SLURP1

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Secreted Ly-6/uPAR-related protein 1''' is a protein that in humans is encoded by the ''SLURP1'' gene.<ref name="pmid11285253">{{cite journal | vauthors = Fischer J, Bouadjar B, Heilig R, Huber M, Lefèvre C, Jobard F, Macari F, Bakija-Konsuo A, Ait-Belkacem F, Weissenbach J, Lathrop M, Hohl D, Prud'homme JF | title = Mutations in the gene encoding SLURP-1 in Mal de Meleda | journal = Human Molecular Genetics | volume = 10 | issue = 8 | pages = 875–80 | date = April 2001 | pmid = 11285253 | doi = 10.1093/hmg/10.8.875 | doi-access = free }}</ref><ref name="pmid10211827">{{cite journal | vauthors = Adermann K, Wattler F, Wattler S, Heine G, Meyer M, Forssmann WG, Nehls M | title = Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily | journal = Protein Science | volume = 8 | issue = 4 | pages = 810–9 | date = April 1999 | pmid = 10211827 | pmc = 2144295 | doi = 10.1110/ps.8.4.810 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLURP1 secreted LY6/PLAUR domain containing 1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=57152}}</ref> It exerts anti-inflammatory effects, acts as a tumor suppressor, and antagonizes nicotinic receptors.<ref name=":0">{{cite journal | vauthors = Throm VM, Männle D, Giese T, Bauer AS, Gaida MM, Kopitz J, Bruckner T, Plaschke K, Grekova SP, Felix K, Hackert T, Giese NA, Strobel O | title = Endogenous CHRNA7-ligand SLURP1 as a potential tumor suppressor and anti-nicotinic factor in pancreatic cancer | journal = Oncotarget | volume = 9 | issue = 14 | pages = 11734–11751 | date = February 2018 | pmid = 29545933 | pmc = 5837762 | doi = 10.18632/oncotarget.24312 }}</ref>

== Function ==

The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is secreted into the blood<ref name="pmid10211827" /> and is also sometimes found in semen when extracted into the female zygote which binds to the α7-acetylcholine receptor.<ref name=":0" /> It is shown to act as an endogenous tumor suppressor by reducing cell migration and invasion by mediating its own anti-tumor effect and by antagonizing the pro-malignant effects of nicotine.<ref name=":0" />

Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder characterized by an inflammatory palmoplantar hyperkeratosis. This is the consequence of a loss of SLURP1 which leads to a dysfunctional epithelial differentiation<ref>{{cite journal | vauthors = Favre B, Plantard L, Aeschbach L, Brakch N, Christen-Zaech S, de Viragh PA, Sergeant A, Huber M, Hohl D | title = SLURP1 is a late marker of epidermal differentiation and is absent in Mal de Meleda | journal = The Journal of Investigative Dermatology | volume = 127 | issue = 2 | pages = 301–8 | date = February 2007 | pmid = 17008884 | doi = 10.1038/sj.jid.5700551 | doi-access = free }}</ref> and an increased secretion of the inflammatory cytokines TNFα, IL1, IL-6, and IL-8.<ref>{{cite journal | vauthors = Swamynathan S, Buela KA, Kinchington P, Lathrop KL, Misawa H, Hendricks RL, Swamynathan SK | title = Klf4 regulates the expression of Slurp1, which functions as an immunomodulatory peptide in the mouse cornea | journal = Investigative Ophthalmology & Visual Science | volume = 53 | issue = 13 | pages = 8433–46 | date = December 2012 | pmid = 23139280 | pmc = 4113333 | doi = 10.1167/iovs.12-10759 }}</ref><ref>{{cite journal | vauthors = Chernyavsky AI, Galitovskiy V, Shchepotin IB, Grando SA | title = Anti-inflammatory effects of the nicotinergic peptides SLURP-1 and SLURP-2 on human intestinal epithelial cells and immunocytes | journal = BioMed Research International | volume = 2014 | article-number = 609086 | date = 2014 | pmid = 24877120 | pmc = 4024406 | doi = 10.1155/2014/609086 | doi-access = free }}</ref>

This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors.<ref name="entrez" />

