Zinc finger FYVE domain-containing protein 9

{{Short description|Protein found in humans}} {{Infobox_gene}}

'''Zinc finger FYVE domain-containing protein 9''' or '''SARA''' (<u>S</u>MAD <u>a</u>nchor for <u>r</u>eceptor <u>a</u>ctivation) is a protein that in humans is encoded by the '''''ZFYVE9''''' gene.<ref name="pmid9865696">{{cite journal | vauthors = Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL | title = SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor | journal = Cell | volume = 95 | issue = 6 | pages = 779–791 |date=December 1998 | pmid = 9865696 | doi =10.1016/S0092-8674(00)81701-8 | s2cid = 6194655 | doi-access = free }}</ref> SARA contains a double zinc finger (FYVE domain).

SARA is an anchoring protein involved in TGF beta signaling. It binds to the MH2 domain of the R-SMADs SMAD2 and SMAD3 as well as the type I TGF beta receptors.<ref name="pmid15356634">{{cite journal | vauthors = Lin HK, Bergmann S, Pandolfi PP | title = Cytoplasmic PML function in TGF-beta signalling | journal = Nature | volume = 431 | issue = 7005 | pages = 205–211 |date=September 2004 | pmid = 15356634 | doi = 10.1038/nature02783 | bibcode = 2004Natur.431..205L | s2cid = 4301789 }}</ref> It facilitates the phosphorylation of the R-SMAD, which subsequently dissociates from SARA and the receptor and binds a coSMAD where they enter the nucleus as transcription factors.

==References== {{reflist}}

== External links == * [https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/O95405 PDBe-KB] provides an overview of all the structure information available in the PDB for Human Zinc finger FYVE domain-containing protein 9

{{TGF beta signaling}}

Category:Developmental genes and proteins Category:FYVE domain

{{gene-1-stub}}