{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''E3 ubiquitin-protein ligase SIAH2''' is an [[enzyme]] that in humans is encoded by the ''SIAH2'' [[gene]].<ref name="pmid9334332">{{cite journal | vauthors = Hu G, Zhang S, Vidal M, Baer JL, Xu T, Fearon ER | title = Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway | journal = Genes & Development | volume = 11 | issue = 20 | pages = 2701–14 | date = October 1997 | pmid = 9334332 | pmc = 316613 | doi = 10.1101/gad.11.20.2701 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SIAH2 seven in absentia homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=6478}}</ref>
== Function ==
This gene encodes a protein that is a member of the [[seven in absentia homolog]] (SIAH) family. The protein is an [[E3 ligase]] and is involved in [[ubiquitination]] and proteasome-mediated degradation of specific proteins. The activity of this [[ubiquitin ligase]] has been implicated in regulating cellular response to [[hypoxia (medical)|hypoxia]].<ref name="entrez" />
== Interactions ==
SIAH2 has been shown to [[Protein-protein interaction|interact]] with [[PEG10]],<ref name=pmid12810624>{{cite journal | vauthors = Okabe H, Satoh S, Furukawa Y, Kato T, Hasegawa S, Nakajima Y, Yamaoka Y, Nakamura Y | title = Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1 | journal = Cancer Research | volume = 63 | issue = 12 | pages = 3043–8 | date = June 2003 | pmid = 12810624 }}</ref> [[Synaptophysin]],<ref name=pmid11786535>{{cite journal | vauthors = Wheeler TC, Chin LS, Li Y, Roudabush FL, Li L | title = Regulation of synaptophysin degradation by mammalian homologues of seven in absentia | journal = The Journal of Biological Chemistry | volume = 277 | issue = 12 | pages = 10273–82 | date = March 2002 | pmid = 11786535 | doi = 10.1074/jbc.M107857200 | doi-access = free }}</ref> [[PEG3]]<ref name=pmid10681424>{{cite journal | vauthors = Relaix F, Wei XJ, Li W, Pan J, Lin Y, Bowtell DD, Sassoon DA, Wu X | title = Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 5 | pages = 2105–10 | date = February 2000 | pmid = 10681424 | pmc = 15761 | doi = 10.1073/pnas.040378897 | bibcode = 2000PNAS...97.2105R | doi-access = free }}</ref> and [[VAV1]].<ref name=pmid10207103>{{cite journal | vauthors = Germani A, Romero F, Houlard M, Camonis J, Gisselbrecht S, Fischer S, Varin-Blank N | title = hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways | journal = Molecular and Cellular Biology | volume = 19 | issue = 5 | pages = 3798–807 | date = May 1999 | pmid = 10207103 | pmc = 84217 | doi=10.1128/mcb.19.5.3798}}</ref>
== References == {{reflist}}
== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }} * {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }} * {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }} * {{cite journal | vauthors = Hu G, Chung YL, Glover T, Valentine V, Look AT, Fearon ER | title = Characterization of human homologs of the Drosophila seven in absentia (sina) gene | journal = Genomics | volume = 46 | issue = 1 | pages = 103–11 | date = November 1997 | pmid = 9403064 | doi = 10.1006/geno.1997.4997 | doi-access = free }} * {{cite journal | vauthors = Hu G, Fearon ER | title = Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins | journal = Molecular and Cellular Biology | volume = 19 | issue = 1 | pages = 724–32 | date = January 1999 | pmid = 9858595 | pmc = 83929 | doi = 10.1128/mcb.19.1.724}} * {{cite journal | vauthors = Germani A, Romero F, Houlard M, Camonis J, Gisselbrecht S, Fischer S, Varin-Blank N | title = hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways | journal = Molecular and Cellular Biology | volume = 19 | issue = 5 | pages = 3798–807 | date = May 1999 | pmid = 10207103 | pmc = 84217 | doi = 10.1128/mcb.19.5.3798}} * {{cite journal | vauthors = Relaix F, Wei XJ, Li W, Pan J, Lin Y, Bowtell DD, Sassoon DA, Wu X | title = Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 