{{short description|Canadian geneticist}} {{Infobox scientist/Wikidata | fetchwikidata=ALL | onlysourced=yes | name = Rob Klose |image =File:Rob 3.png | caption = Rob Klose in 2026 | birth_name = | birth_date = {{birth date and age|1977|12|28}} | field = CpG islands<br>ChromatinGene regulation<ref name=gs/> |alma_mater = {{Plainlist| * University of Waterloo (BSc) * University of Edinburgh (PhD)}} | module = {{Infobox scientist | embed = yes | known_for = Research on chromatin-based and epigenetic mechanisms | thesis_title = Biochemical analysis of MeCP2 | thesis_url = http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.653493 | thesis_year = 2005 | doctoral_advisor =Adrian Bird | doctoral_students = }}}} '''Rob Klose''' (born December 28, 1977) is a Canadian researcher and Professor of Genetics at the Department of Biochemistry, University of Oxford.<ref name=epmc>{{EuropePMC|ORCID=0000-0002-8726-7888}}</ref><ref name=gs>{{Google scholar id}}</ref><ref name="Professor Rob Klose">{{cite web|last1=Klose|first1=Rob|title=Professor Rob Klose|url=https://www.bioch.ox.ac.uk/research/klose|website=Department of Biochemistry, University of Oxford|accessdate=6 November 2017}}</ref> His research investigates how chromatin-based and epigenetic mechanisms contribute to the ways in which gene expression is regulated.<ref>{{cite journal|last1=Klose|first1=Rob|title=CpG islands recruit a histone H3 lysine 36 demethylase|journal=Mol. Cell|date=2010|volume=38|issue=2|pages=179–90|doi=10.1016/j.molcel.2010.04.009|pmid=20417597|pmc=3098377}}</ref><ref>{{cite journal|last1=Klose|first1=Rob|title=ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection|journal=Biochem Soc Trans|date=2013|volume=41|issue=3|pages=727–40|doi=10.1042/BST20130028|pmid=23697932|pmc=3685328}}</ref><ref>{{cite journal|last1=Klose|first1=Rob|title=Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation|journal=Cell|date=2014|volume=157|issue=6|pages=1445–59|doi=10.1016/j.cell.2014.05.004|pmid=24856970|pmc=4048464}}</ref>
==Education== Klose was an undergraduate student at the University of Waterloo in Ontario, Canada, where he graduated with Dean's Honors in Biology. He was a postgraduate student supervised by Adrian Bird at the Wellcome Centre for Cell Biology at the University of Edinburgh, Scotland, where he studied the methyl CpG binding protein MeCP2, part of the DNA methylation system, which is associated with Rett syndrome.<ref>{{cite journal|last1=Klose|first1=Rob|title=DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG|journal=Mol. Cell|date=2005|volume=19|issue=5|pages=667–78|doi=10.1016/j.molcel.2005.07.021|pmid=16137622|doi-access=free}}</ref> He obtained his Doctor of Philosophy in 2005.<ref name=rphd>{{cite thesis|degree=PhD|last1=Klose|first1=Rob|date=2005|title=Biochemical analysis of MeCP2|id={{EThOS|uk.bl.ethos.653493}}|website=ed.ac.uk|publisher=University of Edinburgh|hdl=1842/10997|url=https://www.era.lib.ed.ac.uk/handle/1842/10997}}</ref>
==Career and research== Klose spent two years as a postdoctoral researcher in the laboratory of Yi Zhang, who was based at the University of North Carolina at Chapel Hill, identifying a novel family of histone lysine demethylase enzymes.<ref>{{cite journal|last1=Klose|first1=Rob|title=The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36|journal=Nature|date=2006|volume=442|issue=7100|pages=312–6|doi=10.1038/nature04853|pmid=16732292|bibcode=2006Natur.442..312K|s2cid=4399312}}</ref><ref>{{cite journal|last1=Klose|first1=Rob|title=The retinoblastoma binding protein RBP2 is an H3K4 demethylase|journal=Cell|date=2007|volume=128|issue=5|pages=889–900|doi=10.1016/j.cell.2007.02.013|pmid=17320163|doi-access=free}}</ref><ref>{{cite journal|last1=Klose|first1=Rob|title=Regulation of histone methylation by demethylimination and demethylation|journal=Nat Rev Mol Cell Biol|date=2007|volume=8|issue=4|pages=307–18|doi=10.1038/nrm2143|pmid=17342184|s2cid=2616900}} {{closed access}}</ref> He then moved to the University of Oxford where, in 2008, he established himself as a Principal Investigator at the Department of Biochemistry at Oxford supported by a Wellcome Trust career development fellowship. Five years after this, he secured a Wellcome Trust senior research fellowship. Since then, he has been a Monsanto senior research fellow, a post associated with Exeter College, Oxford, and in 2014 was appointed as professor of cell and molecular biology. In 2017 he was appointed Professor of Genetics, University of Oxford, a chair held at the department of biochemistry and associated with a fellowship at Keble College, Oxford.
Klose's work throughout his career has sought to explain how, during development, cell types with the same DNA use chromatin-based and epigenetic mechanisms to restrict gene expression to the correct complement of genes in a stable and heritable way. In particular, he has focused on understanding how DNA encoded regulatory elements in vertebrates, called CpG islands, help to achieve appropriately controlled gene usage.
===Awards and honours=== Klose was awarded a European Molecular Biology Organization (EMBO) young investigator programme fellowship in 2010<ref>{{cite web|title=Twenty-one group leaders join network of EMBO Young Investigators|url=http://www.embo.org/news/press-releases/2010/twenty-one-group-leaders-join-network-of-embo-young-investigators|website=EMBO Press release 2010|accessdate=7 November 2017}}</ref> and was awarded a Lister Institute of Preventive Medicine Research prize in 2011.<ref>{{cite web|title=Lister Institute Current Prize Fellows|url=http://paisieres.co.uk/fellows/current-prize-fellows/|website=Lister Institute|accessdate=7 November 2017}}</ref> In recognition of his achievements as an early career stage scientist, he was awarded the Francis Crick Lecture by the Royal Society in 2015.<ref>{{cite web|title=Gene regulation and the epigenome, Prize lecture on 2 December 2015|url=https://royalsociety.org/science-events-and-lectures/2015/12/francis-crick-lecture/|website=Royal Society|accessdate=7 November 2017}}</ref> He was elected EMBO Member in 2021<ref name=membo>{{Cite web|url=https://people.embo.org/profile/robert-j-klose|title = Find people in the EMBO Communities}}</ref> and elected a Fellow of the Royal Society in 2026.<ref>{{Cite web |date=2026-05-27|title=Exceptional scientists elected as Fellows of the Royal Society|url=https://royalsociety.org/news/2026/05/new-fellows-announcement-2026/|access-date=2026-05-31|website=Royal Society|language=en}}</ref>
== References == {{reflist}}
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{{DEFAULTSORT:Klose, Rob}} Category:Canadian geneticists Category:Living people Category:1977 births Category:Alumni of the University of Edinburgh Category:University of Waterloo alumni Category:Professors of Genetics (University of Oxford)