SGPL1

{{Short description|Enzyme}} {{Infobox_gene}} '''Sphingosine-1-phosphate lyase 1''' is an enzyme that, in humans, is encoded by the ''SGPL1'' gene.<ref name="pmid9464245">{{cite journal | vauthors = Zhou J, Saba JD | title = Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast | journal = Biochem Biophys Res Commun | volume = 242 | issue = 3 | pages = 502–7 |date=Mar 1998 | pmid = 9464245 | doi = 10.1006/bbrc.1997.7993 }}</ref><ref name="pmid17090686">{{cite journal | vauthors = Oskouian B, Sooriyakumaran P, Borowsky AD, Crans A, Dillard-Telm L, Tam YY, Bandhuvula P, Saba JD | title = Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer | journal = Proc Natl Acad Sci U S A | volume = 103 | issue = 46 | pages = 17384–9 |date=Nov 2006 | pmid = 17090686 | pmc = 1859938 | doi = 10.1073/pnas.0600050103 | bibcode = 2006PNAS..10317384O | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SGPL1 sphingosine-1-phosphate lyase 1| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=8879}}</ref>

==Pathology== A mutation in the gene can lead to sphingosine phosphate lyase insufficiency syndrome, which can cause steroid-resistant nephrotic syndrome with multisystemic manifestations, as such as ichthyosis, acanthosis, adrenal insufficiency, immunodeficiency, and neurologic defects.<ref name="pmid35904228">{{cite journal | vauthors = Maharaj A, Kwong R, Williams J, etal | title = A retrospective analysis of endocrine disease in sphingosine-1-phosphate lyase insufficiency: case series and literature review | journal = Endocr Connect |date=Jul 2022 | pmid = 35904228 | doi = 10.1530/EC-22-0250 | pmc = 9346324 }}</ref><ref name="pmid28165339">{{cite journal | vauthors = Lovric S, Goncalves S, Gee HY, etal | title = Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency | journal = J Clin Invest |date=Mar 2017 | pmid = 28165339 | doi = 10.1172/JCI89626 | hdl = 2078.1/204417 | hdl-access = free | pmc = 5330730 }}</ref>

==References== {{reflist}}

==Further reading== {{refbegin | 2}} *{{cite journal | vauthors=Van Veldhoven PP, Mannaerts GP |title=Subcellular localization and membrane topology of sphingosine-1-phosphate lyase in rat liver. |journal=J. Biol. Chem. |volume=266 |issue= 19 |pages= 12502–7 |year= 1991 |doi=10.1016/S0021-9258(18)98927-1 |pmid= 2061324 |doi-access=free }} *{{cite journal |vauthors=Nagase T, Ishikawa K, Kikuno R, etal |title=Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 5 |pages= 337–45 |year= 2000 |pmid= 10574462 |doi=10.1093/dnares/6.5.337 |doi-access=free }} *{{cite journal |vauthors=Van Veldhoven PP, Gijsbers S, Mannaerts GP, etal |title=Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22(1). |journal=Biochim. Biophys. Acta |volume=1487 |issue= 2–3 |pages= 128–34 |year= 2000 |pmid= 11018465 |doi= 10.1016/s1388-1981(00)00079-2}} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Reiss U, Oskouian B, Zhou J, etal |title=Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis. |journal=J. Biol. Chem. |volume=279 |issue= 2 |pages= 1281–90 |year= 2004 |pmid= 14570870 |doi= 10.1074/jbc.M309646200 |doi-access=free }} *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }} *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} *{{cite journal | vauthors=Zhan X, Desiderio DM |title=Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. |journal=Anal. Biochem. |volume=354 |issue= 2 |pages= 279–89 |year= 2006 |pmid= 16777052 |doi= 10.1016/j.ab.2006.05.024 }} {{refend}}