ULK2 — Mediated Wiki

{{infobox protein | Name = unc-51-like kinase 2 (C. elegans) | caption = | image = | width = | HGNCid = 13480 | Symbol = ULK2 | AltSymbols = | EntrezGene = 9706 | OMIM = 608650 | RefSeq = NM_014683 | UniProt = Q8IYT8 | PDB = | ECnumber = 2.7.11.1 | Chromosome = 17 | Arm = p | Band = 11.2 | LocusSupplementaryData = }} '''Unc-51-like kinase 2 (C. elegans)''' also known as '''ULK2''' is an enzyme which in humans is encoded by the ''ULK2'' gene.<ref name="pmid10557072">{{cite journal | vauthors = Yan J, Kuroyanagi H, Tomemori T, Okazaki N, Asato K, Matsuda Y, Suzuki Y, Ohshima Y, Mitani S, Masuho Y, Shirasawa T, Muramatsu M | title = Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains | journal = Oncogene | volume = 18 | issue = 43 | pages = 5850–9 |date=October 1999 | pmid = 10557072 | doi = 10.1038/sj.onc.1202988 | doi-access = free }}</ref> The gene is located within the Smith–Magenis syndrome region on chromosome 17.

== Structure and function ==

This gene encodes a protein that is similar to a serine/threonine kinase in ''C. elegans'' which is involved in axonal elongation. The structure of this protein is similar to the ''C. elegans'' protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain.<ref name="entrez">{{cite web | title = Entrez Gene: ULK2 | url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=9706}}</ref> ULK2 and the GTPase activating protein SynGAP function cooperatively in axon formation.<ref name="pmid15014045">{{cite journal | vauthors = Tomoda T, Kim JH, Zhan C, Hatten ME | title = Role of Unc51.1 and its binding partners in CNS axon outgrowth | journal = Genes Dev. | volume = 18 | issue = 5 | pages = 541–58 |date=March 2004 | pmid = 15014045 | pmc = 374236 | doi = 10.1101/gad.1151204 }}</ref>

== References == {{Reflist}}

==External links== * {{MeSH name|ULK2+protein,+mouse}}