{{Infobox scientist | name = Young-Tae Chang | native_name = 장영태 | image = Young-Tae Chang 장영태.jpg | caption = Chang in 2019 | birth_date = {{Birth year and age|1968}} | birth_place = Busan, South Korea | alma_mater = POSTECH (PhD, Chemistry, 1997) | known_for = Diversity-oriented fluorescence library approach (DOFLA); CDy1; CDr3; NeuO; background-free ''tame'' fluorescent probes | awards = Yoshida Prize (2023); Sang-Chul Shim Academic Award (2022); NUS Young Investigator Award (2007); NSF CAREER Award (2005) | fields = Chemistry; bioimaging; fluorescent chemical probes | workplaces = New York University; National University of Singapore; Singapore Bioimaging Consortium; POSTECH; Institute for Basic Science (Center for Self-assembly and Complexity) | doctoral_advisor = Sung-Kee Chung | academic_advisors = Peter G. Schultz | website = http://ytchang.postech.ac.kr | module = {{Infobox Korean name/auto | hangul = %장영태 | child = yes}}}}
'''Young-Tae Chang''' ({{Korean|hangul=장영태}}; born 1968) is a South Korean chemist. He is a professor of chemistry at Pohang University of Science and Technology (POSTECH).
Young-Tae Chang was born in Busan, South Korea in 1968. He obtained the Ph.D. degree in chemistry from POSTECH, working on the divergent synthesis of all regioisomers of ''myo''-inositol phosphates, under guide of Prof. Sung-Kee Chung. Doctoral requirements at POSTECH require a student study at least three years, but Young-Tae finished in two, requiring his advisor to appeal for a revision of the rules which allowed him to receive his doctorate in February 1997.<ref>{{cite web |url= http://weekly.chosun.com/client/news/viw.asp?ctcd=C08&nNewsNumb=002617100021 |title= 암세포에 색깔 입히는 형광물질 연구자 장영태 포항공대 교수 |author= 최준석 |date= 20 July 2020 |website=Weekly Chosun |publisher= |access-date= 27 July 2020 |quote= |language= Korean}}</ref> He then engaged in postdoctoral research in the laboratory of Prof. Peter G. Schultz at University of California, Berkeley and Scripps Research in 2000.
He was appointed assistant professor at New York University (NYU) in 2000 and promoted to associate professor with tenure in 2005. In September 2007, he moved to the National University of Singapore and the [http://www.sbic.a-star.edu.sg/index.php Singapore Bioimaging Consortium] {{Webarchive|url=https://web.archive.org/web/20130602152939/http://www.sbic.a-star.edu.sg/index.php |date=2013-06-02 }} as a lab head at Biopolis. From 2017, he is a Full Professor in the [http://chem.postech.ac.kr/eng/ Department of Chemistry, POSTECH] {{Webarchive|url=https://web.archive.org/web/20170511103356/http://chem.postech.ac.kr/eng/ |date=2017-05-11 }} and the Associate Director under Kim Kimoon at the Center for Self-assembly and Complexity at the Institute for Basic Science located on the POSTECH campus. He pioneered diversity-oriented fluorescence library approach (DOFLA),<ref>{{cite journal|last= VENDREL|first=MARC |author2=Duanting Zhai |author3=Jun Cheng Er |author4=Young-Tae Chang|title=Combinatorial strategies in fluorescent probe development|journal=Chem. Rev.|volume=112|issue=8|pages=4391–4420|doi=10.1021/cr200355j|year=2012|pmid= 22616565}}</ref><ref>{{cite journal|author=Nam-Young Kang|author2=Hyung-Ho Ha|author3=Seong-Wook Yun|author4=Young Hyun Yu|author5=Young-Tae Chang|title=Diversity-driven chemical probe development for biomolecules: beyond hypothesis-driven approach|journal=Chem. Soc. Rev.