SPRY1

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Protein sprouty homolog 1''' is a protein that in humans is encoded by the ''SPRY1'' gene.<ref name="pmid9458049">{{cite journal | vauthors = Hacohen N, Kramer S, Sutherland D, Hiromi Y, Krasnow MA | title = sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways | journal = Cell | volume = 92 | issue = 2 | pages = 253–63 | date = January 1998 | pmid = 9458049 | doi = 10.1016/S0092-8674(00)80919-8 | s2cid = 498977 | doi-access = free }}</ref><ref name="pmid15962011">{{cite journal | vauthors = Haglund K, Schmidt MH, Wong ES, Guy GR, Dikic I | title = Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation | journal = EMBO Reports | volume = 6 | issue = 7 | pages = 635–41 | date = July 2005 | pmid = 15962011 | pmc = 1369112 | doi = 10.1038/sj.embor.7400453 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=10252}}</ref>

== See also == *Neurofibromin 1 *SPRED1

== References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Lim J, Wong ES, Ong SH, Yusoff P, Low BC, Guy GR | title = Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain | journal = The Journal of Biological Chemistry | volume = 275 | issue = 42 | pages = 32837–45 | date = October 2000 | pmid = 10887178 | doi = 10.1074/jbc.M002156200 | doi-access = free }} * {{cite journal | vauthors = Egan JE, Hall AB, Yatsula BA, Bar-Sagi D | title = The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 9 | pages = 6041–6 | date = April 2002 | pmid = 11983899 | pmc = 122898 | doi = 10.1073/pnas.052090899 | bibcode = 2002PNAS...99.6041E | doi-access = free }} * {{cite journal | vauthors = Hanafusa H, Torii S, Yasunaga T, Nishida E | title = Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway | journal = Nature Cell Biology | volume = 4 | issue = 11 | pages = 850–8 | date = November 2002 | pmid = 12402043 | doi = 10.1038/ncb867 | s2cid = 31064800 }} * {{cite journal | vauthors = Di Y, Li J, Zhang Y, He X, Lu H, Xu D, Ling J, Huo K, Wan D, Li YY, Gu J | display-authors = 6 | title = HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins | journal = Journal of Biochemistry | volume = 133 | issue = 6 | pages = 713–8 | date = June 2003 | pmid = 12869526 | doi = 10.1093/jb/mvg091 | doi-access = free }} * {{cite journal | vauthors = Wang L, Ji C, Wu H, Xu J, Wu Q, Dai J, Yin G, Ye X, Gu S, Xie Y, Mao Y | display-authors = 6 | title = Identification and expression analysis of a novel splice variant of human Sprouty1 gene | journal = International Journal of Molecular Medicine | volume = 12 | issue = 5 | pages = 783–7 | date = November 2003 | pmid = 14533010 | doi = 10.3892/ijmm.12.5.783 }} * {{cite journal | vauthors = Anteby EY, Natanson-Yaron S, Greenfield C, Goldman-Wohl D, Haimov-Kochman R, Holzer H, Yagel S | title = Human placental Hofbauer cells express sprouty proteins: a possible modulating mechanism of villous branching | journal = Placenta | volume = 26 | issue = 6 | pages = 476–83 | date = July 2005 | pmid = 15950061 | doi = 10.1016/j.placenta.2004.08.008 }} * {{cite journal | vauthors = Cabrita MA, Jäggi F, Widjaja SP, Christofori G | title = A functional interaction between sprouty proteins and caveolin-1 | journal = The Journal of Biological Chemistry | volume = 281 | issue = 39 | pages = 29201–12 | date = September 2006 | pmid = 16877379 | doi = 10.1074/jbc.M603921200 | doi-access = free }} * {{cite journal | vauthors = Fritzsche S, Kenzelmann M, Hoffmann MJ, Müller M, Engers R, Gröne HJ, Schulz WA | title = Concomitant down-regulation of SPRY1 and SPRY2 in prostate carcinoma | journal = Endocrine-Related Cancer | volume = 13 | issue = 3 | pages = 839–49 | date = September 2006 | pmid = 16954433 | doi = 10.1677/erc.1.01190 | doi-access = free }} * {{cite journal | vauthors = Schaaf G, Hamdi M, Zwijnenburg D, Lakeman A, Geerts D, Versteeg R, Kool M | title = Silencing of SPRY1 triggers complete regression of rhabdomyosarcoma tumors carrying a mutated RAS gene | journal = Cancer Research | volume = 70 | issue = 2 | pages = 762–71 | date = January 2010 | pmid = 20068162 | doi = 10.1158/0008-5472.CAN-09-2532 | doi-access = free }} * {{cite journal | vauthors = Charles NJ, Huebert RC, Lee S, Adhikari N, Polster S, Rider JE, Braunlin E, Mariash A, Robledo M, Schuweiler D, Hall JL | display-authors = 6 | title = Targeted Sprouty1 overexpression in cardiac myocytes does not alter myocardial remodeling or function | journal = Molecular and Cellular Biochemistry | volume = 342 | issue = 1–2 | pages = 57–62 | date = September 2010 | pmid = 20461448 | pmc = 2923832 | doi = 10.1007/s11010-010-0468-8 }} {{refend}}

== External links == * {{UCSC genome browser|SPRY1}} * {{UCSC gene details|SPRY1}}

Category:SPR domain Category:Human proteins