Solute carrier organic anion transporter family member 2A1

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Solute carrier organic anion transporter family member 2A1''', also known as the '''prostaglandin transporter''' (PGT), is a protein that in humans is encoded by the SLCO2A1 gene.<ref name="entrez">{{cite web | title = Entrez Gene: Solute carrier organic anion transporter family, member 2A1| url = https://www.ncbi.nlm.nih.gov/gene?db=gene&cmd=retrieve&list_uids=6578| access-date = 2011-12-30  }}</ref>

This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning organic anion-transporting polypeptide superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues.<ref name="entrez"/>

==Clinical relevance== Mutations in this gene have been shown to cause primary hypertrophic osteoarthropathy,<ref name="pmid22197487">{{cite journal | vauthors = Zhang Z, Xia W, He J, Zhang Z, Ke Y, Yue H, Wang C, Zhang H, Gu J, Hu W, Fu W, Hu Y, Li M, Liu Y | title = Exome sequencing identifies SLCO2A1 mutations as a cause of primary hypertrophic osteoarthropathy | journal = American Journal of Human Genetics | volume = 90 | issue = 1 | pages = 125–32 | date = January 2012 | pmid = 22197487 | doi = 10.1016/j.ajhg.2011.11.019 | pmc = 3257902 }}</ref> specific form of chronic enteropathy.

== References == {{reflist}}

==Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Hagenbuch B, Meier PJ | title = Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties | journal = Pflügers Archiv | volume = 447 | issue = 5 | pages = 653–65 | date = February 2004 | pmid = 14579113 | doi = 10.1007/s00424-003-1168-y | s2cid = 21837213 | url = http://doc.rero.ch/record/311573/files/424_2003_Article_1168.pdf }} * {{cite journal | vauthors = Huang CS, Huang MJ, Lin MS, Yang SS, Teng HC, Tang KS | title = Genetic factors related to unconjugated hyperbilirubinemia amongst adults | journal = Pharmacogenetics and Genomics | volume = 15 | issue = 1 | pages = 43–50 | date = January 2005 | pmid = 15864125 | doi = 10.1097/01213011-200501000-00007 | s2cid = 24247125 }} * {{cite journal | vauthors = Kang J, Chapdelaine P, Laberge PY, Fortier MA | title = Functional characterization of prostaglandin transporter and terminal prostaglandin synthases during decidualization of human endometrial stromal cells | journal = Human Reproduction | volume = 21 | issue = 3 | pages = 592–9 | date = March 2006 | pmid = 16339169 | doi = 10.1093/humrep/dei400 | s2cid = 6008841 | doi-access = free }} * {{cite journal | vauthors = Choi K, Zhuang H, Crain B, Doré S | title = Expression and localization of prostaglandin transporter in Alzheimer disease brains and age-matched controls | journal = Journal of Neuroimmunology | volume = 195 | issue = 1–2 | pages = 81–7 | date = March 2008 | pmid = 18353443 | pmc = 2365511 | doi = 10.1016/j.jneuroim.2008.01.014 }} * {{cite journal | vauthors = Holla VR, Backlund MG, Yang P, Newman RA, DuBois RN | title = Regulation of prostaglandin transporters in colorectal neoplasia | journal = Cancer Prevention Research | volume = 1 | issue = 2 | pages = 93–9 | date = July 2008 | pmid = 19138942 | doi = 10.1158/1940-6207.CAPR-07-0009 | doi-access = free }} * {{cite journal | vauthors = Chi Y, Schuster VL | title = The prostaglandin transporter PGT transports PGH(2) | journal = Biochemical and Biophysical Research Communications | volume = 395 | issue = 2 | pages = 168–72 | date = April 2010 | pmid = 20346915 | doi = 10.1016/j.bbrc.2010.03.108 | pmc = 4410840 }} * {{cite journal | vauthors = Breuiller-Fouché M, Leroy MJ, Dubois O, Reinaud P, Chissey A, Qi H, Germain G, Fortier MA, Charpigny G | title = Differential expression of the enzymatic system controlling synthesis, metabolism, and transport of PGF2 alpha in human fetal membranes | journal = Biology of Reproduction | volume = 83 | issue = 1 | pages = 155–62 | date = July 2010 | pmid = 20357271 | doi = 10.1095/biolreprod.109.080390 | doi-access = free }} * {{cite journal | vauthors = Lu R, Kanai N, Bao Y, Schuster VL | title = Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT) | journal = The Journal of Clinical Investigation | volume = 98 | issue = 5 | pages = 1142–9 | date = September 1996 | pmid = 8787677 | pmc = 507536 | doi = 10.1172/JCI118897 }} * {{cite journal | vauthors = Lu R, Schuster VL | title = Molecular cloning of the gene for the human prostaglandin transporter hPGT: gene organization, promoter activity, and chromosomal localization | journal = Biochemical and Biophysical Research Communications | volume = 246 | issue = 3 | pages = 805–12 | date = May 1998 | pmid = 9618293 | doi = 10.1006/bbrc.1998.8715 }} * {{cite journal | vauthors = Topper JN, Cai J, Stavrakis G, Anderson KR, Woolf EA, Sampson BA, Schoen FJ, Falb D, Gimbrone MA | title = Human prostaglandin transporter gene (hPGT) is regulated by fluid mechanical stimuli in cultured endothelial cells and expressed in vascular endothelium in vivo | journal = Circulation | volume = 98 | issue = 22 | pages = 2396–403 | date = December 1998 | pmid = 9832484 | doi = 10.1161/01.CIR.98.22.2396 | doi-access = free }} {{refend}}

== External links == * {{PDBe-KB2|Q92959|Solute carrier organic anion transporter family member 2A1}}

Category:Solute carrier family