TNS1

Tensin-1 is a protein that in humans is encoded by the TNS1 gene.^[1]

The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. A second transcript from this gene has been described, but its full length nature has not been determined.^[1]

References

1. ^ "Entrez Gene: TNS1 tensin 1"

External links

• TNS1 Archived 2011-07-22 at the Wayback Machine Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine

Further reading

• Jankowski SA, Gumucio DL (1996). "Genes for tensin, villin and desmin are linked on mouse chromosome 1.". Mamm. Genome. 6 (10): 744–5. doi:10.1007/BF00354299. hdl:2027.42/47016. PMID 8563175. S2CID 22316923
• Salgia R, Pisick E, Sattler M, etal (1996). "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene.". J. Biol. Chem.. 271 (41): 25198–203. doi:10.1074/jbc.271.41.25198. PMID 8810278
• Dias Neto E, Correa RG, Verjovski-Almeida S, etal (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A.. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800
• Katz BZ, Zohar M, Teramoto H, etal (2000). "Tensin can induce JNK and p38 activation.". Biochem. Biophys. Res. Commun.. 272 (3): 717–20. doi:10.1006/bbrc.2000.2853. PMID 10860821
• Chen H, Ishii A, Wong WK, etal (2001). "Molecular characterization of human tensin.". Biochem. J.. 351 Pt 2 (2): 403–11. doi:10.1042/0264-6021:3510403. PMC 1221376. PMID 11023826
• Benzing T, Gerke P, Höpker K, etal (2001). "Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2.". Proc. Natl. Acad. Sci. U.S.A.. 98 (17): 9784–9. Bibcode:2001PNAS...98.9784B. doi:10.1073/pnas.171269898. PMC 55530. PMID 11493697
• Strausberg RL, Feingold EA, Grouse LH, etal (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A.. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932
• Ota T, Suzuki Y, Nishikawa T, etal (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet.. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039
• Yamashita M, Horikoshi S, Asanuma K, etal (2004). "Tensin is potentially involved in extracellular matrix production in mesangial cells.". Histochem. Cell Biol.. 121 (3): 245–54. doi:10.1007/s00418-004-0626-8. PMID 14991332. S2CID 5634607
• Olsen JV, Blagoev B, Gnad F, etal (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573
• Eto M, Kirkbride J, Elliott E, etal (2007). "Association of the tensin N-terminal protein-tyrosine phosphatase domain with the alpha isoform of protein phosphatase-1 in focal adhesions.". J. Biol. Chem.. 282 (24): 17806–15. doi:10.1074/jbc.M700944200. PMID 17435217