Transcriptional-regulating factor 1 is a protein that in humans is encoded by the TRERF1 gene.[1][2]

This gene encodes a zinc-finger transcriptional regulating protein that interacts with CBP/p300 to regulate the human gene CYP11A1.[2]

Interactions

TRERF1 has been shown to interact with Steroidogenic factor 1,[3] EP300[1] and CREB-binding protein.[1]

References

  1. ^ Gizard F, Lavallée B, DeWitte F, Hum DW (September 2001). "A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression". The Journal of Biological Chemistry. 276 (36): 33881–92. doi:10.1074/jbc.M100113200. PMID 11349124
  2. ^ "Entrez Gene: TRERF1 transcriptional regulating factor 1"
  3. ^ Gizard F, Lavallee B, DeWitte F, Teissier E, Staels B, Hum DW (October 2002). "The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells". The Journal of Biological Chemistry. 277 (42): 39144–55. doi:10.1074/jbc.M205786200. PMID 12101186

Further reading

  • Dorssers LC, Veldscholte J (August 1997). "Identification of a novel breast-cancer-anti-estrogen-resistance (BCAR2) locus by cell-fusion-mediated gene transfer in human breast-cancer cells". International Journal of Cancer. 72 (4): 700–5. doi:10.1002/(SICI)1097-0215(19970807)72:4<700::AID-IJC24>3.0.CO;2-D. PMID 9259413. S2CID 29607511
  • Gizard F, Lavallee B, DeWitte F, Teissier E, Staels B, Hum DW (October 2002). "The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells". The Journal of Biological Chemistry. 277 (42): 39144–55. doi:10.1074/jbc.M205786200. PMID 12101186
  • Gizard F, El-Alfy M, Duguay Y, Lavallée B, DeWitte F, Staels B, Beatty BG, Hum DW (November 2002). "Function of the transcriptional regulating protein of 132 kDa (TReP-132) on human P450scc gene expression". Endocrine Research. 28 (4): 559–74. doi:10.1081/ERC-120016841. PMID 12530663. S2CID 22485023
  • Gizard F, Teissier E, Dufort I, Luc G, Luu-The V, Staels B, Hum DW (April 2004). "The transcriptional regulating protein of 132 kDa (TReP-132) differentially influences steroidogenic pathways in human adrenal NCI-H295 cells". Journal of Molecular Endocrinology. 32 (2): 557–69. doi:10.1677/jme.0.0320557. PMID 15072559
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935
  • Gizard F, Robillard R, Barbier O, Quatannens B, Faucompré A, Révillion F, Peyrat JP, Staels B, Hum DW (June 2005). "TReP-132 controls cell proliferation by regulating the expression of the cyclin-dependent kinase inhibitors p21WAF1/Cip1 and p27Kip1". Molecular and Cellular Biology. 25 (11): 4335–48. doi:10.1128/MCB.25.11.4335-4348.2005. PMC 1140623. PMID 15899840
  • Gizard F, Robillard R, Gross B, Barbier O, Révillion F, Peyrat JP, Torpier G, Hum DW, Staels B (October 2006). "TReP-132 is a novel progesterone receptor coactivator required for the inhibition of breast cancer cell growth and enhancement of differentiation by progesterone". Molecular and Cellular Biology. 26 (20): 7632–44. doi:10.1128/MCB.00326-06. PMC 1636875. PMID 17015480