SH3GL3

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Endophilin-A3''' is a protein that in humans is encoded by the ''SH3GL3'' gene.<ref name="pmid9169142">{{cite journal | vauthors = Giachino C, Lantelme E, Lanzetti L, Saccone S, Bella Valle G, Migone N | title = A novel SH3-containing human gene family preferentially expressed in the central nervous system | journal = Genomics | volume = 41 | issue = 3 | pages = 427–34 | date = July 1997 | pmid = 9169142 | doi = 10.1006/geno.1997.4645 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SH3GL3 SH3-domain GRB2-like 3| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=6457}}</ref>

== Interactions ==

SH3GL3 has been shown to interact with Huntingtin<ref name=pmid9809064>{{cite journal | vauthors = Sittler A, Wälter S, Wedemeyer N, Hasenbank R, Scherzinger E, Eickhoff H, Bates GP, Lehrach H, Wanker EE | title = SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates | journal = Mol. Cell | volume = 2 | issue = 4 | pages = 427–36 | date = October 1998 | pmid = 9809064 | doi = 10.1016/S1097-2765(00)80142-2 | doi-access = free }}</ref> and SH3KBP1.<ref name=pmid11894096>{{cite journal | vauthors = Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S | title = The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met | journal = Nature | volume = 416 | issue = 6877 | pages = 187–90 | date = March 2002 | pmid = 11894096 | doi = 10.1038/416187a | bibcode = 2002Natur.416..187P | s2cid = 4389099 }}</ref>

