'''SCE''' is an abbreviation with multiple meanings:

==Science== * Short-channel effect, a secondary effect describing the reduction in threshold voltage Vth in MOSFETs with non-uniformly doped channel regions as the gate length increases * Saturated calomel electrode, a commonly used reference electrode used in pH measurement and general aqueous electrochemistry * Subcutaneous emphysema, air trapped in the subcutaneous layer of the tissues * Sister chromatid exchange, the exchange of genetic material between two identical sister chromatids * Standard Canadian English, the variety of Canadian English spoken particularly across Ontario and Western Canada.

==Education== * Hong Kong School Certificate Examination, a standardized examination from 1974 to 2011 * Scottish Certificate of Education was a certificate of the Scottish Secondary Education system incorporating Standard and Higher Grades * Sami Shamoon College of Engineering, a STEM-oriented college in southern Israel * School of Continuing Education, an adult continuing education school in Orange County, California * School of Continuing Education, Hong Kong Baptist University, one of the seven schools of the Hong Kong Baptist University * Service Children's Education, a support agency acting as a Local Education Authority for British service schools overseas

==Computing== * System Center Essentials, a performance and event monitoring product from Microsoft * Service Creation Environment, a development environment used to create the services present in an Intelligent Network * Scalable Cluster Environment, a software project for cluster computing *Sony Interactive Entertainment, formerly named Sony Computer Entertainment

==Organisations== *Southern California Edison, investor-owned electric utility in California, USA. *China SCE Property, a property developer in Fujian, China *Sony Computer Entertainment, a former video game division within Sony Corporation *Singapore Combat Engineers, one of the combat arms of the Singapore Armed Forces *Saudi Council of Engineers *Societas cooperativa Europaea (Latin for ''European Cooperative Society'', a European legal society for companies or individuals from different EU states

==Other== * Starfleet Corps of Engineers, a series of books from the fictional ''Star Trek'' universe * State College Regional Airport, an airport in State College, Pennsylvania with IATA code "SCE" * Swedish Cyprus Expedition, a project to systematically investigate the archaeology of the early history of Cyprus.

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