WIF1 — Mediated Wiki

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Wnt inhibitory factor 1''' is a protein that in humans is encoded by the ''WIF1'' gene.<ref name="entrez">{{cite web | title = Entrez Gene: WIF1 WNT inhibitory factor 1 | url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=11197}}</ref> WIF1 is a lipid-binding protein that binds to Wnt proteins and prevents them from triggering signalling.<ref name="pmid21743455">{{cite journal | vauthors = Malinauskas T, Aricescu AR, Lu W, Siebold C, Jones EY | title = Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1 | journal = Nature Structural & Molecular Biology | volume = 18 | issue = 8 | pages = 886–893 |date=July 2011 | pmid = 21743455 | pmc=3430870 | doi = 10.1038/nsmb.2081 }}</ref><ref name="pmid=18256869">{{cite journal | author=Malinauskas T |title=Docking of fatty acids into the WIF domain of the human Wnt inhibitory factor-1 |journal=Lipids |volume=43 |issue= 3 |pages=227–30 |year= 2008 |pmid=18256869 |doi=10.1007/s11745-007-3144-3 |s2cid=31357937 }}</ref><ref name="pmid10201374">{{cite journal | vauthors = Hsieh JC, Kodjabachian L, Rebbert ML, Rattner A, Smallwood PM, Samos CH, Nusse R, Dawid IB, Nathans J | title = A new secreted protein that binds to Wnt proteins and inhibits their activities | journal = Nature | volume = 398 | issue = 6726 | pages = 431–6 |date=Apr 1999 | pmid = 10201374 | doi = 10.1038/18899 | bibcode = 1999Natur.398..431H | s2cid = 4376660 }}</ref>

== Function ==

WNT proteins are extracellular signaling molecules involved in the control of embryonic development. This gene encodes a secreted protein, which binds WNT proteins and inhibits their activities. This protein contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. It may be involved in mesoderm segmentation. This protein is found to be present in fish, amphibia and mammals.<ref name="entrez" />

