Sise is a surname. Notable people with the surname include:
- Charles Fleetford Sise, Sr, Canadian businessman
- Charles Fleetford Sise Jr, Canadian businessman
- Edward Fleetford Sise, Canadian businessman
- Joe Sise (born 1989), Swedish footballer
- Paul Fleetford Sise, Canadian businessman
See also
- Si*Sé, an electronic music group from the US
- Sisse, a Danish female given name
- Size (disambiguation)