TAF13

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Transcription initiation factor TFIID subunit 13''' is a protein that in humans is encoded by the ''TAF13'' gene.<ref name="pmid7729427">{{cite journal | vauthors = Mengus G, May M, Jacq X, Staub A, Tora L, Chambon P, Davidson I | title = Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID | journal = EMBO J. | volume = 14 | issue = 7 | pages = 1520–31 | date = May 1995 | pmid = 7729427 | pmc = 398239 | doi = 10.1002/j.1460-2075.1995.tb07138.x}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=6884}}</ref>

== Function ==

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit associated with a subset of TFIID complexes. This subunit interacts with TBP and with two other small subunits of TFIID, TAF10 and TAF11. There is a pseudogene located on chromosome 6.<ref name="entrez" />

== Interactions ==

TAF13 has been shown to interact with TAF15,<ref name=pmid9488465>{{cite journal | vauthors = Bertolotti A, Melot T, Acker J, Vigneron M, Delattre O, Tora L | title = EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes | journal = Mol. Cell. Biol. | volume = 18 | issue = 3 | pages = 1489–97 | date = Mar 1998 | pmid = 9488465 | pmc = 108863 | doi=10.1128/mcb.18.3.1489}}</ref> TAF11,<ref name=pmid7729427 /><ref name=pmid9695952>{{cite journal | vauthors = Birck C, Poch O, Romier C, Ruff M, Mengus G, Lavigne AC, Davidson I, Moras D | title = Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family | journal = Cell | volume = 94 | issue = 2 | pages = 239–49 | date = Jul 1998 | pmid = 9695952 | doi = 10.1016/S0092-8674(00)81423-3 | s2cid = 6274415 | doi-access = free }}</ref> TAF10<ref name=pmid7729427/> and TATA binding protein.<ref name=pmid7729427/>

== References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Zhou Q, Sharp PA | title = Novel mechanism and factor for regulation by HIV-1 Tat | journal = EMBO J. | volume = 14 | issue = 2 | pages = 321–8 | year = 1995 | pmid = 7835343 | pmc = 398086 | doi = 10.1002/j.1460-2075.1995.tb07006.x}} * {{cite journal | vauthors = Parada CA, Yoon JB, Roeder RG | title = A novel LBP-1-mediated restriction of HIV-1 transcription at the level of elongation in vitro | journal = J. Biol. Chem. | volume = 270 | issue = 5 | pages = 2274–83 | year = 1995 | pmid = 7836461 | doi = 10.1074/jbc.270.5.2274 | doi-access = free }} * {{cite journal|author4-link=Richard Gaynor | vauthors = Ou SH, Garcia-Martínez LF, Paulssen EJ, Gaynor RB | title = Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function | journal = J. Virol. | volume = 68 | issue = 11 | pages = 7188–99 | year = 1994 | pmid = 7933101 | pmc = 237158 | doi = 10.1128/JVI.68.11.7188-7199.1994}} * {{cite journal | vauthors = Kashanchi F, Piras G, Radonovich MF, Duvall JF, Fattaey A, Chiang CM, Roeder RG, Brady JN | title = Direct interaction of human TFIID with the HIV-1 transactivator tat | journal = Nature | volume = 367 | issue = 6460 | pages = 295–9 | year = 1994 | pmid = 8121496 | doi = 10.1038/367295a0 | bibcode = 1994Natur.367..295K | s2cid = 4362048 }} * {{cite journal | vauthors = Wang Z, Morris GF, Rice AP, Xiong W, Morris CB | title = Wild-type and transactivation-defective mutants of human immunodeficiency virus type 1 Tat protein bind human TATA-binding protein in vitro | journal = J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. | volume = 12 | issue = 2 | pages = 128–38 | year = 1996 | pmid = 8680883 | doi = 10.1097/00042560-199606010-00005 | doi-access = free }} * {{cite journal | vauthors = Pendergrast PS, Morrison D, Tansey WP, Hernandez N | title = Mutations in the carboxy-terminal domain of TBP affect the synthesis of human immunodeficiency virus type 1 full-length and short transcripts similarly | journal = J. Virol. | volume = 70 | issue = 8 | pages = 5025–34 | year = 1996 | pmid = 8764009 | pmc = 190456 | doi = 10.1128/JVI.70.8.5025-5034.1996}} * {{cite journal | vauthors = Kashanchi F, Khleif SN, Duvall JF, Sadaie MR, Radonovich MF, Cho M, Martin MA, Chen SY, Weinmann R, Brady JN | title = Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex | journal = J. Virol. | volume = 70 | issue = 8 | pages = 5503–10 | year = 1996 | pmid = 8764062 | pmc = 190508 | doi = 10.1128/JVI.70.8.5503-5510.1996}} * {{cite journal | vauthors = Zhou Q, Sharp PA | title = Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat | journal = Science | volume = 274 | issue = 5287 | pages = 605–10 | year = 1996 | pmid = 8849451 | doi = 10.1126/science.274.5287.605 | bibcode = 1996Sci...274..605Z | s2cid = 13266489 }} * {{cite journal | vauthors = García-Martínez LF, Ivanov D, Gaynor RB | title = Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes | journal = J. Biol. Chem. | volume = 272 | issue = 11 | pages = 6951–8 | year = 1997 | pmid = 9054383 | doi = 10.1074/jbc.272.11.6951 | doi-access = free }} * {{cite journal | vauthors = Dantonel JC, Murthy KG, Manley JL, Tora L | title = Transcription factor TFIID recruits factor CPSF for formation of 3' end of mRNA | journal = Nature | volume = 389 | issue = 6649 | pages = 399–402 | year = 1997 | pmid = 9311784 | doi = 10.1038/38763 | bibcode = 1997Natur.389..399D | s2cid = 4413324 }} * {{cite journal | vauthors = Bertolotti A, Melot T, Acker J, Vigneron M, Delattre O, Tora L | title = EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes | journal = Mol. Cell. Biol. | volume = 18 | issue = 3 | pages = 1489–97 | year = 1998 | pmid = 9488465 | pmc = 108863 | doi = 10.1128/mcb.18.3.1489}} * {{cite journal | vauthors = Birck C, Poch O, Romier C, Ruff M, Mengus G, Lavigne AC, Davidson I, Moras D | title = Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family | journal = Cell | volume = 94 | issue = 2 | pages = 239–49 | year = 1998 | pmid = 9695952 | doi = 10.1016/S0092-8674(00)81423-3 | s2cid = 6274415 | doi-access = free }} * {{cite journal | vauthors = Imabayashi H, Mori T, Gojo S, Kiyono T, Sugiyama T, Irie R, Isogai T, Hata J, Toyama Y, Umezawa A | title = Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis | journal = Exp. Cell Res. | volume = 288 | issue = 1 | pages = 35–50 | year = 2003 | pmid = 12878157 | doi = 10.1016/S0014-4827(03)00130-7 }} {{refend}}

== External links == * {{PDBe-KB2|Q15543|Transcription initiation factor TFIID subunit 13}}