{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Kunitz-type protease inhibitor 2''' is an enzyme inhibitor that in humans is encoded by the ''SPINT2'' gene.<ref name="pmid9115294">{{cite journal | vauthors = Marlor CW, Delaria KA, Davis G, Muller DK, Greve JM, Tamburini PP | title = Identification and cloning of human placental bikunin, a novel serine protease inhibitor containing two Kunitz domains | journal = The Journal of Biological Chemistry | volume = 272 | issue = 18 | pages = 12202–8 | date = May 1997 | pmid = 9115294 | doi = 10.1074/jbc.272.18.12202 | doi-access = free }}</ref><ref name="pmid9346890">{{cite journal | vauthors = Kawaguchi T, Qin L, Shimomura T, Kondo J, Matsumoto K, Denda K, Kitamura N | title = Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor | journal = The Journal of Biological Chemistry | volume = 272 | issue = 44 | pages = 27558–64 | date = Oct 1997 | pmid = 9346890 | doi = 10.1074/jbc.272.44.27558 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SPINT2 serine peptidase inhibitor, Kunitz type, 2| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=10653}}</ref> SPINT2 is a transmembrane protein with two extracellular Kunitz domains to inhibit serine proteases. This gene is a presumed tumor suppressor by inhibiting HGF activator which prevents the formation of active hepatocyte growth factor. Mutations in SPINT2 could result in congenital sodium diarrhea (CSD).
== References ==
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== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Morelle W, Capon C, Balduyck M, Sautiere P, Kouach M, Michalski C, Fournet B, Mizon J | title = Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor | journal = European Journal of Biochemistry | volume = 221 | issue = 2 | pages = 881–8 | date = Apr 1994 | pmid = 7513643 | doi = 10.1111/j.1432-1033.1994.tb18803.x }} * {{cite journal | vauthors = Mizon C, Balduyck M, Albani D, Michalski C, Burnouf T, Mizon J | title = Development of an enzyme-linked immunosorbent assay for human plasma inter-alpha-trypsin inhibitor (ITI) using specific antibodies against each of the H1 and H2 heavy chains | journal = Journal of Immunological Methods | volume = 190 | issue = 1 | pages = 61–70 | date = Mar 1996 | pmid = 8601712 | doi = 10.1016/0022-1759(95)00257-X }} * {{cite journal | vauthors = Gress TM, Müller-Pillasch F, Geng M, Zimmerhackl F, Zehetner G, Friess H, Büchler M, Adler G, Lehrach H | title = A pancreatic cancer-specific expression profile | journal = Oncogene | volume = 13 | issue = 8 | pages = 1819–30 | date = Oct 1996 | pmid = 8895530 }} * {{cite journal | vauthors = Shimomura T, Denda K, Kitamura A, Kawaguchi T, Kito M, Kondo J, Kagaya S, Qin L, Takata H, Miyazawa K, Kitamura N | title = Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor | journal = The Journal of Biological Chemistry | volume = 272 | issue = 10 | pages = 6370–6 | date = Mar 1997 | pmid = 9045658 | doi = 10.1074/jbc.272.10.6370 | doi-access = free }} * {{cite journal | vauthors = Blom AM, Thuveson M, Fries E | title = Intracellular coupling of bikunin and the heavy chain of rat pre-alpha-inhibitor in COS-1 cells | journal = The Biochemical Journal | volume = 328 ( Pt 1) | issue = Pt 1 | pages = 185–91 | date = Nov 1997 | pmid = 9359851 | pmc = 1218904 | doi = 10.1042/bj3280185}} * {{cite journal | vauthors = Müller-Pillasch F, Wallrapp C, Bartels K, Varga G, Friess H, Büchler M, Adler G, Gress TM | title = Cloning of a new Kunitz-type protease inhibitor with a putative transmembrane domain overexpressed in pancreatic cancer | journal = Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | volume = 1395 | issue = 1 | pages = 88–95 | date = Jan 1998 | pmid = 9434156 | doi = 10.1016/s0167-4781(97)00129-2 }} * {{cite journal | vauthors = Kataoka H, Shimomura T, Kawaguchi T, Hamasuna R, Itoh H, Kitamura N, Miyazawa K, Koono M | title = Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment | journal = The Journal of Biological Chemistry | volume = 275 | issue = 51 | pages = 40453–62 | date = Dec 2000 | pmid = 11013244 | doi = 10.1074/jbc.M006412200 | doi-access = free }} * {{cite journal | vauthors = Itoh H, Kataoka H, Yamauchi M, Naganuma S, Akiyama