TELO2 interacting protein 2 is a protein that is encoded by the TTI2 gene in humans. [1]

Function

This gene encodes a regulator of the DNA damage response. The protein is a component of the Triple T complex (TTT) which also includes telomere length regulation protein and TELO2 interacting protein 1.

The TTT complex is involved in cellular resistance to DNA damage stresses and may act as a regulator of phosphoinositide-3-kinase-related protein kinase (PIKK) abundance.

References

  1. ^ "Entrez Gene: TELO2 interacting protein 2". Retrieved 2016-12-14.

Further reading

  • Hurov KE, Cotta-Ramusino C, Elledge SJ (2010). "A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability". Genes Dev.. 24 (17): 1939–50. doi:10.1101/gad.1934210. PMC 2932975. PMID 20810650