==References== {{reflist}}

==Further reading== {{refbegin | 2}} *{{cite journal | vauthors=Shepelev MV, Korobko EV, Korobko IV |title=[WIF1: perspectives of application in oncology] |journal=Mol. Gen. Mikrobiol. Virusol. |issue= 4 |pages= 3–7 |year= 2006 |pmid= 17094650 }} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }} *{{cite journal |vauthors=Reguart N, He B, Xu Z, etal |title=Cloning and characterization of the promoter of human Wnt inhibitory factor-1. |journal=Biochem. Biophys. Res. Commun. |volume=323 |issue= 1 |pages= 229–34 |year= 2004 |pmid= 15351726 |doi= 10.1016/j.bbrc.2004.08.075 |doi-access= free }} *{{cite journal | vauthors=Esufali S, Bapat B |title=Cross-talk between Rac1 GTPase and dysregulated Wnt signaling pathway leads to cellular redistribution of beta-catenin and TCF/LEF-mediated transcriptional activation. |journal=Oncogene |volume=23 |issue= 50 |pages= 8260–71 |year= 2004 |pmid= 15377999 |doi= 10.1038/sj.onc.1208007 |s2cid=30877665 |doi-access= }} *{{cite journal |vauthors=Ohigashi T, Mizuno R, Nakashima J, etal |title=Inhibition of Wnt signaling downregulates Akt activity and induces chemosensitivity in PTEN-mutated prostate cancer cells. |journal=Prostate |volume=62 |issue= 1 |pages= 61–8 |year= 2005 |pmid= 15389810 |doi= 10.1002/pros.20117 |s2cid=1398615 }} *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} *{{cite journal | vauthors=Simon M, Grandage VL, Linch DC, Khwaja A |title=Constitutive activation of the Wnt/beta-catenin signalling pathway in acute myeloid leukaemia. |journal=Oncogene |volume=24 |issue= 14 |pages= 2410–20 |year= 2005 |pmid= 15735743 |doi= 10.1038/sj.onc.1208431 |doi-access= free }} *{{cite journal |vauthors=Taniguchi H, Yamamoto H, Hirata T, etal |title=Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers. |journal=Oncogene |volume=24 |issue= 53 |pages= 7946–52 |year= 2005 |pmid= 16007117 |doi= 10.1038/sj.onc.1208910 |doi-access= free }} *{{cite journal |vauthors=Lin YC, You L, Xu Z, etal |title=Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines. |journal=Biochem. Biophys. Res. Commun. |volume=341 |issue= 2 |pages= 635–40 |year= 2006 |pmid= 16427602 |doi= 10.1016/j.bbrc.2005.12.220 }} *{{cite journal |vauthors=Urakami S, Shiina H, Enokida H, etal |title=Epigenetic inactivation of Wnt inhibitory factor-1 plays an important role in bladder cancer through aberrant canonical Wnt/beta-catenin signaling pathway. |journal=Clin. Cancer Res. |volume=12 |issue= 2 |pages= 383–91 |year= 2006 |pmid= 16428476 |doi= 10.1158/1078-0432.CCR-05-1344 |s2cid=22202251 |doi-access= }} *{{cite journal | vauthors=Liepinsh E, Bányai L, Patthy L, Otting G |title=NMR structure of the WIF domain of the human Wnt-inhibitory factor-1. |journal=J. Mol. Biol. |volume=357 |issue= 3 |pages= 942–50 |year= 2006 |pmid= 16476441 |doi= 10.1016/j.jmb.2006.01.047 }} *{{cite journal |vauthors=Batra S, Shi Y, Kuchenbecker KM, etal |title=Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma. |journal=Biochem. Biophys. Res. Commun. |volume=342 |issue= 4 |pages= 1228–32 |year= 2006 |pmid= 16516163 |doi= 10.1016/j.bbrc.2006.02.084 }} *{{cite journal | vauthors=Chim CS, Chan WW, Pang A, Kwong YL |title=Preferential methylation of Wnt inhibitory factor-1 in acute promyelocytic leukemia: an independent poor prognostic factor. |journal=Leukemia |volume=20 |issue= 5 |pages= 907–9 |year= 2006 |pmid= 16525492 |doi= 10.1038/sj.leu.2404176 |doi-access= free }} *{{cite journal |vauthors=Urakami S, Shiina H, Enokida H, etal |title=Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection. |journal=Clin. Cancer Res. |volume=12 |issue= 7 Pt 1 |pages= 2109–16 |year= 2006 |pmid= 16609023 |doi= 10.1158/1078-0432.CCR-05-2468 |doi-access= free }} *{{cite journal | vauthors=Milutinovic S, D'Alessio AC, Detich N, Szyf M |title=Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes. |journal=Carcinogenesis |volume=28 |issue= 3 |pages= 560–71 |year= 2007 |pmid= 17012225 |doi= 10.1093/carcin/bgl167 |doi-access= free }} *{{cite journal | vauthors=Queimado L, Lopes CS, Reis AM |title=WIF1, an inhibitor of the Wnt pathway, is rearranged in salivary gland tumors. |journal=Genes Chromosomes Cancer |volume=46 |issue= 3 |pages= 215–25 |year= 2007 |pmid= 17171686 |doi= 10.1002/gcc.20402 |s2cid=34184943 }} *{{cite journal |vauthors=Chan SL, Cui Y, van Hasselt A, etal |title=The tumor suppressor Wnt inhibitory factor 1 is frequently methylated in nasopharyngeal and esophageal carcinomas. |journal=Lab. Invest. |volume=87 |issue= 7 |pages= 644–50 |year= 2007 |pmid= 17384664 |doi= 10.1038/labinvest.3700547 |doi-access= free }} *{{cite journal |vauthors=Veeck J, Wild PJ, Fuchs T, etal |title=Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer. |journal=BMC Cancer |volume=9 |pages= 1–13 |year= 2009 |pmid= 19570204 |doi= 10.1186/1471-2407-9-217 | pmc=2717119 |doi-access=free }} {{refend}}