{{cs1 config|name-list-style=vanc}} {{chembox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 444215306 | ImageFile=Temefos.svg | ImageFile2=Temefos 3D.png | ImageSize=300px | ImageSize2=300px | PIN=''O''-[4-({4-[(Dimethoxyphosphorothioyl)oxy]phenyl}sulfanyl)phenyl] ''O'',''O''-dimethyl phosphorothioate | OtherNames=[4-(4-dimethoxyphosphinothioyloxyphenyl)sulfanylphenoxy]-<br />dimethoxy-sulfanylidene-phosphorane |Section1={{Chembox Identifiers | UNII_Ref = {{fdacite|correct|FDA}} | UNII = ONP3ME32DL | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 5199 | InChI = 1/C16H20O6P2S3/c1-17-23(25,18-2)21-13-5-9-15(10-6-13)27-16-11-7-14(8-12-16)22-24(26,19-3)20-4/h5-12H,1-4H3 | InChIKey = WWJZWCUNLNYYAU-UHFFFAOYAC | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C16H20O6P2S3/c1-17-23(25,18-2)21-13-5-9-15(10-6-13)27-16-11-7-14(8-12-16)22-24(26,19-3)20-4/h5-12H,1-4H3 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = WWJZWCUNLNYYAU-UHFFFAOYSA-N | CASNo_Ref = {{cascite|correct|??}} | CASNo=3383-96-8 | PubChem=5392 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 1355821 | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D06062 | ChEBI_Ref = {{ebicite|correct|EBI}} | ChEBI = 38954 | SMILES = S=P(OC)(OC)Oc2ccc(Sc1ccc(OP(=S)(OC)OC)cc1)cc2 | MeSHName=Temefos }} |Section2={{Chembox Properties | C=16 | H=20 | O=6 | P=2 | S=3 | Appearance= white, crystalline solid<ref name=PGCH/> | Density=1.32 g cm<sup>−3</sup> | MeltingPtC=30 | BoilingPtC=120-125<ref name=PGCH/> | BoilingPt_notes = (decomposes) | Solubility= insoluble<ref name=PGCH/> | VaporPressure = 0.00000007 mmHg (20°C)<ref name=PGCH/> }} |Section3={{Chembox Hazards | MainHazards= | FlashPt= | AutoignitionPt = | PEL = 15 mg/m<sup>3</sup><ref name=PGCH>{{PGCH|0589}}</ref> | IDLH = N.D.<ref name=PGCH/> | REL = TWA 10 mg/m<sup>3</sup> (total) TWA 5 mg/m<sup>3</sup> (resp)<ref name=PGCH/> }} }}
'''Temefos''' or '''temephos''' (trade name '''Abate''') is an organophosphate larvicide used to treat water infested with disease-carrying insects<ref>[http://www.basfpublichealth.com/products/abate.html Abate Product Information]</ref> (including mosquitoes, midges, and black fly larvae) and crustaceans (copepods).
As with other organophosphates, temephos affects the central nervous system through inhibition of cholinesterase. In larvae, this results in death before reaching the adult stage.
In the developing world where the vector-borne disease dengue fever is endemic, temephos is widely used and applied by both private and public pest control in areas of standing water where the ''Aedes aegypti'' mosquito breeds, in order to reduce the population of this disease-carrying insect.<ref>[https://nytimes.com/2006/03/26/international/africa/26worm.html?pagewanted=all ''New York Times'' article covering its application in Africa]</ref> Temephos is also used in the Guinea Worm Eradication Program to kill the copepods that carry guinea worm larvae.<ref>{{cite web|url=https://www.cdc.gov/guinea-worm/hcp/clinical-guidance/|title=Clinical Guidance for Guinea Worm|website=U.S. Centers for Disease Control and Prevention|access-date=25 April 2025|date=15 March 2024}}</ref>
Resistance to temephos by ''A. aegypti'' has been seen in Brazil. The Brazilian Aedes aegypti resistance monitoring program detected temephos resistance in ''A. aegypti'' populations from several localities in the country in 1999 (Funasa 2000, Lima et al. 2003). In 1999, mosquitoes from the city of Rio de Janeiro were observed to be resistant to temephos.<ref>{{cite journal |vauthors=Lima JB, Da-Cunha MP, Da Silva RC, etal |title=Resistance of Aedes aegypti to organophosphates in several municipalities in the State of Rio de Janeiro and Espírito Santo, Brazil |journal=Am. J. Trop. Med. Hyg. |volume=68 |issue=3 |pages=329–33 |year=2003 |doi=10.4269/ajtmh.2003.68.329 |pmid=12685640 |url=https://www.arca.fiocruz.br/handle/icict/40641 }}</ref>
==References== {{Reflist}}
==External links== * [https://www.cdc.gov/niosh/npg/npgd0589.html NIOSH Pocket Guide to Chemical Hazards] * [https://www.cdc.gov/niosh/ipcsneng/neng0199.html International Chemical Safety Cards] * [https://agriculture.basf.com/global/en/business-areas/public-health/products/abate Abate] product website by BASF * {{PPDB|618}}
== Bibliography == * Dejous C & Elouard J.M (1977) [http://horizon.documentation.ird.fr/exl-doc/pleins_textes/cahiers/hydrobio/18237.pdf Action de l'abate sur les invertébérs aquatiques ; cinétique de décrochement à court et moyen terme] (in French).
{{Insecticides}} {{Acetylcholine metabolism and transport modulators}} {{Authority control}}
Category:Acetylcholinesterase inhibitors Category:Neurotoxins Category:Organophosphate insecticides Category:Thioethers Category:Organothiophosphate esters