WNT5B

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Protein Wnt-5b''' is a [[protein]] that in humans is encoded by the ''WNT5B'' [[gene]].<ref name="pmid11445850">{{cite journal | vauthors = Saitoh T, Katoh M | title = Molecular cloning and characterization of human WNT5B on chromosome 12p13.3 region | journal = Int J Oncol | volume = 19 | issue = 2 | pages = 347–51 |date=Jul 2001 | pmid = 11445850 | doi = 10.3892/ijo.19.2.347}}</ref><ref name="entrez"/>

The [[Wnt signaling pathway|WNT]] gene family consists of structurally-related genes that encode secreted [[Cell signaling|signaling]] proteins. These proteins have been implicated in [[oncogenesis]] and in several developmental processes, including regulation of cell fate and patterning during [[embryogenesis]]. This gene is a member of the WNT gene family. It encodes a protein showing 94% and 80% [[amino acid]] identity to the [[mouse]] Wnt5b protein and the human [[WNT5A]] protein, respectively. Alternative [[Protein splicing|splicing]] of this gene generates two [[transcript variant]]s.<ref name="entrez">{{cite web | title = Entrez Gene: WNT5B wingless-type MMTV integration site family, member 5B| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=81029}}</ref>

==References== {{reflist}}

==Further reading== {{refbegin | 2}} *{{cite journal | vauthors=Smolich BD, McMahon JA, McMahon AP, Papkoff J |title=Wnt family proteins are secreted and associated with the cell surface |journal=Mol. Biol. Cell |volume=4 |issue= 12 |pages= 1267–75 |year= 1994 |pmid= 8167409 |doi= 10.1091/mbc.4.12.1267| pmc=275763 }} *{{cite journal |vauthors=Tanaka K, Okabayashi K, Asashima M, etal |title=The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family |journal=Eur. J. Biochem. |volume=267 |issue= 13 |pages= 4300–11 |year= 2000 |pmid= 10866835 |doi=10.1046/j.1432-1033.2000.01478.x }} *{{cite journal | vauthors=Saitoh T, Katoh M |title=Expression and regulation of WNT5A and WNT5B in human cancer: up-regulation of WNT5A by TNFalpha in MKN45 cells and up-regulation of WNT5B by beta-estradiol in MCF-7 cells |journal=Int. J. Mol. Med. |volume=10 |issue= 3 |pages= 345–9 |year= 2003 |pmid= 12165812 |doi= 10.3892/ijmm.10.3.345}} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Kanazawa A, Tsukada S, Sekine A, etal |title=Association of the Gene Encoding Wingless-Type Mammary Tumor Virus Integration-Site Family Member 5B (WNT5B) with Type 2 Diabetes |journal=Am. J. Hum. Genet. |volume=75 |issue= 5 |pages= 832–43 |year= 2005 |pmid= 15386214 |doi= 10.1086/425340 | pmc=1182112 }} *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} *{{cite journal |vauthors=Mangioni S, Viganò P, Lattuada D, etal |title=Overexpression of the Wnt5b gene in leiomyoma cells: implications for a role of the Wnt signaling pathway in the uterine benign tumor |journal=J. Clin. Endocrinol. Metab. |volume=90 |issue= 9 |pages= 5349–55 |year= 2005 |pmid= 15972578 |doi= 10.1210/jc.2005-0272 |doi-access= free }} *{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }} {{refend}}