{{Pfam_box | Symbol = OEP | Name = Outer membrane efflux protein | image =1yc9_opm.png | width = 200 | caption = | Pfam= PF02321 | InterPro= IPR003423 | SMART= | Prosite = | SCOP = 1ek9 | TCDB = 1.B.17 | OPM family= 34 | OPM protein= 1yc9 | PDB= }}
The '''outer membrane efflux protein''' is a protein family member that forms trimeric (three-piece) channels allowing the export of a variety of substrates in gram-negative bacteria. Each efflux protein is composed of two repeats. The trimeric channel is composed of a 12-stranded beta-barrel that spans the outer membrane, and a long tail helical barrel that spans the periplasm.
Examples include the ''Escherichia coli'' TolC outer membrane protein, which is required for proper expression of outer membrane protein genes; the Rhizobium nodulation protein; and the Pseudomonas FusA protein, which is involved in resistance to fusaric acid.
== References == * {{cite journal | vauthors = Johnson JM, Church GM | title = Alignment and structure prediction of divergent protein families: periplasmic and outer membrane proteins of bacterial efflux pumps | journal = Journal of Molecular Biology | volume = 287 | issue = 3 | pages = 695–715 | date = April 1999 | pmid = 10092468 | doi = 10.1006/jmbi.1999.2630 | citeseerx = 10.1.1.73.559 }} Category:Protein domains Category:Protein families Category:Outer membrane proteins {{membrane-protein-stub}}