ZFYVE16

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Zinc finger FYVE domain-containing protein 16''' is a protein that in humans is encoded by the ''ZFYVE16'' gene.<ref name="pmid11546807">{{cite journal | vauthors = Seet LF, Hong W | title = Endofin, an endosomal FYVE domain protein | journal = The Journal of Biological Chemistry | volume = 276 | issue = 45 | pages = 42445–54 | date = November 2001 | pmid = 11546807 | doi = 10.1074/jbc.M105917200 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ZFYVE16 zinc finger, FYVE domain containing 16| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=9765}}</ref>

The ZFYVE16 gene encodes endofin, an endosomal protein implicated in regulating membrane trafficking. It is characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain positioned in the middle of the molecule.<ref name="pmid14613930" />

In melanocytic cells ZFYVE16 gene expression may be regulated by MITF.<ref name="pmid19067971">{{cite journal | vauthors = Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E | display-authors = 6 | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell & Melanoma Research | volume = 21 | issue = 6 | pages = 665–76 | date = December 2008 | pmid = 19067971 | doi = 10.1111/j.1755-148X.2008.00505.x | s2cid = 24698373 | doi-access = free }}</ref>

== Interactions ==

ZFYVE16 has been shown to interact with TOM1.<ref name=pmid14613930>{{cite journal | vauthors = Seet LF, Liu N, Hanson BJ, Hong W | title = Endofin recruits TOM1 to endosomes | journal = The Journal of Biological Chemistry | volume = 279 | issue = 6 | pages = 4670–9 | date = February 2004 | pmid = 14613930 | doi = 10.1074/jbc.M311228200 | doi-access = free }}</ref>

== References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | display-authors = 6 | title = Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Research | volume = 4 | issue = 2 | pages = 141–50 | date = April 1997 | pmid = 9205841 | doi = 10.1093/dnares/4.2.141 | doi-access = free }} * {{cite journal | vauthors = Seet LF, Liu N, Hanson BJ, Hong W | title = Endofin recruits TOM1 to endosomes | journal = The Journal of Biological Chemistry | volume = 279 | issue = 6 | pages = 4670–9 | date = February 2004 | pmid = 14613930 | doi = 10.1074/jbc.M311228200 | doi-access = free }} * {{cite journal | vauthors = Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC | title = Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry | journal = Analytical Chemistry | volume = 76 | issue = 10 | pages = 2763–72 | date = May 2004 | pmid = 15144186 | doi = 10.1021/ac035352d }} * {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | display-authors = 6 | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Research | volume = 14 | issue = 7 | pages = 1324–32 | date = July 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }} * {{cite journal | vauthors = Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ | display-authors = 6 | title = Immunoaffinity profiling of tyrosine phosphorylation in cancer cells | journal = Nature Biotechnology | volume = 23 | issue = 1 | pages = 94–101 | date = January 2005 | pmid = 15592455 | doi = 10.1038/nbt1046 | s2cid = 7200157 }} * {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | display-authors = 6 | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }} * {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | display-authors = 6 | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = January 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }} * {{cite journal | vauthors = Zhao BM, Hoffmann FM | title = Inhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARA | journal = Molecular Biology of the Cell | volume = 17 | issue = 9 | pages = 3819–31 | date = September 2006 | pmid = 16775010 | pmc = 1556379 | doi = 10.1091/mbc.E05-10-0990 }} * {{cite journal | vauthors = Chen YG, Wang Z, Ma J, Zhang L, Lu Z | title = Endofin, a FYVE domain protein, interacts with Smad4 and facilitates transforming growth factor-beta signaling | journal = The Journal of Biological Chemistry | volume = 282 | issue = 13 | pages = 9688–95 | date = March 2007 | pmid = 17272273 | doi = 10.1074/jbc.M611704200 | doi-access = free }} * {{cite journal | vauthors = Chen Y, Low TY, Choong LY, Ray RS, Tan YL, Toy W, Lin Q, Ang BK, Wong CH, Lim S, Li B, Hew CL, Sze NS, Druker BJ, Lim YP | display-authors = 6 | title = Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells | journal = Proteomics | volume = 7 | issue = 14 | pages = 2384–97 | date = July 2007 | pmid = 17570516 | doi = 10.1002/pmic.200600968 | s2cid = 23944956 }} {{refend}}