S100A6

{{Short description|Human protein and coding gene}} {{Infobox_gene}} '''S100 calcium-binding protein A6''' ('''S100A6''') is a protein that in humans is encoded by the ''S100A6'' gene.<ref name="entrez">{{cite web | title = Entrez Gene: S100A6 S100 calcium binding protein A6| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=6277}}</ref>

== Function ==

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.<ref name="entrez" />

== Interactions ==

S100A6 has been shown to interact with S100B<ref name=pmid10913138>{{cite journal | vauthors = Deloulme JC, Assard N, Mbele GO, Mangin C, Kuwano R, Baudier J | title = S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo | journal = J. Biol. Chem. | volume = 275 | issue = 45 | pages = 35302–10 | date = November 2000 | pmid = 10913138 | doi = 10.1074/jbc.M003943200 | doi-access = free }}</ref><ref name=pmid9925766>{{cite journal | vauthors = Yang Q, O'Hanlon D, Heizmann CW, Marks A | title = Demonstration of heterodimer formation between S100B and S100A6 in the yeast two-hybrid system and human melanoma | journal = Exp. Cell Res. | volume = 246 | issue = 2 | pages = 501–9 | date = February 1999 | pmid = 9925766 | doi = 10.1006/excr.1998.4314 }}</ref> and SUGT1.<ref name=pmid12746458>{{cite journal | vauthors = Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J | title = Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins | journal = J. Biol. Chem. | volume = 278 | issue = 29 | pages = 26923–8 | date = July 2003 | pmid = 12746458 | doi = 10.1074/jbc.M211518200 | doi-access = free }}</ref>

==Pathology== S100A6 to be reported as possible diagnostic marker of papillary thyroid carcinoma.<ref>{{cite journal | vauthors = Sofiadis A, Dinets A, Orre LM, Branca RM, Juhlin CC, Foukakis T, Wallin G, Höög A, Hulchiy M, Zedenius J, Larsson C, Lehtiö J | title = Proteomic study of thyroid tumors reveals frequent up-regulation of the Ca2+ -binding protein S100A6 in papillary thyroid carcinoma | journal = Thyroid | volume = 20 | issue = 10 | pages = 1067–76 | date = October 2010 | pmid = 20629554 | doi = 10.1089/thy.2009.0400 }}</ref>

