REEP2

{{short description|Protein-coding gene in humans}} {{Infobox_gene}} '''Receptor expression-enhancing protein 2''' is a protein that in humans is encoded by the ''REEP2'' gene.<ref>{{Cite journal|last1=Clark|first1=Adrian J.L.|last2=Metherell|first2=Louise A.|last3=Cheetham|first3=Michael E.|last4=Huebner|first4=Angela|title=Inherited ACTH insensitivity illuminates the mechanisms of ACTH action|journal=Trends in Endocrinology & Metabolism|volume=16|issue=10|pages=451–457|doi=10.1016/j.tem.2005.10.006|pmid=16271481|year=2005|s2cid=27450434}}</ref><ref>{{Cite journal|last1=Saito|first1=Harumi|last2=Kubota|first2=Momoka|last3=Roberts|first3=Richard W.|last4=Chi|first4=Qiuyi|last5=Matsunami|first5=Hiroaki|title=RTP Family Members Induce Functional Expression of Mammalian Odorant Receptors|journal=Cell|volume=119|issue=5|pages=679–691|doi=10.1016/j.cell.2004.11.021|year=2004|pmid=15550249|s2cid=13555927|doi-access=free}}</ref>

== Function == The protein encoded by REEP2 belongs to a family of proteins with receptor enhancing expression capabilities, including possible enhancement of G protein-coupled receptors.<ref>{{Cite journal|last1=Björk|first1=Susann|last2=Hurt|first2=Carl M.|last3=Ho|first3=Vincent K.|last4=Angelotti|first4=Timothy|date=2013-12-17|title=Correction: REEPs Are Membrane Shaping Adapter Proteins That Modulate Specific G Protein-Coupled Receptor Trafficking by Affecting ER Cargo Capacity|journal=PLOS ONE|volume=8|issue=12|pages=10.1371/annotation/6f86410c-63c3-4fcd-b1cb-9fd8d2ea95d0|doi=10.1371/annotation/6f86410c-63c3-4fcd-b1cb-9fd8d2ea95d0|issn=1932-6203|pmc=3867549 |doi-access=free }}</ref> The REEP2 protein shows a restricted mode of expression in human tissues.<ref>{{Cite journal|last1=Uhlén|first1=Mathias|last2=Fagerberg|first2=Linn|last3=Hallström|first3=Björn M.|last4=Lindskog|first4=Cecilia|last5=Oksvold|first5=Per|last6=Mardinoglu|first6=Adil|last7=Sivertsson|first7=Åsa|last8=Kampf|first8=Caroline|last9=Sjöstedt|first9=Evelina|date=2015-01-23|title=Tissue-based map of the human proteome|journal=Science|language=en|volume=347|issue=6220|article-number=1260419|doi=10.1126/science.1260419|issn=0036-8075|pmid=25613900|s2cid=802377}}</ref>

== Clinical significance == REEP2 mutations have been reported in families with hereditary spastic paraplegia.<ref>{{Cite journal|last1=Esteves|first1=Typhaine|last2=Durr|first2=Alexandra|last3=Mundwiller|first3=Emeline|last4=Loureiro|first4=José L.|last5=Boutry|first5=Maxime|last6=Gonzalez|first6=Michael A.|last7=Gauthier|first7=Julie|last8=El-Hachimi|first8=Khalid H.|last9=Depienne|first9=Christel|title=Loss of Association of REEP2 with Membranes Leads to Hereditary Spastic Paraplegia|journal=The American Journal of Human Genetics|volume=94|issue=2|pages=268–277|doi=10.1016/j.ajhg.2013.12.005|pmid=24388663|pmc=3928657|year=2014}}</ref>

== References == {{reflist}}

== Further reading == {{refbegin | 2}} * {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }} * {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Analytical Biochemistry | volume = 236 | issue = 1 | pages = 107–13 | date = April 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }} * {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Research | volume = 7 | issue = 4 | pages = 353–8 | date = April 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }} * {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }} * {{cite journal | vauthors = Lai F, Godley LA, Joslin J, Fernald AA, Liu J, Espinosa R, Zhao N, Pamintuan L, Till BG, Larson RA, Qian Z, Le Beau MM | title = Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q) | journal = Genomics | volume = 71 | issue = 2 | pages = 235–45 | date = January 2001 | pmid = 11161817 | doi = 10.1006/geno.2000.6414 }} {{refend}}