{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}} '''SH3 domain-binding protein 4''' is a protein that in humans is encoded by the ''SH3BP4'' gene.<ref name="pmid10644451">{{cite journal | vauthors = Dunlevy JR, Berryhill BL, Vergnes JP, SundarRaj N, Hassell JR | title = Cloning, chromosomal localization, and characterization of cDNA from a novel gene, SH3BP4, expressed by human corneal fibroblasts | journal = Genomics | volume = 62 | issue = 3 | pages = 519–24 |date=Mar 2000 | pmid = 10644451 | doi = 10.1006/geno.1999.5994 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SH3BP4 SH3-domain binding protein 4| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=23677}}</ref>
This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor.<ref name="entrez" />
==References== {{reflist}}
==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Wong WT, Schumacher C, Salcini AE, etal |title=A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 21 |pages= 9530–4 |year= 1995 |pmid= 7568168 |doi= 10.1073/pnas.92.21.9530| pmc=40835 |bibcode=1995PNAS...92.9530W |doi-access=free }} *{{cite journal |vauthors=Salcini AE, Confalonieri S, Doria M, etal |title=Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. |journal=Genes Dev. |volume=11 |issue= 17 |pages= 2239–49 |year= 1997 |pmid= 9303539 |doi= 10.1101/gad.11.17.2239| pmc=275390 }} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Jin J, Smith FD, Stark C, etal |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 |s2cid=2371325 |doi-access=free }} *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} *{{cite journal | vauthors=Khanobdee K, Kolberg JB, Dunlevy JR |title=Nuclear and plasma membrane localization of SH3BP4 in retinal pigment epithelial cells. |journal=Mol. Vis. |volume=10 |pages= 933–42 |year= 2005 |pmid= 15616480 }} *{{cite journal |vauthors=Benzinger A, Muster N, Koch HB, etal |title=Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. |journal=Mol. Cell. Proteomics |volume=4 |issue= 6 |pages= 785–95 |year= 2005 |pmid= 15778465 |doi= 10.1074/mcp.M500021-MCP200 |doi-access= free }} *{{cite journal |vauthors=Hillier LW, Graves TA, Fulton RS, etal |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |bibcode=2005Natur.434..724H |doi-access= free }} *{{cite journal |vauthors=Tosoni D, Puri C, Confalonieri S, etal |title=TTP specifically regulates the internalization of the transferrin receptor. |journal=Cell |volume=123 |issue= 5 |pages= 875–88 |year= 2006 |pmid= 16325581 |doi= 10.1016/j.cell.2005.10.021 |s2cid=5809800 |doi-access=free }} *{{cite journal |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |s2cid=14294292 }} *{{cite journal |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }} {{refend}}
{{gene-2-stub}}