TIMM13

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Mitochondrial import inner membrane translocase subunit Tim13''' is an enzyme that in humans is encoded by the ''TIMM13'' gene.<ref name="pmid10552927">{{cite journal | vauthors = Jin H, Kendall E, Freeman TC, Roberts RG, Vetrie DL | title = The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins | journal = Genomics | volume = 61 | issue = 3 | pages = 259–67 | date = Nov 1999 | pmid = 10552927 | doi = 10.1006/geno.1999.5966 }}</ref><ref name="pmid17329230">{{cite journal | vauthors = Gentle IE, Perry AJ, Alcock FH, Likić VA, Dolezal P, Ng ET, Purcell AW, McConnville M, Naderer T, Chanez AL, Charrière F, Aschinger C, Schneider A, Tokatlidis K, Lithgow T | title = Conserved motifs reveal details of ancestry and structure in the small TIM chaperones of the mitochondrial intermembrane space | journal = Molecular Biology and Evolution | volume = 24 | issue = 5 | pages = 1149–60 | date = May 2007 | pmid = 17329230 | doi = 10.1093/molbev/msm031 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=26517}}</ref>

== Function ==

This gene encodes a translocase with similarity to yeast mitochondrial proteins that are involved in the import of metabolite transporters from the cytoplasm and into the mitochondrial inner membrane. The encoded protein and the TIMM8a protein form a 70 kDa complex in the intermembrane space. This gene is in a head-to-tail orientation with the gene for lamin B2.<ref name="entrez" />

== Interactions ==

TIMM13 has been shown to interact with TIMM8A.<ref name=pmid17353931>{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | article-number = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}</ref><ref name=pmid11875042>{{cite journal | vauthors = Roesch K, Curran SP, Tranebjaerg L, Koehler CM | title = Human deafness dystonia syndrome is caused by a defect in assembly of the DDP1/TIMM8a-TIMM13 complex | journal = Human Molecular Genetics | volume = 11 | issue = 5 | pages = 477–86 | date = Mar 2002 | pmid = 11875042 | doi = 10.1093/hmg/11.5.477 | doi-access = free }}</ref>

== References == {{reflist}}

== Further reading == {{refbegin|33em}} * {{cite journal | vauthors = Rehling P, Wiedemann N, Pfanner N, Truscott KN | title = The mitochondrial import machinery for preproteins | journal = Critical Reviews in Biochemistry and Molecular Biology | volume = 36 | issue = 3 | pages = 291–336 | year = 2001 | pmid = 11450972 | doi = 10.1080/20014091074200 | s2cid = 8758017 }} * {{cite journal | vauthors = Paschen SA, Neupert W | title = Protein import into mitochondria | journal = IUBMB Life | volume = 52 | issue = 3–5 | pages = 101–12 | year = 2002 | pmid = 11798021 | doi = 10.1080/15216540152845894 | s2cid = 31047665 | doi-access = free }} * {{cite journal | vauthors = Neupert W, Brunner M | title = The protein import motor of mitochondria | journal = Nature Reviews. Molecular Cell Biology | volume = 3 | issue = 8 | pages = 555–65 | date = Aug 2002 | pmid = 12154367 | doi = 10.1038/nrm878 | s2cid = 5706589 }} * {{cite journal | vauthors = Jensen RE, Dunn CD | title = Protein import into and across the mitochondrial inner membrane: role of the TIM23 and TIM22 translocons | journal = Biochimica et Biophysica Acta (BBA) - Molecular Cell Research | volume = 1592 | issue = 1 | pages = 25–34 | date = Sep 2002 | pmid = 12191765 | doi = 10.1016/S0167-4889(02)00261-6 | doi-access = }} * {{cite journal | vauthors = Bauer MF, Rothbauer U, Mühlenbein N, Smith RJ, Gerbitz K, Neupert W, Brunner M, Hofmann S | title = The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom | journal = FEBS Letters | volume = 464 | issue = 1–2 | pages = 41–7 | date = Dec 1999 | pmid = 10611480 | doi = 10.1016/S0014-5793(99)01665-8 | bibcode = 1999FEBSL.464...41B | s2cid = 27484018 | doi-access = free }} * {{cite journal | vauthors = Paschen SA, Rothbauer U, Káldi K, Bauer MF, Neupert W, Brunner M | title = The role of the TIM8-13 complex in the import of Tim23 into mitochondria | journal = The EMBO Journal | volume = 19 | issue = 23 | pages = 6392–400 | date = Dec 2000 | pmid = 11101512 | pmc = 305865 | doi = 10.1093/emboj/19.23.6392 }} * {{cite journal | vauthors = Rothbauer U, Hofmann S, Mühlenbein N, Paschen SA, Gerbitz KD, Neupert W, Brunner M, Bauer MF | title = Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria | journal = The Journal of Biological Chemistry | volume = 276 | issue = 40 | pages = 37327–34 | date = Oct 2001 | pmid = 11489896 | doi = 10.1074/jbc.M105313200 | doi-access = free }} * {{cite journal | vauthors = Roesch K, Curran SP, Tranebjaerg L, Koehler CM | title = Human deafness dystonia syndrome is caused by a defect in assembly of the DDP1/TIMM8a-TIMM13 complex | journal = Human Molecular Genetics | volume = 11 | issue = 5 | pages = 477–86 | date = Mar 2002 | pmid = 11875042 | doi = 10.1093/hmg/11.5.477 | doi-access = free }} * {{cite journal | vauthors = Chacinska A, Pfanner N, Meisinger C | title = How mitochondria import hydrophilic and hydrophobic proteins | journal = Trends in Cell Biology | volume = 12 | issue = 7 | pages = 299–303 | date = Jul 2002 | pmid = 12185844 | doi = 10.1016/S0962-8924(02)02310-3 }} * {{cite journal | vauthors = Curran SP, Leuenberger D, Schmidt E, Koehler CM | title = The role of the Tim8p-Tim13p complex in a conserved import pathway for mitochondrial polytopic inner membrane proteins | journal = The Journal of Cell Biology | volume = 158 | issue = 6 | pages = 1017–27 | date = Sep 2002 | pmid = 12221072 | pmc = 2173223 | doi = 10.1083/jcb.200205124 }} * {{cite journal | vauthors = Roesch K, Hynds PJ, Varga R, Tranebjaerg L, Koehler CM | title = The calcium-binding aspartate/glutamate carriers, citrin and aralar1, are new substrates for the DDP1/TIMM8a-TIMM13 complex | journal = Human Molecular Genetics | volume = 13 | issue = 18 | pages = 2101–11 | date = Sep 2004 | pmid = 15254020 | doi = 10.1093/hmg/ddh217 | doi-access = free }} * {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | article-number = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }} {{refend}}