5 | pages = 2105–10 | date = February 2000 | pmid = 10681424 | pmc = 15761 | doi = 10.1073/pnas.040378897 | bibcode = 2000PNAS...97.2105R | doi-access = free }} * {{cite journal | vauthors = Joensuu T, Hämäläinen R, Lehesjoki AE, de la Chapelle A, Sankila EM | title = A sequence-ready map of the Usher syndrome type III critical region on chromosome 3q | journal = Genomics | volume = 63 | issue = 3 | pages = 409–16 | date = February 2000 | pmid = 10704288 | doi = 10.1006/geno.1999.6096 }} * {{cite journal | vauthors = Matsuzawa SI, Reed JC | title = Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses | journal = Molecular Cell | volume = 7 | issue = 5 | pages = 915–26 | date = May 2001 | pmid = 11389839 | doi = 10.1016/S1097-2765(01)00242-8 | doi-access = free }} * {{cite journal | vauthors = Boehm J, He Y, Greiner A, Staudt L, Wirth T | title = Regulation of BOB.1/OBF.1 stability by SIAH | journal = The EMBO Journal | volume = 20 | issue = 15 | pages = 4153–62 | date = August 2001 | pmid = 11483518 | pmc = 149152 | doi = 10.1093/emboj/20.15.4153 }} * {{cite journal | vauthors = Wheeler TC, Chin LS, Li Y, Roudabush FL, Li L | title = Regulation of synaptophysin degradation by mammalian homologues of seven in absentia | journal = The Journal of Biological Chemistry | volume = 277 | issue = 12 | pages = 10273–82 | date = March 2002 | pmid = 11786535 | doi = 10.1074/jbc.M107857200 | doi-access = free }} * {{cite journal | vauthors = Kutsenko AS, Gizatullin RZ, Al-Amin AN, Wang F, Kvasha SM, Podowski RM, Matushkin YG, Gyanchandani A, Muravenko OV, Levitsky VG, Kolchanov NA, Protopopov AI, Kashuba VI, Kisselev LL, Wasserman W, Wahlestedt C, Zabarovsky ER | title = NotI flanking sequences: a tool for gene discovery and verification of the human genome | journal = Nucleic Acids Research | volume = 30 | issue = 14 | pages = 3163–70 | date = July 2002 | pmid = 12136098 | pmc = 135748 | doi = 10.1093/nar/gkf428 }} * {{cite journal | vauthors = Habelhah H, Frew IJ, Laine A, Janes PW, Relaix F, Sassoon D, Bowtell DD, Ronai Z | title = Stress-induced decrease in TRAF2 stability is mediated by Siah2 | journal = The EMBO Journal | volume = 21 | issue = 21 | pages = 5756–65 | date = November 2002 | pmid = 12411493 | pmc = 131073 | doi = 10.1093/emboj/cdf576 }} * {{cite journal | vauthors = Okabe H, Satoh S, Furukawa Y, Kato T, Hasegawa S, Nakajima Y, Yamaoka Y, Nakamura Y | title = Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1 | journal = Cancer Research | volume = 63 | issue = 12 | pages = 3043–8 | date = June 2003 | pmid = 12810624 }} * {{cite journal | vauthors = Fanelli M, Fantozzi A, De Luca P, Caprodossi S, Matsuzawa S, Lazar MA, Pelicci PG, Minucci S | title = The coiled-coil domain is the structural determinant for mammalian homologues of Drosophila Sina-mediated degradation of promyelocytic leukemia protein and other tripartite motif proteins by the proteasome | journal = The Journal of Biological Chemistry | volume = 279 | issue = 7 | pages = 5374–9 | date = February 2004 | pmid = 14645235 | doi = 10.1074/jbc.M306407200 | doi-access = free }} * {{cite journal | vauthors = Germani A, Prabel A, Mourah S, Podgorniak MP, Di Carlo A, Ehrlich R, Gisselbrecht S, Varin-Blank N, Calvo F, Bruzzoni-Giovanelli H | title = SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway | journal = Oncogene | volume = 22 | issue = 55 | pages = 8845–51 | date = December 2003 | pmid = 14654780 | doi = 10.1038/sj.onc.1206994 | doi-access = free }} * {{cite journal | vauthors = Nakayama K, Frew IJ, Hagensen M, Skals M, Habelhah H, Bhoumik A, Kadoya T, Erdjument-Bromage H, Tempst P, Frappell PB, Bowtell DD, Ronai Z | title = Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia | journal = Cell | volume = 117 | issue = 7 | pages = 941–52 | date = June 2004 | pmid = 15210114 | doi = 10.1016/j.cell.2004.06.001 | s2cid = 1447980 | doi-access = free }} {{refend}}