'''TLI''' may refer to:
* Thallium(I) iodide, a Thallium compound * Transport Layer Interface, a networking application programming interface. * Trans-lunar injection, a propulsive maneuver used to set a spacecraft on a trajectory which will arrive at the Moon. * Tseng Laboratories, Inc., the full corporate name of Tseng Labs * Tall Latte index, an economic index based on the cost of a cup of Starbucks coffee * Taipei Language Institute, an institute for teaching Mandarin Chinese founded in 1956 * The Lonely Island, an American comedy troupe *The Living Infinite * Trophic level index, an index used in New Zealand for measuring the nutrient content of a lake * Term Life Insurance * Temporal light interference, undesired degradation or malfunction of an equipment or system caused by light modulations
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