== References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Ridge RJ, Sloane NH | title = Partial N-terminal amino acid sequence of the anti-neoplastic urinary protein (ANUP) and the anti-tumour effect of the N-terminal nonapeptide of the unique cytokine present in human granulocytes | journal = Cytokine | volume = 8 | issue = 1 | pages = 1–5 | date = January 1996 | pmid = 8742060 | doi = 10.1006/cyto.1996.0001 }} * {{cite journal | vauthors = Fischer J, Bouadjar B, Heilig R, Fizames C, Prud'homme JF, Weissenbach J | title = Genetic linkage of Meleda disease to chromosome 8qter | journal = European Journal of Human Genetics | volume = 6 | issue = 6 | pages = 542–7 | year = 1999 | pmid = 9887370 | doi = 10.1038/sj.ejhg.5200254 | doi-access = free }} * {{cite journal | vauthors = Eckl KM, Stevens HP, Lestringant GG, Westenberger-Treumann M, Traupe H, Hinz B, Frossard PM, Stadler R, Leigh IM, Nürnberg P, Reis A, Hennies HC | title = Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates | journal = Human Genetics | volume = 112 | issue = 1 | pages = 50–6 | date = January 2003 | pmid = 12483299 | doi = 10.1007/s00439-002-0838-8 | s2cid = 317308 }} * {{cite journal | vauthors = Marrakchi S, Audebert S, Bouadjar B, Has C, Lefèvre C, Munro C, Cure S, Jobard F, Morlot S, Hohl D, Prud'homme JF, Zahaf A, Turki H, Fischer J | title = Novel mutations in the gene encoding secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related protein-1 (SLURP-1) and description of five ancestral haplotypes in patients with Mal de Meleda | journal = The Journal of Investigative Dermatology | volume = 120 | issue = 3 | pages = 351–5 | date = March 2003 | pmid = 12603845 | doi = 10.1046/j.1523-1747.2003.12062.x | doi-access = free }} * {{cite journal | vauthors = Hu G, Yildirim M, Baysal V, Yerebakan O, Yilmaz E, Inaloz HS, Martinez-Mir A, Christiano AM, Celebi JT | title = A recurrent mutation in the ARS (component B) gene encoding SLURP-1 in Turkish families with mal de Meleda: evidence of a founder effect | journal = The Journal of Investigative Dermatology | volume = 120 | issue = 6 | pages = 967–9 | date = June 2003 | pmid = 12787122 | doi = 10.1046/j.1523-1747.2003.12248.x | hdl = 10261/39458 | hdl-access = free }} * {{cite journal | vauthors = Chimienti F, Hogg RC, Plantard L, Lehmann C, Brakch N, Fischer J, Huber M, Bertrand D, Hohl D | title = Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda | journal = Human Molecular Genetics | volume = 12 | issue = 22 | pages = 3017–24 | date = November 2003 | pmid = 14506129 | doi = 10.1093/hmg/ddg320 | doi-access = free }} * {{cite journal | vauthors = Charfeddine C, Mokni M, Ben Mousli R, Elkares R, Bouchlaka C, Boubaker S, Ghedamsi S, Baccouche D, Ben Osman A, Dellagi K, Abdelhak S | title = A novel missense mutation in the gene encoding SLURP-1 in patients with Mal de Meleda from northern Tunisia | journal = The British Journal of Dermatology | volume = 149 | issue = 6 | pages = 1108–15 | date = December 2003 | pmid = 14674887 | doi = 10.1111/j.1365-2133.2003.05606.x | s2cid = 22999382 }} * {{cite journal | vauthors = Mastrangeli R, Donini S, Kelton CA, He C, Bressan A, Milazzo F, Ciolli V, Borrelli F, Martelli F, Biffoni M, Serlupi-Crescenzi O, Serani S, Micangeli E, El Tayar N, Vaccaro R, Renda T, Lisciani R, Rossi M, Papoian R | title = ARS Component B: structural characterization, tissue expression and regulation of the gene and protein (SLURP-1) associated with Mal de Meleda | journal = European Journal of Dermatology | volume = 13 | issue = 6 | pages = 560–70 | year = 2004 | pmid = 14721776 }} * {{cite journal | vauthors = Mokni M, Charfeddine C, Ben Mously R, Baccouche D, Kaabi B, Ben Osman A, Dellagi K, Abdelhak S | title = Heterozygous manifestations in female carriers of Mal de Meleda | journal = Clinical Genetics | volume = 65 | issue = 3 | pages = 244–6 | date = March 2004 | pmid = 14756676 | doi = 10.1111/j.0009-9163.2004.00224.x | s2cid = 46140052 }} * {{cite journal | vauthors = Chao SC, Lai FJ, Yang MH, Lee JY | title = Mal de Meleda in a taiwanese | journal = Journal of the Formosan Medical Association = Taiwan Yi Zhi | volume = 104 | issue = 4 | pages = 276–8 | date = April 2005 | pmid = 15909066 }} * {{cite journal | vauthors = Arredondo J, Chernyavsky AI, Webber RJ, Grando SA | title = Biological effects of SLURP-1 on human keratinocytes | journal = The Journal of Investigative Dermatology | volume = 125 | issue = 6 | pages = 1236–41 | date = December 2005 | pmid = 16354194 | doi = 10.1111/j.0022-202X.2005.23973.x | doi-access = free }} * {{cite journal | vauthors = Arredondo J, Chernyavsky AI, Grando SA | title = Overexpression of SLURP-1 and -2 alleviates the tumorigenic action of tobacco-derived nitrosamine on immortalized oral epithelial cells | journal = Biochemical Pharmacology | volume = 74 | issue = 8 | pages = 1315–9 | date = October 2007 | pmid = 17643396 | pmc = 2046218 | doi = 10.1016/j.bcp.2007.06.026 }} {{refend}}