{{cs1 config|name-list-style=vanc}} {{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Translin-associated protein X''' (abbr. '''TSNAX''' or '''TRAX''') is a protein that in humans is encoded by the ''TSNAX'' gene.<ref name="pmid9013868">{{cite journal | vauthors = Aoki K, Ishida R, Kasai M | title = Isolation and characterization of a cDNA encoding a Translin-like protein, TRAX | journal = FEBS Letters | volume = 401 | issue = 2–3 | pages = 109–12 | date = Jan 1997 | pmid = 9013868 | doi = 10.1016/S0014-5793(96)01444-5 | doi-access = | bibcode = 1997FEBSL.401..109A | s2cid = 46704829 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TSNAX translin-associated factor X| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=7257}}</ref>
== Function ==
This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs.<ref name="entrez" /> Both TSNAX and translin form the C3PO complex which facilitates endonucleolytic cleavage of the passenger strand during microRNA loading into the RNA-induced silencing complex (RISC).<ref>{{cite journal | vauthors = Ha M, Kim VN | title = Regulation of microRNA biogenesis | journal = Nature Reviews Molecular Cell Biology | volume = 15 | issue = 8 | pages = 509–24 | date = Aug 2014 | pmid = 25027649 | doi = 10.1038/nrm3838 | s2cid = 205495632 }}</ref>
== Interactions ==
TSNAX has been shown to interact with C1D.<ref name=pmid11801738>{{cite journal | vauthors = Erdemir T, Bilican B, Oncel D, Goding CR, Yavuzer U | title = DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX) | journal = Journal of Cell Science | volume = 115 | issue = Pt 1 | pages = 207–16 | date = Jan 2002 | doi = 10.1242/jcs.115.1.207 | pmid = 11801738 | hdl = 11693/24740 | hdl-access = free }}</ref>
== References == {{reflist}}
== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Millar JK, Christie S, Semple CA, Porteous DJ | title = Chromosomal location and genomic structure of the human translin-associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISC1, a gene disrupted by a translocation segregating with schizophrenia | journal = Genomics | volume = 67 | issue = 1 | pages = 69–77 | date = Jul 2000 | pmid = 10945471 | doi = 10.1006/geno.2000.6239 }} * {{cite journal | vauthors = Meng G, Aoki K, Tokura K, Nakahara K, Inazawa J, Kasai M | title = Genomic structure and chromosomal localization of the gene encoding TRAX, a Translin-associated factor X | journal = Journal of Human Genetics | volume = 45 | issue = 5 | pages = 305–8 | year = 2000 | pmid = 11043515 | doi = 10.1007/s100380070022 | doi-access = free }} * {{cite journal | vauthors = Chennathukuzhi VM, Kurihara Y, Bray JD, Hecht NB | title = Trax (translin-associated factor X), a primarily cytoplasmic protein, inhibits the binding of TB-RBP (translin) to RNA | journal = The Journal of Biological Chemistry | volume = 276 | issue = 16 | pages = 13256–63 | date = Apr 2001 | pmid = 11278549 | doi = 10.1074/jbc.M009707200 | doi-access = free }} * {{cite journal | vauthors = Erdemir T, Bilican B, Oncel D, Goding CR, Yavuzer U | title = DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX) | journal = Journal of Cell Science | volume = 115 | issue = Pt 1 | pages = 207–16 | date = Jan 2002 | doi = 10.1242/jcs.115.1.207 | pmid = 11801738 | hdl = 11693/24740 | hdl-access = free }} * {{cite journal | vauthors = Bray JD, Chennathukuzhi VM, Hecht NB | title = Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X | journal = Genomics | volume = 79 | issue = 6 | pages = 799–808 | date = Jun 2002 | pmid = 12036294 | doi = 10.1006/geno.2002.6779 }} * {{cite journal | vauthors = Wu RF, Osatomi K, Terada LS, Uyeda K | title = Identification of Translin/Trax complex as a glucose response element binding protein in liver | journal = Biochimica et Biophysica Acta (BBA) - General Subjects | volume = 1624 | issue = 1–3 | pages = 29–35 | date = Dec 2003 | pmid = 14642810 | doi = 10.1016/j.bbagen.2003.09.002 }} * {{cite journal | vauthors = Yang S, Cho YS, Chennathukuzhi VM, Underkoffler LA, Loomes K, Hecht NB | title = Translin-associated factor X is post-transcriptionally regulated by its partner protein TB-RBP, and both are essential for normal cell proliferation | journal = The Journal of Biological Chemistry | volume = 279 | issue = 13 | pages = 12605–14 | date = Mar 2004 | pmid = 14711818 | doi = 10.1074/jbc.M313133200 | doi-access = free }} * {{cite journal | vauthors = Gocke CB, Yu H, Kang J | title = Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates | journal = The Journal of Biological Chemistry | volume = 280 | issue = 6 | pages = 5004–12 | date = Feb 2005 | pmid = 15561718 | doi = 10.1074/jbc.M411718200 | doi-access = free }} * {{cite journal | vauthors = Thomson PA, Wray NR, Millar JK, Evans KL, Hellard SL, Condie A, Muir WJ, Blackwood DH, Porteous DJ | title = Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population | journal = Molecular Psychiatry | volume = 10 | issue = 7 | pages = 657–68, 616 | date = Jul 2005 | pmid = 15838535 | doi = 10.1038/sj.mp.4001669 | doi-access = | s2cid = 144686652 }} * {{cite journal | vauthors = Gupta GD, Makde RD, Kamdar RP, D'Souza JS, Kulkarni MG, Kumar V, Rao BJ | title = Co-expressed recombinant human Translin-Trax complex binds DNA | journal = FEBS Letters | volume = 579 | issue = 14 | pages = 3141–6 | date = Jun 2005 | pmid = 15919079 | doi = 10.1016/j.febslet.2005.05.007 | doi-access = free | bibcode = 2005FEBSL.579.3141G }} * {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R | s2cid = 4427026 }} {{refend}}
== External links == * {{PDBe-KB2|Q99598|Translin-associated protein X}}
Category:Biology of bipolar disorder
{{gene-1-stub}}