== References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Schäfer BW, Heizmann CW | title = The S100 family of EF-hand calcium-binding proteins: functions and pathology | journal = Trends Biochem. Sci. | volume = 21 | issue = 4 | pages = 134–40 | year = 1996 | pmid = 8701470 | doi = 10.1016/S0968-0004(96)80167-8 }} * {{cite journal | vauthors = Minami H, Tokumitsu H, Mizutani A, Watanabe Y, Watanabe M, Hidaka H | title = Specific binding of CAP-50 to calcyclin | journal = FEBS Lett. | volume = 305 | issue = 3 | pages = 217–9 | year = 1992 | pmid = 1299619 | doi = 10.1016/0014-5793(92)80671-3 | doi-access = free }} * {{cite journal | vauthors = Engelkamp D, Schäfer BW, Erne P, Heizmann CW | title = S100 alpha, CAPL, and CACY: molecular cloning and expression analysis of three calcium-binding proteins from human heart | journal = Biochemistry | volume = 31 | issue = 42 | pages = 10258–64 | year = 1992 | pmid = 1384693 | doi = 10.1021/bi00157a012 }} * {{cite journal | vauthors = Tomida Y, Terasawa M, Kobayashi R, Hidaka H | title = Calcyclin and calvasculin exist in human platelets | journal = Biochem. Biophys. Res. Commun. | volume = 189 | issue = 3 | pages = 1310–6 | year = 1992 | pmid = 1482346 | doi = 10.1016/0006-291X(92)90216-8 }} * {{cite journal | vauthors = Filipek A, Gerke V, Weber K, Kuźnicki J | title = Characterization of the cell-cycle-regulated protein calcyclin from Ehrlich ascites tumor cells. Identification of two binding proteins obtained by Ca2(+)-dependent affinity chromatography | journal = Eur. J. Biochem. | volume = 195 | issue = 3 | pages = 795–800 | year = 1991 | pmid = 1999197 | doi = 10.1111/j.1432-1033.1991.tb15768.x | doi-access = free }} * {{cite journal | vauthors = Murphy LC, Murphy LJ, Tsuyuki D, Duckworth ML, Shiu RP | title = Cloning and characterization of a cDNA encoding a highly conserved, putative calcium binding protein, identified by an anti-prolactin receptor antiserum | journal = J. Biol. Chem. | volume = 263 | issue = 5 | pages = 2397–401 | year = 1988 | doi = 10.1016/S0021-9258(18)69220-8 | pmid = 2448309 | doi-access = free }} * {{cite journal | vauthors = Gabius HJ, Bardosi A, Gabius S, Hellmann KP, Karas M, Kratzin H | title = Identification of a cell cycle-dependent gene product as a sialic acid-binding protein | journal = Biochem. Biophys. Res. Commun. | volume = 163 | issue = 1 | pages = 506–12 | year = 1989 | pmid = 2775283 | doi = 10.1016/0006-291X(89)92166-9 }} * {{cite journal | vauthors = Ferrari S, Calabretta B, deRiel JK, Battini R, Ghezzo F, Lauret E, Griffin C, Emanuel BS, Gurrieri F, Baserga R | title = Structural and functional analysis of a growth-regulated gene, the human calcyclin | journal = J. Biol. Chem. | volume = 262 | issue = 17 | pages = 8325–32 | year = 1987 | doi = 10.1016/S0021-9258(18)47567-9 | pmid = 3036810 | doi-access = free | hdl = 11380/811306 | hdl-access = free }} * {{cite journal | vauthors = Calabretta B, Battini R, Kaczmarek L, de Riel JK, Baserga R | title = Molecular cloning of the cDNA for a growth factor-inducible gene with strong homology to S-100, a calcium-binding protein | journal = J. Biol. Chem. | volume = 261 | issue = 27 | pages = 12628–32 | year = 1986 | doi = 10.1016/S0021-9258(18)67137-6 | pmid = 3755724 | doi-access = free | hdl = 11380/811299 | hdl-access = free }} * {{cite journal | vauthors = Schäfer BW, Wicki R, Engelkamp D, Mattei MG, Heizmann CW | title = Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family | journal = Genomics | volume = 25 | issue = 3 | pages = 638–43 | year = 1995 | pmid = 7759097 | doi = 10.1016/0888-7543(95)80005-7 }} * {{cite journal | vauthors = Engelkamp D, Schäfer BW, Mattei MG, Erne P, Heizmann CW | title = Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 90 | issue = 14 | pages = 6547–51 | year = 1993 | pmid = 8341667 | pmc = 46969 | doi = 10.1073/pnas.90.14.6547 | bibcode = 1993PNAS...90.6547E | doi-access = free }} * {{cite journal | vauthors = Filipek A, Wojda U | title = p30, a novel protein target of mouse calcyclin (S100A6) | journal = Biochem. J. | volume = 320 ( Pt 2) | issue = Pt 2 | pages = 585–7 | year = 1996 | doi = 10.1042/bj3200585 | pmid = 8973570 | pmc = 1217969 }} * {{cite journal | vauthors = Kordowska J, Stafford WF, Wang CL | title = Ca2+ and Zn2+ bind to different sites and induce different conformational changes in human calcyclin | journal = Eur. J. Biochem. | volume = 253 | issue = 1 | pages = 57–66 | year = 1998 | pmid = 9578461 | doi = 10.1046/j.1432-1327.1998.2530057.x }} * {{cite journal | vauthors = Yang Q, O'Hanlon D, Heizmann CW, Marks A | title = Demonstration of heterodimer formation between S100B and S100A6 in the yeast two-hybrid system and human melanoma | journal = Exp. Cell Res. | volume = 246 | issue = 2 | pages = 501–9 | year = 1999 | pmid = 9925766 | doi = 10.1006/excr.1998.4314 }} * {{cite journal | vauthors = Sudo T, Hidaka H | title = Characterization of the calcyclin (S100A6) binding site of annexin XI-A by site-directed mutagenesis | journal = FEBS Lett. | volume = 444 | issue = 1 | pages = 11–4 | year = 1999 | pmid = 10037139 | doi = 10.1016/S0014-5793(99)00014-9 | doi-access = free }} * {{cite journal | vauthors = Deloulme JC, Assard N, Mbele GO, Mangin C, Kuwano R, Baudier J | title = S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo | journal = J. Biol. Chem. | volume = 275 | issue = 45 | pages = 35302–10 | year = 2000 | pmid = 10913138 | doi = 10.1074/jbc.M003943200 | doi-access = free }} * {{cite journal | vauthors = Li Y, Yang L, Cui JT, Li WM, Guo RF, Lu YY | title = Construction of cDNA representational difference analysis based on two cDNA libraries and identification of garlic inducible expression genes in human gastric cancer cells | journal = World J. Gastroenterol. | volume = 8 | issue = 2 | pages = 208–12 | year = 2002 | doi = 10.3748/wjg.v8.i2.208 | pmid = 11925593 | pmc = 4658352 | doi-access = free }} * {{cite journal | vauthors = Otterbein LR, Kordowska J, Witte-Hoffmann C, Wang CL, Dominguez R | title = Crystal structures of S100A6 in the Ca(2+)-free and Ca(2+)-bound states: the calcium sensor mechanism of S100 proteins revealed at atomic resolution | journal = Structure | volume = 10 | issue = 4 | pages = 557–67 | year = 2002 | pmid = 11937060 | doi = 10.1016/S0969-2126(02)00740-2 | doi-access = free }} * {{cite journal | vauthors = Filipek A, Jastrzebska B, Nowotny M, Kuznicki J | title = CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family | journal = J. Biol. Chem. | volume = 277 | issue = 32 | pages = 28848–52 | year = 2002 | pmid = 12042313 | doi = 10.1074/jbc.M203602200 | doi-access = free }} {{refend}}

Category:S100 proteins