'''S28''' may refer to:
{{TOC right}} == Aviation == * Blériot-SPAD S.28, a French long-distance biplane * International Peace Garden Airport in Rolette County, North Dakota * Letov Š-28, a Czechoslovak reconnaissance biplane * Sikorsky S-28, a proposed French biplane bomber
== Rail == * S28 (Rhine-Ruhr S-Bahn), a service in Germany * S28, an Aargau S-Bahn service in Switzerland
== Roads == * County Route S28 (California) * New Jersey Route 18, partially designated S28 until 1953 * Northern Airport Expressway, China
== Science == * 40S ribosomal protein S28 * British NVC community S28, a swamps and tall-herb fens community in the British National Vegetation Classification system * S28: After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer), a safety phrase * Sulfur-28, an isotope of sulfur
== Other uses == * {{HMS|Vanguard|S28}}, a submarine of the Royal Navy * Mena Station, in Rankoshi, Isoya District, Hokkaido, Japan * SREC (file format), an ASCII encoding format for binary data * {{USS|S-28|SS-133}}, a submarine of the United States Navy
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