SGSM2

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Small G protein signaling modulator 2''' is a protein that in humans is encoded by the ''SGSM2'' gene.<ref>{{cite journal |title=Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway.|first=H |last=Yang|journal=Genomics|year=2007|volume=90|issue=2|pages=249–260|pmid=17509819|doi=10.1016/j.ygeno.2007.03.013|display-authors=etal|doi-access=free}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: small G protein signaling modulator 2| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=9905| access-date = }}</ref>

==Clinical relevance== In a recent genome-wide association study, this gene has been associated with fasting glucose traits, type 2 diabetes and obesity.<ref name=pmid21873549>{{cite journal|last=Strawbridge|first=RJ|title=Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes.|journal=Diabetes|date=2011-08-26|pmid=21873549|doi=10.2337/db11-0415|pmc=3178302|volume=60|issue=10|pages=2624–34|display-authors=etal|url=https://archive-ouverte.unige.ch/unige:32202/ATTACHMENT01}}</ref>

==References== {{reflist}}

==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Stelzl U, Worm U, Lalowski M, etal |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 |doi-access= free |hdl= 11858/00-001M-0000-0010-8592-0 |hdl-access= free }} *{{cite journal |vauthors=Vasan RS, Glazer NL, Felix JF, etal |title=Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. |journal=JAMA |volume=302 |issue= 2 |pages= 168–78 |year= 2009 |pmid= 19584346 |doi= 10.1001/jama.2009.978-a |pmc=2975567}} *{{cite journal |vauthors=Ishikawa K, Nagase T, Nakajima D, etal |title=Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 5 |pages= 307–13 |year= 1997 |pmid= 9455477 |doi= 10.1093/dnares/4.5.307|doi-access=free }} *{{cite journal |author1=Yang H |author2=Sasaki T |author3=Minoshima S |author4=Shimizu N |title=Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway. |journal=Genomics |volume=90 |issue= 2 |pages= 249–60 |year= 2007 |pmid= 17509819 |doi= 10.1016/j.ygeno.2007.03.013 |doi-access=free }} *{{cite journal |author1=Ishibashi K |author2=Kanno E |author3=Itoh T |author4=Fukuda M |title=Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. |journal=Genes Cells |volume=14 |issue= 1 |pages= 41–52 |year= 2009 |pmid= 19077034 |doi= 10.1111/j.1365-2443.2008.01251.x |doi-access=free }} {{refend}}

Category:Human proteins