The '''Working Formulation''' is a classification of non-Hodgkin lymphomas, first proposed in 1982.<ref name=MacKenzie-1985>{{cite journal |vauthors=MacKenzie RG, Rusthoven JJ |title=Management of localized non-Hodgkin's lymphoma |journal=CMAJ |volume=133 |issue=6 |pages=559–64 |date=1985 |pmid=3896450 |pmc=1346220 }}</ref> It has become outdated in light of modern shifts in the understanding and classification of non-Hodgkin lymphomas, leading to the rise of new systems such as the Revised American European Lymphoma classification.<ref>{{Cite web |date=2023-12-15 |title=Non-Hodgkin Lymphoma Treatment (PDQ®) - NCI |url=https://www.cancer.gov/types/lymphoma/hp/adult-nhl-treatment-pdq |access-date=2024-01-22 |website=www.cancer.gov |language=en}}</ref> The Working Formulation is still in use, although it is usually applied when analyzing historical data.<ref>{{Cite web|date=2023-07-24 |title=Non-Hodgkin Lymphoma Guidelines: Classification, Diagnosis, Staging |url=https://emedicine.medscape.com/article/2500022-overview}}</ref>
'''Low Grade''' *Malignant lymphoma, small lymphocytic (chronic lymphocytic leukemia) *Malignant lymphoma, follicular, predominantly small cleaved cell *Malignant lymphoma, follicular, mixed (small cleaved and large cell)
'''Intermediate grade''' *Malignant lymphoma, follicular, predominantly large cell *Malignant lymphoma, diffuse, small cleaved cell *Malignant lymphoma, diffuse, mixed small and large cell *Malignant lymphoma, diffuse, large cell
'''High grade''' *Malignant lymphoma, large cell, immunoblastic *Malignant lymphoma, lymphoblastic *Malignant lymphoma, small noncleaved cells (Burkitt lymphoma)
'''Miscellaneous''' *Composite *Mycosis fungoides *Histiocytic *Extramedullary plasmacytoma *Unclassifiable
== References == {{reflist}}
{{Lymphoid malignancy}}
Category:Lymphoma