TAF1B

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''TATA box-binding protein-associated factor RNA polymerase I subunit B''' is an enzyme that in humans is encoded by the ''TAF1B'' gene.<ref name="pmid7801123">{{cite journal | vauthors = Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R | title = Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits | journal = Science | volume = 266 | issue = 5193 | pages = 1966–72 | date = January 1995 | pmid = 7801123 | doi = 10.1126/science.7801123 | bibcode = 1994Sci...266.1966C }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=9014}}</ref>

== Function ==

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs.<ref name="entrez" />

== Interactions ==

TAF1B has been shown to interact with RRN3.<ref name=pmid11250903>{{cite journal | vauthors = Miller G, Panov KI, Friedrich JK, Trinkle-Mulcahy L, Lamond AI, Zomerdijk JC | title = hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters | journal = EMBO J. | volume = 20 | issue = 6 | pages = 1373–82 | date = March 2001 | pmid = 11250903 | pmc = 145519 | doi = 10.1093/emboj/20.6.1373 }}</ref>

== References == {{Reflist}}

== Further reading == {{Refbegin | 2}} * {{cite journal | vauthors = Di Pietro C, Rapisarda A, Amico V, Bonaiuto C, Viola A, Scalia M, Motta S, Amato A, Engel H, Messina A, Sichel G, Grzeschik K, Purrello M | title = Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1 | journal = Cytogenet. Cell Genet. | volume = 89 | issue = 1–2 | pages = 133–6 | year = 2000 | pmid = 10894955 | doi = 10.1159/000015592 | s2cid = 27014629 }} * {{cite journal | vauthors = Zhai W, Comai L | title = Repression of RNA polymerase I transcription by the tumor suppressor p53 | journal = Mol. Cell. Biol. | volume = 20 | issue = 16 | pages = 5930–8 | year = 2000 | pmid = 10913176 | pmc = 86070 | doi = 10.1128/MCB.20.16.5930-5938.2000 }} * {{cite journal | vauthors = Miller G, Panov KI, Friedrich JK, Trinkle-Mulcahy L, Lamond AI, Zomerdijk JC | title = hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters | journal = EMBO J. | volume = 20 | issue = 6 | pages = 1373–82 | year = 2001 | pmid = 11250903 | pmc = 145519 | doi = 10.1093/emboj/20.6.1373 }} * {{cite journal | vauthors = Kim NG, Rhee H, Li LS, Kim H, Lee JS, Kim JH, Kim NK, Kim H | title = Identification of MARCKS, FLJ11383 and TAF1B as putative novel target genes in colorectal carcinomas with microsatellite instability | journal = Oncogene | volume = 21 | issue = 33 | pages = 5081–7 | year = 2002 | pmid = 12140758 | doi = 10.1038/sj.onc.1205703 | doi-access = free }} * {{cite journal | vauthors = Yuan X, Zhao J, Zentgraf H, Hoffmann-Rohrer U, Grummt I | title = Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter | journal = EMBO Rep. | volume = 3 | issue = 11 | pages = 1082–7 | year = 2002 | pmid = 12393749 | pmc = 1307603 | doi = 10.1093/embo-reports/kvf212 }} * {{cite journal | vauthors = Grandori C, Gomez-Roman N, Felton-Edkins ZA, Ngouenet C, Galloway DA, Eisenman RN, White RJ | title = c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I | journal = Nat. Cell Biol. | volume = 7 | issue = 3 | pages = 311–8 | year = 2005 | pmid = 15723054 | doi = 10.1038/ncb1224 | s2cid = 8913931 }} * {{cite journal | vauthors = You KT, Li LS, Kim NG, Kang HJ, Koh KH, Chwae YJ, Kim KM, Kim YK, Park SM, Jang SK, Kim H | title = Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors | journal = PLOS Biol. | volume = 5 | issue = 5 | pages = e109 | year = 2007 | pmid = 17456004 | pmc = 1854916 | doi = 10.1371/journal.pbio.0050109 | doi-access = free }} {{Refend}}