{{Short description|American biochemist}} {{Use mdy dates|date=April 2026}} {{Infobox scientist | name = | image = <!--(filename only, i.e. without "File:" prefix)--> | birth_date = <!--{{birth date |YYYY|MM|DD}}--> | birth_place = | death_date = <!--{{death date and age |YYYY|MM|DD |YYYY|MM|DD}} (death date then birth date)--> | death_place = | death_cause = | citizenship = | nationality = | fields = Biochemistry | workplaces = {{plainlist| * Fred Hutchinson Cancer Research Center * }} | education = | alma_mater = {{plainlist| * University of Chicago * Harvard University }} | known_for = BLOSUM | awards = | spouse = Jorja Henikoff | children = }} '''Steven Henikoff''' is a scientist at the Fred Hutchinson Cancer Research Center, and an HHMI Investigator.<ref>{{cite web|url=http://research.fhcrc.org/henikoff/en.html|title=HENIKOFF LAB|website=research.fhcrc.org}}</ref> His field of study is chromatin-related transcriptional regulation.<ref>{{Cite web|url=http://www.hhmi.org/scientists/steven-henikoff|title = Steven Henikoff}}</ref> He earned his BS in chemistry at the University of Chicago. He earned his PhD in biochemistry and molecular biology from Harvard University in the lab of Matt Meselson in 1977. He did a postdoctoral fellowship at the University of Washington.<ref>{{cite web|url=https://sharedresources.fredhutch.org/profile/henikoff-steven|title=Steven Henikoff – Fred Hutchinson Cancer Research Center Researcher Profiles Arnold Library and Shared Resources|website=sharedresources.fredhutch.org}}</ref> His research has been funded by the National Science Foundation, National Institutes of Health, and HHMI. In 1992, Steven Henikoff, together with his wife Jorja Henikoff, introduced the BLOSUM substitution matrices.<ref name=henikoff>{{cite journal| year=1992| journal=PNAS | volume=89 | pages=10915–10919| pmid=1438297 | title = Amino Acid Substitution Matrices from Protein Blocks | doi = 10.1073/pnas.89.22.10915 | author = Henikoff, S. |author2=Henikoff, J.G.| issue=22| pmc=50453| bibcode=1992PNAS...8910915H | doi-access=free }}</ref> The BLOSUM matrices are widely used for sequence alignment of proteins.<ref name=azar>{{cite journal| year=2007| journal=PNAS | volume=104 | pages=19665–19667| pmid=18077398 | title = Profile of Steven Henikoff | doi = 10.1073/pnas.0710322104 | author = Azar, B. | issue=50| pmc=2148353| bibcode=2007PNAS..10419665A | doi-access=free }}</ref> In 2005, Henikoff was elected to the National Academy of Sciences.<ref>{{cite web|url=https://www.fredhutch.org/en/diseases/featured-researchers/henikoff-steven.html|title=Steve Henikoff, geneticist and inventor|website=Fred Hutch|access-date=November 21, 2016|archive-date=December 24, 2018|archive-url=https://web.archive.org/web/20181224220120/https://www.fredhutch.org/en/diseases/featured-researchers/henikoff-steven.html|url-status=dead}}</ref>
In 2025 Steven Henikoff was awarded the Rosenstiel Award for his transformative research on genome organization and gene expression.<ref>[https://www.brandeis.edu/rosenstiel/rosenstiel-award/ Rosenstiel Award 2025]</ref>
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