RRAS2

{{cs1 config|name-list-style=vanc}} {{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Ras-related protein R-Ras2''' is a protein that in humans is encoded by the ''RRAS2'' gene.<ref name="pmid2108320">{{cite journal |vauthors=Drivas GT, Shih A, Coutavas E, Rush MG, D'Eustachio P | title = Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line | journal = Mol Cell Biol | volume = 10 | issue = 4 | pages = 1793–8 |date=May 1990 | pmid = 2108320 | pmc = 362288 | doi = 10.1128/mcb.10.4.1793}}</ref><ref name="pmid8052619">{{cite journal |vauthors=Chan AM, Miki T, Meyers KA, Aaronson SA | title = A human oncogene of the RAS superfamily unmasked by expression cDNA cloning | journal = Proc Natl Acad Sci U S A | volume = 91 | issue = 16 | pages = 7558–62 |date=September 1994 | pmid = 8052619 | pmc = 44441 | doi =10.1073/pnas.91.16.7558 | bibcode =1994PNAS...91.7558C | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RRAS2 related RAS viral (r-ras) oncogene homolog 2| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=22800| access-date = }}</ref>

==Interactions== RRAS2 has been shown to interact with C-Raf.<ref name=pmid10783161>{{cite journal |last=Li |first=W |author2=Han M |author3=Guan K L |date=April 2000 |title=The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf |journal=Genes Dev. |volume=14 |issue=8 |pages=895–900 |location = UNITED STATES|doi=10.1101/gad.14.8.895 | issn = 0890-9369| pmid = 10783161 |pmc=316541 }}</ref><ref name=pmid10557073>{{cite journal |last=Movilla |first=N |author2=Crespo P |author3=Bustelo X R |date=October 1999 |title=Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins |journal=Oncogene |volume=18 |issue=43 |pages=5860–9 |location = ENGLAND| issn = 0950-9232| pmid = 10557073 |doi = 10.1038/sj.onc.1202968 |s2cid=31576945 |doi-access= }}</ref>

==References== {{reflist}}

==Further reading== {{refbegin | 2}} *{{cite journal |vauthors=Ehrhardt A, Ehrhardt GR, Guo X, Schrader JW |title=Ras and relatives--job sharing and networking keep an old family together. |journal=Exp. Hematol. |volume=30 |issue= 10 |pages= 1089–106 |year= 2002 |pmid= 12384139 |doi=10.1016/S0301-472X(02)00904-9 |doi-access=free }} *{{cite journal |vauthors=Rosário M, Paterson HF, Marshall CJ |title=Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells. |journal=EMBO J. |volume=18 |issue= 5 |pages= 1270–9 |year= 1999 |pmid= 10064593 |doi= 10.1093/emboj/18.5.1270 | pmc=1171217 }} *{{cite journal |vauthors=Linnemann T, Geyer M, Jaitner BK, etal |title=Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily. |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 13556–62 |year= 1999 |pmid= 10224125 |doi=10.1074/jbc.274.19.13556 |doi-access=free }} *{{cite journal |vauthors=Ehrhardt GR, Leslie KB, Lee F, etal |title=M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line. |journal=Blood |volume=94 |issue= 7 |pages= 2433–44 |year= 1999 |pmid= 10498616 |doi= 10.1182/blood.V94.7.2433.419k31_2433_2444|s2cid=40024826 }} *{{cite journal |vauthors=Movilla N, Crespo P, Bustelo XR |title=Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins. |journal=Oncogene |volume=18 |issue= 43 |pages= 5860–9 |year= 1999 |pmid= 10557073 |doi= 10.1038/sj.onc.1202968 |s2cid=31576945 |doi-access= }} *{{cite journal |vauthors=Ohba Y, Mochizuki N, Yamashita S, etal |title=Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3. |journal=J. Biol. Chem. |volume=275 |issue= 26 |pages= 20020–6 |year= 2000 |pmid= 10777492 |doi= 10.1074/jbc.M000981200 |doi-access= free }} *{{cite journal |vauthors=Figueroa C, Taylor J, Vojtek AB |title=Prenylated Rab acceptor protein is a receptor for prenylated small GTPases. |journal=J. Biol. Chem. |volume=276 |issue= 30 |pages= 28219–25 |year= 2001 |pmid= 11335720 |doi= 10.1074/jbc.M101763200 |doi-access= free }} *{{cite journal |vauthors=Murphy GA, Graham SM, Morita S, etal |title=Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation. |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 9966–75 |year= 2002 |pmid= 11788587 |doi= 10.1074/jbc.M109059200 |doi-access= free }} *{{cite journal |vauthors=Rong R, He Q, Liu Y, etal |title=TC21 mediates transformation and cell survival via activation of phosphatidylinositol 3-kinase/Akt and NF-kappaB signaling pathway. |journal=Oncogene |volume=21 |issue= 7 |pages= 1062–70 |year= 2002 |pmid= 11850823 |doi= 10.1038/sj.onc.1205154 |s2cid=21196767 |doi-access=free }} *{{cite journal |vauthors=Ortiz-Vega S, Khokhlatchev A, Nedwidek M, etal |title=The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1. |journal=Oncogene |volume=21 |issue= 9 |pages= 1381–90 |year= 2002 |pmid= 11857081 |doi= 10.1038/sj.onc.1205192 |s2cid=240243 |doi-access= }} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Yuryev A, Wennogle LP |title=Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis. |journal=Genomics |volume=81 |issue= 2 |pages= 112–25 |year= 2003 |pmid= 12620389 |doi=10.1016/S0888-7543(02)00008-3 }} *{{cite journal |vauthors=Mitin NY, Ramocki MB, Zullo AJ, etal |title=Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization. |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 22353–61 |year= 2004 |pmid= 15031288 |doi= 10.1074/jbc.M312867200 |doi-access= free }} *{{cite journal |vauthors=Kho Y, Kim SC, Jiang C, etal |title=A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 34 |pages= 12479–84 |year= 2004 |pmid= 15308774 |doi= 10.1073/pnas.0403413101 | pmc=515085 |bibcode=2004PNAS..10112479K |doi-access=free }} *{{cite journal |vauthors=Suzuki Y, Yamashita R, Shirota M, etal |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 | pmc=515316 }} *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} *{{cite journal |vauthors=Barrios-Rodiles M, Brown KR, Ozdamar B, etal |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 |bibcode=2005Sci...307.1621B |s2cid=39457788 }} {{refend}} {{PDB Gallery|geneid=22800}}