{{Short description|Protein-coding gene in the species Homo sapiens}} {{cs1 config|name-list-style=vanc}} {{for|the ATRN Extended SMTP command|On-Demand Mail Relay}}
{{Infobox_gene}} '''Attractin''' is a protein that in humans is encoded by the ''ATRN'' gene.<ref name="pmid9736737">{{cite journal | vauthors = Duke-Cohan JS, Gu J, McLaughlin DF, Xu Y, Freeman GJ, Schlossman SF | title = Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 19 | pages = 11336–41 |date=Oct 1998 | pmid = 9736737 | pmc = 21643 | doi =10.1073/pnas.95.19.11336 | bibcode = 1998PNAS...9511336D | doi-access = free }}</ref><ref name="pmid8596018">{{cite journal | vauthors = Duke-Cohan JS, Morimoto C, Rocker JA, Schlossman SF | title = Serum high molecular weight dipeptidyl peptidase IV (CD26) is similar to a novel antigen DPPT-L released from activated T cells | journal = J Immunol | volume = 156 | issue = 5 | pages = 1714–21 |date=Apr 1996 | doi = 10.4049/jimmunol.156.5.1714 | pmid = 8596018 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ATRN attractin| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=8455}}</ref>
Attractin is a Group XI C-type lectin.
Multiple transcript variants encoding different isoforms exist for this gene. One of the isoforms is a membrane-bound protein with sequence similarity to the mouse mahogany protein, a receptor involved in controlling obesity. The other isoform is a secreted protein involved in the initial immune cell clustering during inflammatory responses that may regulate the chemotactic activity of chemokines.<ref name="entrez" />
==References== {{reflist}}
==External links== * {{UCSC gene info|ATRN}}
==Further reading== {{refbegin | 2}} *{{cite journal | vauthors=Mori M, Sakurai M, Araie M |title=[Topical timolol and blood-aqueous barrier permeability to protein in human eyes] |journal=Nippon Ganka Gakkai Zasshi |volume=96 |issue= 11 |pages= 1418–22 |year= 1993 |pmid= 1476071 }} *{{cite journal | author=Nagase T |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro |journal=DNA Res. |volume=5 |issue= 1 |pages= 31–9 |year= 1998 |pmid= 9628581 |doi=10.1093/dnares/5.1.31 | author2=Ishikawa K | author3=Miyajima N | display-authors=3 | last4=Tanaka | first4=A | last5=Kotani | first5=H | last6=Nomura | first6=N | last7=Ohara | first7=O | doi-access=free }} *{{cite journal | author=Nagle DL |title=The mahogany protein is a receptor involved in suppression of obesity |journal=Nature |volume=398 |issue= 6723 |pages= 148–52 |year= 1999 |pmid= 10086355 |doi= 10.1038/18210 | author2=McGrail SH | author3=Vitale J | display-authors=3 | last4=Vitale | first4=James | last5=Woolf | first5=Elizabeth A. | last6=Dussault | first6=Barry J. | last7=Dirocco | first7=Lisa | last8=Holmgren | first8=Lisa | last9=Montagno | first9=Jill |bibcode=1999Natur.398..148N |s2cid=4400267 }} *{{cite journal | author=Gunn TM |title=The mouse mahogany locus encodes a transmembrane form of human attractin |journal=Nature |volume=398 |issue= 6723 |pages= 152–6 |year= 1999 |pmid= 10086356 |doi= 10.1038/18217 | author2=Miller KA | author3=He L | display-authors=3 | last4=He | first4=Lin | last5=Hyman | first5=Richard W. | last6=Davis | first6=Ronald W. | last7=Azarani | first7=Arezou | last8=Schlossman | first8=Stuart F. | last9=Duke-Cohan | first9=Jonathan S. |bibcode=1999Natur.398..152G |s2cid=4371433 }} *{{cite journal | author=Tang W |title=Secreted and membrane attractin result from alternative splicing of the human ATRN gene |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 11 |pages= 6025–30 |year= 2000 |pmid= 10811918 |doi= 10.1073/pnas.110139897 | pmc=18552 | author2=Gunn TM | author3=McLaughlin DF | display-authors=3 | last4=Barsh | first4=GS | last5=Schlossman | first5=SF | last6=Duke-Cohan | first6=JS |bibcode=2000PNAS...97.6025T |doi-access=free }} *{{cite journal | author=Deloukas P |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a | author2=Matthews LH | author3=Ashurst J | display-authors=3 | last4=Burton | first4=J. | last5=Gilbert | first5=J. G. R. | last6=Jones | first6=M. | last7=Stavrides | first7=G. | last8=Almeida | first8=J. P. | last9=Babbage | first9=A. K. |bibcode=2001Natur.414..865D | doi-access=free }} *{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 | author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal | author=Gevaert K |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 | author2=Goethals M | author3=Martens L | display-authors=3 | last4=Van Damme | first4=Jozef | last5=Staes | first5=An | last6=Thomas | first6=Grégoire R. | last7=Vandekerckhove | first7=Joël |s2cid=23783563 }} *{{cite book | vauthors=Friedrich D, Kühn-Wache K, Hoffmann T, Demuth HU |chapter=Isolation and Characterization of Attractin-2 |title=Dipeptidyl Aminopeptidases in Health and Disease |volume=524 |pages= 109–13 |year= 2003 |pmid= 12675230 |doi=10.1007/0-306-47920-6_14 | series=Advances in Experimental Medicine and Biology | isbn=0-306-47717-3 }} *{{cite journal | vauthors=Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wiśniewski JR |title=Screening for N-glycosylated proteins by liquid chromatography mass spectrometry |journal=Proteomics |volume=4 |issue= 2 |pages= 454–65 |year= 2004 |pmid= 14760718 |doi= 10.1002/pmic.200300556 |s2cid=29261009 }} *{{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 | author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }} *{{cite journal | author=Liu T |title=Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 | pmc=1850943 | author2=Qian WJ | author3=Gritsenko MA | display-authors=3 | last4=Camp | first4=David G. | last5=Monroe | first5=Matthew E. | last6=Moore | first6=Ronald J. | last7=Smith | first7=Richard D. }} *{{cite journal | author=Wrenger S |title=Attractin, a dipeptidyl peptidase IV/CD26-like enzyme, is expressed on human peripheral blood monocytes and potentially influences monocyte function |journal=J. Leukoc. Biol. |volume=80 |issue= 3 |pages= 621–9 |year= 2007 |pmid= 16835316 |doi= 10.1189/jlb.1105678 | author2=Faust J | author3=Friedrich D | display-authors=3 | last4=Hoffmann | first4=T | last5=Hartig | first5=R | last6=Lendeckel | first6=U | last7=Kähne | first7=T | last8=Thielitz | first8=A | last9=Neubert | first9=K |s2cid=31858918 | doi-access= }} {{refend}}
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Category:Kelch proteins Category:C-type lectins