|volume=40|pages=3613–3626|doi=10.1039/C0CS00172D|year=2011|pmid= 21526237|issue=7}}</ref> and developed embryonic stem cell probe CDy1,<ref>{{cite journal|author=Chang-Nim Im|author2=Nam-Young Kang|author3=Hyung-Ho Ha|author4=Xuezhi Bi|author5=Jae Jung Lee|author6=Sung-Jin Park|author7=Sang Yeon Lee|author8=Marc Vendrell|author9=Yun Kyung Kim|author10=Jun-Seok Lee|author11=Jun Li|author12=Young-Hoon Ahn|author13=Bo Feng|author14=Huck-Hui Ng|author15=Seong-Wook Yun|author16=Young-Tae Chang|title=A Fluorescent Rosamine Compound Selectively Stains Pluripotent Stem Cells|journal=Angew. Chem. Int. Ed.|volume=49|issue=41|pages=7497–7500|doi=10.1002/anie.201002463|year=2010|pmid=20814992|doi-access=free}}</ref> neuronal stem cell probe CDr3,<ref>{{cite journal|author=Seong-Wook Yun|author2=Cheryl Leong|author3=Duanting Zhai|author4=Yee Ling Tan|author5=Linda Limd|author6=Xuezhi Bi|author7=Jae-Jung Lee|author8=Han Jo Kim|author9=Nam-Young Kang|author10=Shin Hui Ng|author11=Lawrence W. Stanton|author12=Young-Tae Chang|title=Neural stem cell specific fluorescent chemical probe binding to FABP7|journal=PNAS|volume=109|issue=26|pages=10214–10217|doi=10.1073/pnas.1200817109|year=2012|pmid= 22689954|pmc=3387064|bibcode=2012PNAS..10910214Y|doi-access=free}}</ref> and neron specific probe, NeuO.<ref>{{Cite journal|last1=Er|first1=Jun Cheng|last2=Leong|first2=Cheryl|last3=Teoh|first3=Chai Lean|last4=Yuan|first4=Qiang|last5=Merchant|first5=Paolomi|last6=Dunn|first6=Matthew|last7=Sulzer|first7=David|last8=Sames|first8=Dalibor|last9=Bhinge|first9=Akshay|date=2015-02-16|title=NeuO: a fluorescent chemical probe for live neuron labeling|journal=Angewandte Chemie International Edition in English|volume=54|issue=8|pages=2442–2446|doi=10.1002/anie.201408614|issn=1521-3773|pmid=25565332}}</ref> He also developed a method for background-free live cell imaging with tamed fluorescent probe.<ref>{{Cite journal|last1=Alamudi|first1=Samira Husen|last2=Satapathy|first2=Rudrakanta|last3=Kim|first3=Jihyo|last4=Su|first4=Dongdong|last5=Ren|first5=Haiyan|last6=Das|first6=Rajkumar|last7=Hu|first7=Lingna|last8=Alvarado-Martínez|first8=Enrique|last9=Lee|first9=Jung Yeol|date=2016-01-01|title=Development of background-free tame fluorescent probes for intracellular live cell imaging|journal=Nature Communications|volume=7|article-number=11964|doi=10.1038/ncomms11964|issn=2041-1723|pmid=27321135|pmc=4915154|bibcode=2016NatCo...711964A}}</ref> He also co-developed a super-photostable small-molecule fluorophore, Phoenix Fluor 555 (PF555), which enables long-term live-cell single-protein imaging.<ref>{{cite journal |author=Do-Hyeon Kim |author2=Hong Minh Triet |author3=Sun Hyeok Lee |author4=Sina Jazani |author5=Seongjae Jang |author6=Syed Ali Abbas Abedi |author7=Xiaogang Liu |author8=Jongcheol Seo |author9=Taekjip Ha |author10=Young-Tae Chang |author11=Sung Ho Ryu |title=Super-photostable organic dye for long-term live-cell single-protein imaging |journal=Nature Methods |volume=22 |issue=3 |pages=550–558 |date=2025-01-15 |doi=10.1038/s41592-024-02584-0 |pmid=39815105 |url=https://www.nature.com/articles/s41592-024-02584-0|url-access=subscription }} </ref> These days, he is focusing on developing fluorescent probes for the selective detection of senescent cells.
He is an editorial board member of ''MedChemComm'' and ''RSC Advances'', Royal Society of Chemistry, Angewandte Chemie and ''[http://ajnmmi.us/ American Journal of Nuclear Medicine and Molecular Imaging]''. He has published more than 400 scientific papers and 3 books resulting in more than 31,000 citations.<ref>{{cite web |url= https://scholar.google.com/citations?user=q6s4ZzAAAAAJ |title= Young-Tae Chang - Google Scholar Citations |author=<!--Not stated--> |date= 22 January 2019 |website= Google Scholar |access-date= 22 April 2022 |quote=}}</ref> Additionally, he has filed more than 60 patents.
