SMG5 — Mediated Wiki

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Protein SMG5''' is a protein that in humans is encoded by the ''SMG5'' gene.<ref name="pmid12676087">{{cite journal | vauthors = Reichenbach P, Hoss M, Azzalin CM, Nabholz M, Bucher P, Lingner J | title = A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed | journal = Curr Biol | volume = 13 | issue = 7 | pages = 568–74 |date=Apr 2003 | pmid = 12676087 | doi =10.1016/S0960-9822(03)00173-8 | s2cid = 14423276 | doi-access = free }}</ref><ref name="pmid12699629">{{cite journal | vauthors = Snow BE, Erdmann N, Cruickshank J, Goldman H, Gill RM, Robinson MO, Harrington L | title = Functional conservation of the telomerase protein Est1p in humans | journal = Curr Biol | volume = 13 | issue = 8 | pages = 698–704 |date=Apr 2003 | pmid = 12699629 | doi =10.1016/S0960-9822(03)00210-0 | s2cid = 6685276 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SMG5 Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=23381}}</ref> This protein contains a PIN domain that appears to have mutated the residues in the active site.<ref name="pmid17053788">{{cite journal |vauthors=Glavan F, Behm-Ansmant I, Izaurralde E, Conti E |title=Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex |journal=EMBO J. |volume=25 |issue=21 |pages=5117–25 |date=November 2006 |pmid=17053788 |pmc=1630413 |doi=10.1038/sj.emboj.7601377 }}</ref>

==References== {{reflist}}

==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Nakajima D, Okazaki N, Yamakawa H, etal |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 |doi-access=free }} *{{cite journal |vauthors=Kikuno R, Nagase T, Ishikawa K, etal |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197–205 |year= 1999 |pmid= 10470851 |doi=10.1093/dnares/6.3.197 |doi-access=free }} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Ohnishi T, Yamashita A, Kashima I, etal |title=Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. |journal=Mol. Cell |volume=12 |issue= 5 |pages= 1187–200 |year= 2004 |pmid= 14636577 |doi=10.1016/S1097-2765(03)00443-X |doi-access=free }} *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }} *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} *{{cite journal | vauthors=Unterholzner L, Izaurralde E |title=SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. |journal=Mol. Cell |volume=16 |issue= 4 |pages= 587–96 |year= 2005 |pmid= 15546618 |doi= 10.1016/j.molcel.2004.10.013 |doi-access= free }} *{{cite journal |vauthors=Fukuhara N, Ebert J, Unterholzner L, etal |title=SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. |journal=Mol. Cell |volume=17 |issue= 4 |pages= 537–47 |year= 2005 |pmid= 15721257 |doi= 10.1016/j.molcel.2005.01.010 |doi-access= free }} *{{cite journal | vauthors=Azzalin CM, Lingner J |title=The human RNA surveillance factor UPF1 is required for S phase progression and genome stability. |journal=Curr. Biol. |volume=16 |issue= 4 |pages= 433–9 |year= 2006 |pmid= 16488880 |doi= 10.1016/j.cub.2006.01.018 |s2cid=17197870 |doi-access=free }} *{{cite journal |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |bibcode=2006Natur.441..315G |doi-access= free }} *{{cite journal |vauthors=Lee H, Sengupta N, Villagra A, etal |title=Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation. |journal=Mol. Cell. Biol. |volume=26 |issue= 14 |pages= 5259–69 |year= 2006 |pmid= 16809764 |doi= 10.1128/MCB.01971-05 | pmc=1592721 }} {{refend}} {{PDB Gallery|geneid=23381}}