== References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = So CW, Caldas C, Liu MM, Chen SJ, Huang QH, Gu LJ, Sham MH, Wiedemann LM, Chan LC | title = EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 6 | pages = 2563–8 | year = 1997 | pmid = 9122235 | pmc = 20128 | doi = 10.1073/pnas.94.6.2563 | bibcode = 1997PNAS...94.2563S | doi-access = free }} * {{cite journal | vauthors = Ringstad N, Nemoto Y, De Camilli P | title = The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 16 | pages = 8569–74 | year = 1997 | pmid = 9238017 | pmc = 23017 | doi = 10.1073/pnas.94.16.8569 | bibcode = 1997PNAS...94.8569R | doi-access = free }} * {{cite journal | vauthors = Sittler A, Wälter S, Wedemeyer N, Hasenbank R, Scherzinger E, Eickhoff H, Bates GP, Lehrach H, Wanker EE | title = SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates. | journal = Mol. Cell | volume = 2 | issue = 4 | pages = 427–36 | year = 1998 | pmid = 9809064 | doi = 10.1016/S1097-2765(00)80142-2 | doi-access = free }} * {{cite journal | vauthors = Tang Y, Hu LA, Miller WE, Ringstad N, Hall RA, Pitcher JA, DeCamilli P, Lefkowitz RJ | title = Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 22 | pages = 12559–64 | year = 1999 | pmid = 10535961 | pmc = 22990 | doi = 10.1073/pnas.96.22.12559 | bibcode = 1999PNAS...9612559T | doi-access = free }} * {{cite journal | vauthors = Cestra G, Castagnoli L, Dente L, Minenkova O, Petrelli A, Migone N, Hoffmüller U, Schneider-Mergener J, Cesareni G | title = The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity. | journal = J. Biol. Chem. | volume = 274 | issue = 45 | pages = 32001–7 | year = 1999 | pmid = 10542231 | doi = 10.1074/jbc.274.45.32001 | doi-access = free }} * {{cite journal | vauthors = So CW, So CK, Cheung N, Chew SL, Sham MH, Chan LC | title = The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: implications for leukaemogenesis. | journal = Leukemia | volume = 14 | issue = 4 | pages = 594–601 | year = 2000 | pmid = 10764144 | doi = 10.1038/sj.leu.2401692 | doi-access = free }} * {{cite journal | vauthors = So CW, Sham MH, Chew SL, Cheung N, So CK, Chung SK, Caldas C, Wiedemann LM, Chan LC | title = Expression and protein-binding studies of the EEN gene family, new interacting partners for dynamin, synaptojanin and huntingtin proteins. | journal = Biochem. J. | volume = 348 | issue = 2 | pages = 447–58 | year = 2000 | pmid = 10816441 | pmc = 1221085 | doi = 10.1042/0264-6021:3480447 }} * {{cite journal | vauthors = Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S | title = The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met. | journal = Nature | volume = 416 | issue = 6877 | pages = 187–90 | year = 2002 | pmid = 11894096 | doi = 10.1038/416187a | bibcode = 2002Natur.416..187P | s2cid = 4389099 }} * {{cite journal | vauthors = Chatellard-Causse C, Blot B, Cristina N, Torch S, Missotten M, Sadoul R | title = Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization. | journal = J. Biol. Chem. | volume = 277 | issue = 32 | pages = 29108–15 | year = 2002 | pmid = 12034747 | doi = 10.1074/jbc.M204019200 | doi-access = free }} * {{cite journal | vauthors = Verdier F, Valovka T, Zhyvoloup A, Drobot LB, Buchman V, Waterfield M, Gout I | title = Ruk is ubiquitinated but not degraded by the proteasome. | journal = Eur. J. Biochem. | volume = 269 | issue = 14 | pages = 3402–8 | year = 2002 | pmid = 12135478 | doi = 10.1046/j.1432-1033.2002.03031.x | doi-access = free }} * {{cite journal | vauthors = Szymkiewicz I, Kowanetz K, Soubeyran P, Dinarina A, Lipkowitz S, Dikic I | title = CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases. | journal = J. Biol. Chem. | volume = 277 | issue = 42 | pages = 39666–72 | year = 2002 | pmid = 12177062 | doi = 10.1074/jbc.M205535200 | doi-access = free }} * {{cite journal | vauthors = Otsuki M, Itoh T, Takenawa T | title = Neural Wiskott-Aldrich syndrome protein is recruited to rafts and associates with endophilin A in response to epidermal growth factor. | journal = J. Biol. Chem. | volume = 278 | issue = 8 | pages = 6461–9 | year = 2003 | pmid = 12477732 | doi = 10.1074/jbc.M207433200 | doi-access = free }} * {{cite journal | vauthors = Yam JW, Jin DY, So CW, Chan LC | title = Identification and characterization of EBP, a novel EEN binding protein that inhibits Ras signaling and is recruited into the nucleus by the MLL-EEN fusion protein. | journal = Blood | volume = 103 | issue = 4 | pages = 1445–53 | year = 2004 | pmid = 14551139 | doi = 10.1182/blood-2003-07-2452 | hdl = 10722/48499 | doi-access = free | hdl-access = free }} * {{cite journal|author23-link=Bernhard Landwehrmeyer | vauthors = Goehler H, Lalowski M, Stelzl U, Waelter S, Stroedicke M, Worm U, Droege A, Lindenberg KS, Knoblich M, Haenig C, Herbst M, Suopanki J, Scherzinger E, Abraham C, Bauer B, Hasenbank R, Fritzsche A, Ludewig AH, Büssow K, Buessow K, Coleman SH, Gutekunst CA, Landwehrmeyer BG, Lehrach H, Wanker EE | title = A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. | journal = Mol. Cell | volume = 15 | issue = 6 | pages = 853–65 | year = 2004 | pmid = 15383276 | doi = 10.1016/j.molcel.2004.09.016 | doi-access = free }} * {{cite journal | vauthors = Trevaskis J, Walder K, Foletta V, Kerr-Bayles L, McMillan J, Cooper A, Lee S, Bolton K, Prior M, Fahey R, Whitecross K, Morton GJ, Schwartz MW, Collier GR | title = Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance. | journal = Endocrinology | volume = 146 | issue = 9 | pages = 3757–64 | year = 2005 | pmid = 15919751 | doi = 10.1210/en.2005-0282 | doi-access = free | hdl = 10536/DRO/DU:30009269 | hdl-access = free }} * {{cite journal | vauthors = Ralser M, Nonhoff U, Albrecht M, Lengauer T, Wanker EE, Lehrach H, Krobitsch S | title = Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways. | journal = Hum. Mol. Genet. | volume = 14 | issue = 19 | pages = 2893–909 | year = 2005 | pmid = 16115810 | doi = 10.1093/hmg/ddi321 | doi-access = free | hdl = 11858/00-001M-0000-0010-85BB-5 | hdl-access = free }} * {{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome. | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | year = 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 | hdl = 11858/00-001M-0000-0010-8592-0 | s2cid = 8235923 | hdl-access = free }} * {{cite journal | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | year = 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 | doi-access = free }} {{refend}}