== Honors and awards == * 2023: Yoshida Prize, International Organic Chemistry Foundation<ref>{{cite web |url= https://iocf.sbchem.kyoto-u.ac.jp/en/report-yoshida-prize/6th-yoshida-prize-symposium/ |title= 6th Yoshida Prize Symposium |author= <!--Not stated--> |date= |website= International Organic Chemistry Foundation |publisher= |access-date= 9 February 2023 |quote= |language= }}</ref><ref>{{cite web |url= https://iocf.sbchem.kyoto-u.ac.jp/en/yoshida-prize/ |title= Yoshida Prize |author= <!--Not stated--> |date= |website= International Organic Chemistry Foundation |publisher= |access-date= 9 February 2023 |quote= |language= }}</ref> * 2022: Sang-Chul Shim Academic Award<!--심상철 학술상-->, Korean Chemical Society<ref>{{cite web |url= https://www.fnnews.com/news/202204211322016944 |title= POSTECH 장영태 교수, 대한화학회 학술상 수상 |author=김만기 |date= 21 April 2022 |website=The Financial News|publisher= |access-date= 22 April 2022 |quote= |language= Korean}}</ref><ref>{{cite web |url= http://www.kbmaeil.com/news/articleView.html?idxno=927330 |title= 포스텍 장영태 교수, '심상철 학술상' 수상 |author=이시라 |date= 21 April 2022 |website= 경북매일|publisher= |access-date= 22 April 2022 |quote= |language= Korean}}</ref> * 2007: NUS Young Investigator Award * 2005: Career Award, National Science Foundation
==References== {{Reflist}}
==Press coverage== #[https://www.news1.kr/local/daegu-gyeongbuk/5890703 포스텍-한국뇌연구원, 뇌 신경세포 선택적 염색 메커니즘 규명]. ''news1'' (in Korean). Retrieved 26 August 2025. #[https://m.etnews.com/20250417000018?obj=Tzo4OiJzdGRDbGFzcyI6Mjp7czo3OiJyZWZlcmVyIjtOO3M6NzoiZm9yd2FyZCI7czoxMzoid2ViIHRvIG1vYmlsZSI7fQ%3D%3D 포스텍, 색으로 간암 경계를 정확히 구분하는 기술 개발]. ''etnews'' (in Korean). Retrieved 17 April 2025. #[https://www.joongangenews.com/news/articleView.html?idxno=410116 POSTECH 연구팀, 세포 내 단백질의 비밀 밝히는 초광안정적인 유기형광분자 개발]. ''중앙이코노미뉴스'' (in Korean). Retrieved 25 February 2025. #[http://m.fpost.co.kr/board/bbs/board.php?bo_table=newsinnews&wr_id=5822&page=133 한국도레이과학진흥재단 과학기술상에 장영태∙문주호 교수]. ''Fashion post'' (in Korean). Retrieved 5 September 2023. #[https://www.monthlypeople.com/news/articleView.html?idxno=509490 특정 타깃을 구별해주는 형광물질 활용해 ‘암’을 넘어 ‘노화’의 원인과 조절인자 발굴에 도전한다]. ''월간인물'' (in Korean). Retrieved 19 April 2023. #[https://www.news1.kr/local/daegu-gyeongbuk/4994477 암 치료 진단·치료 동시에 가능…포스텍 연구팀 실험으로 입증]. ''News1'' (in Korean). Retrieved 27 March 2023. #[http://www.mediagb.kr/news/view.php?idx=32541 포스텍 장영태 교수팀, 암 진행 돕는 대식세포만 선택 염색하는 형광 프로브 개발]. ''미디어 경북'' (in Korean). Retrieved 20 March 2023. #[https://www.yna.co.kr/view/AKR20230208111600053 포항공대 장영태 교수, 국제유기화학재단 요시다상 받아]. ''연합뉴스'' (in Korean). Retrieved 8 February 2023. #[https://www.etnews.com/20220901000044 세포 소기관별 온도를 영상으로 볼수 있는 형광 온도계 개발]. ''etnews'' (in Korean). Retrieved 1 September 2022. #[https://www.kbmaeil.com/927330 포스텍 장영태 교수, ‘심상철 학술상’ 수상]. ''경북매일'' (in Korean). Retrieved 22 April 2022. #[https://www.fnnews.com/news/202204211322016944 POSTECH 장영태 교수, 대한화학회 학술상 수상]. ''The Financial News'' (in Korean). Retrieved 22 April 2022. #[https://www.hellodd.com/news/articleView.html?idxno=96167 POSTECH, 세포 '형광펜 긋듯' 식별···정확도 높여]. ''helloDD'' (in Korean). Retrieved 8 March 2022. #[https://weekly.chosun.com/news/articleView.html?idxno=16001 암세포에 색깔 입히는 형광물질 연구자 장영태 포항공대 교수]. ''주간조선'' (in Korean). Retrieved 24 July 2020.
== External links == * [http://ytchang.postech.ac.kr/ Professor CHANG Young-Tae, POSTECH] * [https://csc.ibs.re.kr/html/csc_en/people/people_0209.html Associate Director - Center for Self-assembly and Complexity] * [https://scholar.google.com/citations?user=q6s4ZzAAAAAJ Young-Tae Chang - Google Scholar]
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{{DEFAULTSORT:Chang, Young-Tae}} Category:Living people Category:1968 births Category:Institute for Basic Science Category:Academic staff of the National University of Singapore Category:South Korean organic chemists Category:Pohang University of Science and Technology alumni Category:Academic staff of Pohang University of Science and Technology