Mitochondrial 2-oxoglutarate/malate carrier protein

{{Short description|Mammalian protein found in Homo sapiens}} {{cs1 config|name-list-style=vanc}} {{Infobox_gene}} '''Mitochondrial 2-oxoglutarate/malate carrier protein''' is a protein that in humans is encoded by the ''SLC25A11'' gene.<ref name="pmid10072597">{{cite journal | vauthors = Piccininni S, Iacobazzi V, Lauria G, Rocchi M, Palmieri F | title = Assignment of the oxoglutarate carrier gene (SLC20A4) to human chromosome 17p13.3 | journal = Cytogenetics and Cell Genetics | volume = 83 | issue = 3–4 | pages = 256–257 | date = Mar 1999 | pmid = 10072597 | doi = 10.1159/000015198 | s2cid = 36221506 }}</ref><ref name="pmid1457818">{{cite journal | vauthors = Iacobazzi V, Palmieri F, Runswick MJ, Walker JE | title = Sequences of the human and bovine genes for the mitochondrial 2-oxoglutarate carrier | journal = DNA Sequence | volume = 3 | issue = 2 | pages = 79–88 | date = Jan 1993 | pmid = 1457818 | doi = 10.3109/10425179209034000 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=8402}}</ref> Inactivating mutations in this gene predispose to metastasic paraganglioma.<ref>{{cite journal | vauthors = Buffet A, Morin A, Castro-Vega LJ, Habarou F, Lussey-Lepoutre C, Letouzé E, Lefebvre H, Guilhem I, Haissaguerre M, Raingeard I, Padilla-Girola M, Tran T, Tchara L, Bertherat J, Amar L, Ottolenghi C, Burnichon N, Gimenez-Roqueplo AP, Favier J | display-authors = 6 | title = Germline Mutations in the Mitochondrial 2-Oxoglutarate/Malate Carrier <i>SLC25A11</i> Gene Confer a Predisposition to Metastatic Paragangliomas | journal = Cancer Research | volume = 78 | issue = 8 | pages = 1914–1922 | date = April 2018 | pmid = 29431636 | doi = 10.1158/0008-5472.CAN-17-2463 | doi-access = free }}</ref>

== See also == * Solute carrier family

== References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Bisaccia F, Zara V, Capobianco L, Iacobazzi V, Mazzeo M, Palmieri F | title = The formation of a disulfide cross-link between the two subunits demonstrates the dimeric structure of the mitochondrial oxoglutarate carrier | journal = Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology | volume = 1292 | issue = 2 | pages = 281–288 | date = February 1996 | pmid = 8597574 | doi = 10.1016/0167-4838(95)00215-4 }} * {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Analytical Biochemistry | volume = 236 | issue = 1 | pages = 107–113 | date = April 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }} * {{cite journal | vauthors = Bisaccia F, Capobianco L, Mazzeo M, Palmieri F | title = The mitochondrial oxoglutarate carrier protein contains a disulfide bridge between intramembranous cysteines 221 and 224 | journal = FEBS Letters | volume = 392 | issue = 1 | pages = 54–58 | date = August 1996 | pmid = 8769314 | doi = 10.1016/0014-5793(96)00784-3 | s2cid = 46276462 | doi-access = | bibcode = 1996FEBSL.392...54B }} * {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | display-authors = 6 | title = Large-scale concatenation cDNA sequencing | journal = Genome Research | volume = 7 | issue = 4 | pages = 353–358 | date = April 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }} * {{cite journal | vauthors = Palmisano A, Zara V, Hönlinger A, Vozza A, Dekker PJ, Pfanner N, Palmieri F | title = Targeting and assembly of the oxoglutarate carrier: general principles for biogenesis of carrier proteins of the mitochondrial inner membrane | journal = The Biochemical Journal | volume = 333 | issue = Pt 1 | pages = 151–158 | date = July 1998 | pmid = 9639574 | pmc = 1219567 | doi = 10.1042/bj3330151 }} * {{cite journal | vauthors = Coll O, Colell A, García-Ruiz C, Kaplowitz N, Fernández-Checa JC | title = Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion | journal = Hepatology | volume = 38 | issue = 3 | pages = 692–702 | date = September 2003 | pmid = 12939596 | doi = 10.1053/jhep.2003.50351 | hdl-access = free | s2cid = 2128549 | hdl = 10261/111821 }} * {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | display-authors = 6 | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–1178 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | s2cid = 4427026 | bibcode = 2005Natur.437.1173R }} * {{cite journal | vauthors = Kabe Y, Ohmori M, Shinouchi K, Tsuboi Y, Hirao S, Azuma M, Watanabe H, Okura I, Handa H | display-authors = 6 | title = Porphyrin accumulation in mitochondria is mediated by 2-oxoglutarate carrier | journal = The Journal of Biological Chemistry | volume = 281 | issue = 42 | pages = 31729–31735 | date = October 2006 | pmid = 16920706 | doi = 10.1074/jbc.M604729200 | doi-access = free }} {{refend}}

Category:Solute carrier family