ZFYVE27

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Zinc finger, FYVE domain containing 27''' is a protein that in humans is encoded by the ZFYVE27 gene.<ref name="entrez">{{cite web | title = Entrez Gene: Zinc finger, FYVE domain containing 27 | url = https://www.ncbi.nlm.nih.gov/gene/118813 }}</ref>

== Function ==

This gene encodes a protein with several Transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote Neurite formation. A mutation in this gene has been reported to be associated with Hereditary spastic paraplegia, however the Pathogenicity of the mutation, which may simply represent a Polymorphism (biology), is unclear. [provided by RefSeq, Mar 2010].

== References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Zhang C, Li D, Ma Y, Yan J, Yang B, Li P, Yu A, Lu C, Ma X | title = Role of spastin and protrudin in neurite outgrowth | journal = Journal of Cellular Biochemistry | volume = 113 | issue = 7 | pages = 2296–307 | date = July 2012 | pmid = 22573551 | doi = 10.1002/jcb.24100 | s2cid = 25893328 }} * {{cite journal | vauthors = Saita S, Shirane M, Natume T, Iemura S, Nakayama KI | title = Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein | journal = The Journal of Biological Chemistry | volume = 284 | issue = 20 | pages = 13766–77 | date = May 2009 | pmid = 19289470 | pmc = 2679478 | doi = 10.1074/jbc.M807938200 | doi-access = free }} * {{cite journal | vauthors = Mannan AU, Krawen P, Sauter SM, Boehm J, Chronowska A, Paulus W, Neesen J, Engel W | title = ZFYVE27 (SPG33), a novel spastin-binding protein, is mutated in hereditary spastic paraplegia | journal = American Journal of Human Genetics | volume = 79 | issue = 2 | pages = 351–7 | date = August 2006 | pmid = 16826525 | pmc = 1559503 | doi = 10.1086/504927 }} * {{cite journal | vauthors = Martignoni M, Riano E, Rugarli EI | title = The role of ZFYVE27/protrudin in hereditary spastic paraplegia | journal = American Journal of Human Genetics | volume = 83 | issue = 1 | pages = 127–8; author reply 128–30 | date = July 2008 | pmid = 18606302 | pmc = 2443834 | doi = 10.1016/j.ajhg.2008.05.014 }} * {{cite journal | vauthors = Matsuzaki F, Shirane M, Matsumoto M, Nakayama KI | title = Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation | journal = Molecular Biology of the Cell | volume = 22 | issue = 23 | pages = 4602–20 | date = December 2011 | pmid = 21976701 | pmc = 3226478 | doi = 10.1091/mbc.E11-01-0068 }} * {{cite journal | vauthors = Shirane M, Nakayama KI | title = Protrudin induces neurite formation by directional membrane trafficking | journal = Science | volume = 314 | issue = 5800 | pages = 818–21 | date = November 2006 | pmid = 17082457 | doi = 10.1126/science.1134027 | bibcode = 2006Sci...314..818S | s2cid = 1728286 }}