UCHL3

{{Short description|Human gene and enzyme}} {{Infobox_gene}} '''Ubiquitin carboxyl-terminal hydrolase isozyme L3''' is an enzyme that in humans is encoded by the ''UCHL3'' gene.<ref name="pmid2530630">{{cite journal | vauthors = Wilkinson KD, Lee KM, Deshpande S, Duerksen-Hughes P, Boss JM, Pohl J | title = The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase | journal = Science | volume = 246 | issue = 4930 | pages = 670–3 |date=Dec 1989 | pmid = 2530630 | doi =10.1126/science.2530630 | bibcode = 1989Sci...246..670W }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=7347}}</ref>

==Interactions== UCHL3 has been shown to interact with NEDD8 and the tauopathy and synucleinopathy associated mutated ubiquitin molecule UBB+1.<ref name="pmid21762696">{{cite journal | vauthors = Dennissen FJ, Kholod N, Hermes DJ, Kemmerling N, Steinbusch HW, Dantuma NP, van Leeuwen FW | title = Mutant ubiquitin (UBB(+1)) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3) | journal = FEBS Lett | volume = 585| issue = 16| pages = 2568–74|date=July 2011 | pmid = 21762696 | doi = 10.1016/j.febslet.2011.06.037 | s2cid = 28207136 | doi-access = free }}</ref><ref name="pmid9790970">{{cite journal | vauthors = Wada H, Kito K, Caskey LS, Yeh ET, Kamitani T | title = Cleavage of the C-terminus of NEDD8 by UCH-L3 | journal = Biochem. Biophys. Res. Commun. | volume = 251 | issue = 3 | pages = 688–92 |date=October 1998 | pmid = 9790970 | doi = 10.1006/bbrc.1998.9532 }}</ref>

==References== {{reflist}}

==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Johnston SC, Larsen CN, Cook WJ, etal |title=Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution. |journal=EMBO J. |volume=16 |issue= 13 |pages= 3787–96 |year= 1997 |pmid= 9233788 |doi= 10.1093/emboj/16.13.3787 | pmc=1170002 }} *{{cite journal |vauthors=Wilkinson KD, Laleli-Sahin E, Urbauer J, etal |title=The binding site for UCH-L3 on ubiquitin: mutagenesis and NMR studies on the complex between ubiquitin and UCH-L3. |journal=J. Mol. Biol. |volume=291 |issue= 5 |pages= 1067–77 |year= 1999 |pmid= 10518943 |doi=10.1006/jmbi.1999.3038 }} *{{cite journal | vauthors=Baek SH, Yoo YJ, Tanaka K, Chung CH |title=Molecular cloning of chick UCH-6 which shares high similarity with human UCH-L3: its unusual substrate specificity and tissue distribution. |journal=Biochem. Biophys. Res. Commun. |volume=264 |issue= 1 |pages= 235–40 |year= 1999 |pmid= 10527871 |doi= 10.1006/bbrc.1999.1492 }} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Saito S, Iida A, Sekine A, etal |title=Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population. |journal=J. Hum. Genet. |volume=48 |issue= 5 |pages= 249–70 |year= 2003 |pmid= 12721789 |doi= 10.1007/s10038-003-0021-7 |doi-access= free }} *{{cite journal |vauthors=Nam MJ, Madoz-Gurpide J, Wang H, etal |title=Molecular profiling of the immune response in colon cancer using protein microarrays: occurrence of autoantibodies to ubiquitin C-terminal hydrolase L3. |journal=Proteomics |volume=3 |issue= 11 |pages= 2108–15 |year= 2004 |pmid= 14595809 |doi= 10.1002/pmic.200300594 |s2cid=27511690 }} *{{cite journal |vauthors=Dunham A, Matthews LH, Burton J, etal |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 | pmc=2665288 |bibcode=2004Natur.428..522D }} *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} *{{cite journal |vauthors=Misaghi S, Galardy PJ, Meester WJ, etal |title=Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate. |journal=J. Biol. Chem. |volume=280 |issue= 2 |pages= 1512–20 |year= 2005 |pmid= 15531586 |doi= 10.1074/jbc.M410770200 |doi-access= free }} *{{cite journal |vauthors=Rolén U, Kobzeva V, Gasparjan N, etal |title=Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines. |journal=Mol. Carcinog. |volume=45 |issue= 4 |pages= 260–9 |year= 2006 |pmid= 16402389 |doi= 10.1002/mc.20177 |s2cid=6633207 }} *{{cite journal |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |doi-access= free }} {{refend}}

Category:Genes on human chromosome 13