Shupe may refer to:
Place names
- Shupe, Virginia, U.S.
- Shupe Peak, Victoria Land, Antarctica
People with the surname
- Anson Shupe (1948–2015), American sociologist
- Bryan Shupe, American politician
- Elisa Rae Shupe (1963-2025), American soldier
- Ryan Shupe, American musician
- Vince Shupe (1921–1962), Major League Baseball first baseman
Fictional characters
- Glen Shupe, an Irish drug addict featuring in the HBO television series Oz