Y, Nuki Y, Shimomura T, Miyazawa K, Kitamura N, Koono M | title = Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes | journal = Biochemical and Biophysical Research Communications | volume = 288 | issue = 2 | pages = 390–9 | date = Oct 2001 | pmid = 11606055 | doi = 10.1006/bbrc.2001.5767 | bibcode = 2001BBRC..288..390I }} * {{cite journal | vauthors = Suzuki M, Kobayashi H, Fujie M, Nishida T, Takigawa M, Kanayama N, Terao T | title = Kunitz-type protease inhibitor bikunin disrupts phorbol ester-induced oligomerization of CD44 variant isoforms containing epitope v9 and subsequently suppresses expression of urokinase-type plasminogen activator in human chondrosarcoma cells | journal = The Journal of Biological Chemistry | volume = 277 | issue = 10 | pages = 8022–32 | date = Mar 2002 | pmid = 11777908 | doi = 10.1074/jbc.M108545200 | doi-access = free }} * {{cite journal | vauthors = Kobayashi H, Suzuki M, Kanayama N, Nishida T, Takigawa M, Terao T | title = Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade | journal = European Journal of Biochemistry | volume = 269 | issue = 16 | pages = 3945–57 | date = Aug 2002 | pmid = 12180971 | doi = 10.1046/j.1432-1033.2002.03068.x | doi-access = free }} * {{cite journal | vauthors = Mizon C, Piva F, Queyrel V, Balduyck M, Hachulla E, Mizon J | title = Urinary bikunin determination provides insight into proteinase/proteinase inhibitor imbalance in patients with inflammatory diseases | journal = Clinical Chemistry and Laboratory Medicine | volume = 40 | issue = 6 | pages = 579–86 | date = Jun 2002 | pmid = 12211652 | doi = 10.1515/CCLM.2002.100 | s2cid = 22630736 }} * {{cite journal | vauthors = Isogai R, Matsukura A, Aragane Y, Maeda A, Matsukura M, Yudate T, Sugihara K, Takahashi M, Aisu K, Tezuka T | title = Quantitative analysis of bikunin-laden mast cells in follicular eruptions and chronic skin lesions of atopic dermatitis | journal = Archives of Dermatological Research | volume = 294 | issue = 9 | pages = 387–92 | date = Dec 2002 | pmid = 12522575 | doi = 10.1007/s00403-002-0336-9 | s2cid = 9514861 }} * {{cite journal | vauthors = Yamauchi M, Itoh H, Naganuma S, Koono M, Hasui Y, Osada Y, Kataoka H | title = Expression of hepatocyte growth factor activator inhibitor type 2 (HAI-2) in human testis: identification of a distinct transcription start site for the HAI-2 gene in testis | journal = Biological Chemistry | volume = 383 | issue = 12 | pages = 1953–7 | date = Dec 2002 | pmid = 12553733 | doi = 10.1515/BC.2002.220 | s2cid = 19734313 }} * {{cite journal | vauthors = Suzuki M, Kobayashi H, Tanaka Y, Hirashima Y, Kanayama N, Takei Y, Saga Y, Suzuki M, Itoh H, Terao T | title = Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cell line by overexpression of bikunin | journal = International Journal of Cancer | volume = 104 | issue = 3 | pages = 289–302 | date = Apr 2003 | pmid = 12569552 | doi = 10.1002/ijc.10950 | hdl = 10271/1250 | s2cid = 84583247 | hdl-access = free }} * {{cite journal | vauthors = Suzuki M, Kobayashi H, Tanaka Y, Hirashima Y, Kanayama N, Takei Y, Saga Y, Suzuki M, Itoh H, Terao T | title = Bikunin target genes in ovarian cancer cells identified by microarray analysis | journal = The Journal of Biological Chemistry | volume = 278 | issue = 17 | pages = 14640–6 | date = Apr 2003 | pmid = 12571229 | doi = 10.1074/jbc.M300239200 | doi-access = free }} * {{cite journal | vauthors = Schuster JM, Longo M, Nelson PS | title = Differential expression of bikunin (HAI-2/PB), a proposed mediator of glioma invasion, by demethylation treatment | journal = Journal of Neuro-Oncology | volume = 64 | issue = 3 | pages = 219–25 | date = Sep 2003 | pmid = 14558597 | doi = 10.1023/A:1025674227750 | s2cid = 22607445 }} * {{cite journal | vauthors = Fukai K, Yokosuka O, Chiba T, Hirasawa Y, Tada M, Imazeki F, Kataoka H, Saisho H | title = Hepatocyte growth factor activator inhibitor 2/placental bikunin (HAI-2/PB) gene is frequently hypermethylated in human hepatocellular carcinoma | journal = Cancer Research | volume = 63 | issue = 24 | pages = 8674–9 | date = Dec 2003 | pmid = 14695180 }} {{refend}}
== External links == * {{PDBe-KB2|O43291|Kunitz-type protease inhibitor 2}}
{{gene-19-stub}}