{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Shugoshin 2''' '''(Shugoshin-2)''', also known as '''Shugoshin-like 2''', is a protein which in humans is encoded by the ''SGO2'' gene.<ref name="UniProt">{{cite web |title=UniProt |url=https://www.uniprot.org/uniprotkb/Q562F6/entry#names_and_taxonomy |website=www.uniprot.org |access-date=6 November 2022}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SGOL2 shugoshin-like 2 | url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=151246}}</ref><ref name="pmid14730319">{{cite journal |author1=Kitajima TS |author2=Kawashima SA |author3=Watanabe Y | title = The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis | journal = Nature | volume = 427 | issue = 6974 | pages = 510–7 |date=February 2004 | pmid = 14730319 | doi = 10.1038/nature02312 |bibcode=2004Natur.427..510K |s2cid=4400426 }}</ref>

== Function == Shugoshin-2 is one of the two mammalian orthologs of the Shugoshin/Mei-S322 family of proteins that regulate sister chromatid cohesion by protecting the integrity of a multiprotein complex named cohesin.<ref name="pmid16541025">{{cite journal |author1=Kitajima TS |author2=Sakuno T |author3=Ishiguro K |author4=Iemura S |author5=Natsume T |author6=Kawashima SA |author7=Watanabe Y | title = Shugoshin collaborates with protein phosphatase 2A to protect cohesin | journal = Nature | volume = 441 | issue = 7089 | pages = 46–52 |date=May 2006 | pmid = 16541025 | doi = 10.1038/nature04663 |bibcode=2006Natur.441...46K |s2cid=4425074 }}</ref> This protective system is essential for faithful chromosome segregation during mitosis and meiosis, which is the physical basis of Mendelian inheritance.

==References== {{reflist}}

==Further reading== {{refbegin | 2}} *{{cite journal |author1=Hartley JL |author2=Temple GF |author3=Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }} *{{cite journal |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 }} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }} *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} *{{cite journal |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 }} *{{cite journal |vauthors=Hillier LW, Graves TA, Fulton RS, etal |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4 |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |bibcode=2005Natur.434..724H |doi-access= free }} *{{cite journal |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 }} *{{cite journal |vauthors=Kitajima TS, Sakuno T, Ishiguro K, etal |title=Shugoshin collaborates with protein phosphatase 2A to protect cohesin |journal=Nature |volume=441 |issue= 7089 |pages= 46–52 |year= 2006 |pmid= 16541025 |doi= 10.1038/nature04663 |bibcode=2006Natur.441...46K |s2cid=4425074 }} *{{cite journal |vauthors=Nousiainen M, Silljé HH, Sauer G, etal |title=Phosphoproteome analysis of the human mitotic spindle |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 | pmc=1459365 |bibcode=2006PNAS..103.5391N |doi-access=free }} *{{cite journal |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|article-number= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }} {{refend}}

Category:Genes mutated in mice