{{Infobox medical condition (new) | name = Asterixis | image = | caption = | pronounce = | field = Neurology | synonyms = Flapping tremor, liver flap | symptoms = | complications = | onset = | duration = | types = | causes = | risks = | diagnosis = | differential = | prevention = | treatment = | medication = | prognosis = | frequency = | deaths = }} '''Asterixis''' is a movement disorder that results in jerking of the hands or feet while attempting to hold a position. The resemblance of the hands to flapping wings gives it the colloquial name "flapping tremor" although it is a negative myoclonus rather than a tremor.<ref>{{Cite journal |last1=Agarwal |first1=R. |last2=Baid |first2=R. |date=2016 |title=Asterixis |journal=Journal of Postgraduate Medicine |volume=62 |issue=2 |pages=115–117 |doi=10.4103/0022-3859.180572 |doi-access=free |issn=0972-2823 |pmc=4944342 |pmid=27089111}}</ref><ref>{{Citation|last1=Zackria|first1=Rasiq|title=Asterixis|date=2021|url=https://www.ncbi.nlm.nih.gov/books/NBK535445/|work=StatPearls|place=Treasure Island (FL)|publisher=StatPearls Publishing|pmid=30571066|access-date=2021-03-12|last2=John|first2=Savio|archive-date=2022-06-01|archive-url=https://web.archive.org/web/20220601202545/https://www.ncbi.nlm.nih.gov/books/NBK535445/|url-status=live}}</ref>
The disorder is caused by abnormal function of the diencephalic motor centers in the brain, which regulate the muscles involved in maintaining position. Asterixis is associated with various encephalopathies due especially to faulty metabolism.<ref name="Merriam-Webster.com">{{cite web|title=Asterixis – Definition|url=http://www.merriam-webster.com/medical/asterixis|access-date=2014-11-30|archive-date=2014-12-05|archive-url=https://web.archive.org/web/20141205035947/http://www.merriam-webster.com/medical/asterixis|url-status=live}}</ref> The term derives from the Greek ''a'', meaning "not" and ''stērixis'', meaning "support" or "stable position".
==Presentation== Asterixis is normally asymptomatic and found during clinical examination for other reasons, but more rarely it can also be the leading symptom.<ref name=":0" /> Usually there are brief, arrhythmic interruptions of sustained voluntary muscle contraction, causing brief lapses of posture with a frequency of 3–5Hz. It is typically bilateral, but may be asymmetric. Unilateral asterixis may occur with structural brain disease.<ref>Agarwal R, Baid R. Asterixis. J Postgrad Med 2016;62:115-7. Available from: http://www.jpgmonline.com/text.asp?2016/62/2/115/180572 {{Webarchive|url=https://web.archive.org/web/20180603011047/http://www.jpgmonline.com/text.asp?2016%2F62%2F2%2F115%2F180572 |date=2018-06-03 }}</ref>
To elicit the sign, the patient should be asked to hold constant posture against gravity. This can be done by extending the arms at 90° to the body and extending the wrists with the fingers spread. This position should be held for at least 30 seconds, and in that duration the examiner should look for intermittent loss of posture in the fingers, wrists or arms.<ref name=":0" />
== Associated conditions == Possible causes for asterixis are:<ref name=":0">{{Cite journal |last1=Ellul |first1=Mark A. |last2=Cross |first2=Timothy J. |last3=Larner |first3=Andrew J. |date=2017-02-01 |title=Asterixis |url=https://pn.bmj.com/content/17/1/60 |journal=Practical Neurology |language=en |volume=17 |issue=1 |pages=60–62 |doi=10.1136/practneurol-2016-001393 |issn=1474-7758 |pmid=27807107|s2cid=219191248 |url-access=subscription }}</ref> * Hepatic encephalopathy (for which the term was firstly described). The inability of the liver to metabolize ammonia to urea damages the brain cells. The cause is thought to be predominantly related to abnormal ammonia metabolism.<ref>{{Cite journal |last=Larson |first=Anne M |date=May 2010 |title=Diagnosis and management of acute liver failure: |url=http://journals.lww.com/00001574-201005000-00006 |journal=Current Opinion in Gastroenterology |language=en |volume=26 |issue=3 |pages=214–221 |doi=10.1097/MOG.0b013e32833847c5 |issn=0267-1379|url-access=subscription }}</ref> * Other metabolic encephalopathies (often in conjunction with drowsiness or stupor), especially in decompensated cirrhosis or acute liver failure. * Kidney failure and azotemia. * Wilson's disease. * Respiratory failure due to carbon dioxide toxicity (hypercapnia) or low oxygen (hypoxemia) * Electrolyte imbalances, such as hypokalaemia and hypomagnesaemia. * Encephalopathies, such as Creutzfeldt-Jakob disease<ref>{{Cite journal |last1=Foundas |first1=Maria |last2=Donaldson |first2=Mark D. |last3=McAllister |first3=Ian L. |last4=Bridges |first4=Leslie R. |date=March 2008 |title=Vision loss due to coincident ocular and central causes in a patient with Heidenhain variant Creutzfeldt-Jakob disease |journal=Age and Ageing |volume=37 |issue=2 |pages=231–232 |doi=10.1093/ageing/afm191 |issn=1468-2834 |pmid=18065777}}</ref> * Structural brain problems, like haemorrhage and neoplasia, which usually cause contraleteral one-sided asterixis. * Some drugs, particularly phenytoin (when it is known as phenytoin flap). Other drugs implicated include benzodiazepines, salicylates, barbiturates, valproate, gabapentin, lithium, ceftazidime, and metoclopramide.
==History== R. D. Adams and J. M. Foley first described asterixis in 1949 in patients with severe liver failure and encephalopathy.<ref>Adams RD, Foley JM. The neurological changes in the more common types of severe liver disease. Trans American Neurology Association 1949; 74: 217–219.</ref> Initially Foley and Adams referred to asterixis simply as "tremor" but realized that they needed a more appropriate term. On a literature search they found a poorly described phenomenon in similar patients mentioned by German physicians called “jactitations” but the reference was vague. Foley consulted Father Cadigan, a Jesuit classics scholar, who suggested “anisosterixis” (an "negative"–iso "equal"–sterixis "firmness") but Foley shortened this to asterixis due to the former being too difficult to pronounce. They introduced the term in 1953 by way of a medical abstract and later Adams solidified its medical use as he was an author and editor of the widely influential ''Harrison's Principles of Internal Medicine''.<ref>{{Cite journal |last=Pal |first=Gian |last2=Lin |first2=Mark M. |last3=Laureno |first3=Robert |date=September 2014 |title=Asterixis: a study of 103 patients |url=http://link.springer.com/10.1007/s11011-014-9514-7 |journal=Metabolic Brain Disease |language=en |volume=29 |issue=3 |pages=813–824 |doi=10.1007/s11011-014-9514-7 |issn=0885-7490|url-access=subscription }}</ref>
==References== {{reflist}}
== External links == {{Medical resources | DiseasesDB = 33950 | ICD10 = {{ICD10|R|27|8|r|25}} | ICD9 = {{ICD9|781.3}} | ICDO = | OMIM = | MedlinePlus = | eMedicineSubj = | eMedicineTopic = | MeshID = D020820 }} * [https://web.archive.org/web/20070306023331/http://escuela.med.puc.cl/paginas/publicaciones/Guias/DHC/imagenes/paginas_f/dhc_f40.html Diagram]
{{Nervous and musculoskeletal system symptoms and signs}}
Category:Symptoms and signs: Nervous system