{{Short description|Mammalian protein found in Homo sapiens}} {{about|the protein|the Italian television channel|Rai 1}} {{cs1 config|name-list-style=vanc|display-authors=6}} {{infobox gene}}
'''Retinoic acid-induced protein 1''' is a transcription factor that in humans is encoded by the '''RAI1''' gene. Mutations or copy number alterations affecting this gene are associated with neurodevelopmental disorders. Deletions of RAI1 are a primary cause of Smith–Magenis syndrome,<ref>{{cite journal | vauthors = Hamiel U, Kurolap A, Gadot CC, Mory A, Shira AB, Feldman HB, Marom D | title = Deletion of <i>RAI1</i> noncoding exons 1-2 causes Smith-Magenis syndrome | journal = Journal of Genetics | volume = 104 | issue = 9 | date = 2025 | article-number = 9 | doi = 10.1007/s12041-025-01497-x | pmid = 40386916 }}</ref><ref>{{cite journal | vauthors = Girirajan S, Elsas LJ, Devriendt K, Elsea SH | title = RAI1 variations in Smith-Magenis syndrome patients without 17p11.2 deletions | journal = Journal of Medical Genetics | volume = 42 | issue = 11 | pages = 820–828 | date = November 2005 | pmid = 15788730 | pmc = 1735950 | doi = 10.1136/jmg.2005.031211 }}</ref> whereas duplications of the gene are associated with Potocki–Lupski syndrome.<ref>{{cite journal | vauthors = Mullegama SV, Alaimo JT, Fountain MD, Burns B, Balog AH, Chen L, Elsea SH | title = <i>RAI1</i> Overexpression Promotes Altered Circadian Gene Expression and Dyssomnia in Potocki-Lupski Syndrome | journal = Journal of Pediatric Genetics | volume = 6 | issue = 3 | pages = 155–164 | date = September 2017 | pmid = 28794907 | pmc = 5548529 | doi = 10.1055/s-0037-1599147 }}</ref>
== See also == * Retinoic acid
== References == {{Reflist}}
== External links == * [https://www.ncbi.nlm.nih.gov/books/NBK1310/ GeneReviews/NIH/NCBI/UW entry on Smith-Magenis Syndrome] * {{MeSH name|RAI1+protein,+human}}
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