a longer experience known as an Ali Flip.[9]
LSDMDMAPsilocybin or psilocybin mushroomJedi flip,[29] twilight flipJedi flipping, twilight flipping
LSDMDMAMushroomsKetamineQuantum FlipQuantum Flipping
LSDNitrous oxideGasidNitrous oxide can, allegedly, briefly multiply the effects of psychedelics like LSD.[27]
LSDPCPBlack acid
LSDMDMAKetamineSwalap FlipSwalaped
LSDPsilocybin or psilocybin mushroomGod's flesh, Soul Bomb, Alice,[4] Wizard flipWizard flipping
LSDDissociatives, especially long-lasting ones such as DMXE and/or DCK.MDMAPixie flipPixie flipping
LSDDissociatives, especially long-lasting ones such as DMXE and/or DCK.MDMADMTBehind the curtain, portal flipClimbing behind the curtain, portal flipping
LSDMetocin (4-HO-MET)Neon Bomb, Diamond BombNeon Bombing, Diamond Bombing
MDMAMescaline or psychoactive cactusLove flip, love tripLove flippingWhen 2C-B is added to this combination it becomes a Selma Flip.
MDMAMeth­amphetamineTrailer flipTrailer flipping
MDMADMTShaman flip, time flipShaman flipping, time flipping
MDMANitrous oxideNox
MDMAOpiatesPoppy flipPoppy flipping
MDMAPCPDomex, elephant flipElephant flipping
MDMAPsilocybin or psilocybin mushroomHippie flipHippie flipping[30]
MDMA or any Empathogen-entactogen5-MeO-MiPT2C-B or the closely related 2C-xStella Flipping[12][11]Stella Flip[12][11]
MDMAViagra (or other PDE5 inhibitors such as Cialis or Levitra)Sextasy, trail mix, cocktail pills[31]
MDMAXanaxZen flipZen flipping
Meth­amphetamineSecobarbital, or other barbituratesPoor man's speedball
MethamphetamineAlpha-PVPCartel meth
MethaqualoneCannabisWhite pipe[32][33]Ingested by smoking. Popular in South Africa, elsewhere in Africa, and in India.[33]
PentazocineTripelannamineT's and Blues[34]
VenlafaxineMirtazepineCalifornia rocket fuel

See also

References

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