RAB25

{{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Ras-related protein Rab-25''' is a protein that in humans is encoded by the ''RAB25'' gene.<ref name="pmid11697911">{{cite journal |vauthors=Pereira-Leal JB, Seabra MC | title = Evolution of the Rab family of small GTP-binding proteins | journal = J Mol Biol | volume = 313 | issue = 4 | pages = 889–901 |date=November 2001 | pmid = 11697911 | doi = 10.1006/jmbi.2001.5072 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RAB25 RAB25, member RAS oncogene family| url = https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=57111}}</ref> It is thought to act as a promoter of tumor development.<ref>{{cite journal|last1=Kessler|first1=D|last2=Gruen|first2=GC|last3=Heider|first3=D|last4=Morgner|first4=J|last5=Reis|first5=H|last6=Schmid|first6=KW|last7=Jendrossek|first7=V|title=The action of small GTPases Rab11 and Rab25 in vesicle trafficking during cell migration.|journal=Cellular Physiology and Biochemistry|date=2012|volume=29|issue=5–6|pages=647–56|pmid=22613965|doi=10.1159/000295249|doi-access=free}}</ref>

==Interactions== RAB25 has been shown to interact with RAB11FIP2<ref name=pmid11495908>{{cite journal |last=Hales |first=C M |author2=Griner R |author3=Hobdy-Henderson K C |author4=Dorn M C |author5=Hardy D |author6=Kumar R |author7=Navarre J |author8=Chan E K |author9=Lapierre L A |author10=Goldenring J R |date=October 2001 |title=Identification and characterization of a family of Rab11-interacting proteins |journal=J. Biol. Chem. |volume=276 |issue=42 |pages=39067–75 | issn = 0021-9258| pmid = 11495908 |doi = 10.1074/jbc.M104831200 |doi-access=free }}</ref><ref name=pmid11481332>{{cite journal |last=Prekeris |first=R |author2=Davies J M |author3=Scheller R H |date=October 2001 |title=Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins |journal=J. Biol. Chem. |volume=276 |issue=42 |pages=38966–70 | issn = 0021-9258| pmid = 11481332 |doi = 10.1074/jbc.M106133200 |doi-access=free }}</ref> and RAB11FIP5.<ref name=pmid11495908/><ref name=pmid11481332/>

==References== {{Reflist}}

==Further reading== {{Refbegin | 2}} *{{cite journal |vauthors=Goldenring JR, Shen KR, Vaughan HD, Modlin IM |title=Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney, and lung. |journal=J. Biol. Chem. |volume=268 |issue= 25 |pages= 18419–22 |year= 1993 |doi=10.1016/S0021-9258(17)46639-7 |pmid= 8360141 |doi-access=free }} *{{cite journal |vauthors=Ray GS, Lee JR, Nwokeji K, etal |title=Increased immunoreactivity for Rab11, a small GTP-binding protein, in low-grade dysplastic Barrett's epithelia. |journal=Lab. Invest. |volume=77 |issue= 5 |pages= 503–11 |year= 1997 |pmid= 9389793 }} *{{cite journal |vauthors=Lapierre LA, Kumar R, Hales CM, etal |title=Myosin vb is associated with plasma membrane recycling systems. |journal=Mol. Biol. Cell |volume=12 |issue= 6 |pages= 1843–57 |year= 2001 |pmid= 11408590 |doi= 10.1091/mbc.12.6.1843| pmc=37346 }} *{{cite journal |vauthors=Prekeris R, Davies JM, Scheller RH |title=Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins. |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 38966–70 |year= 2001 |pmid= 11481332 |doi= 10.1074/jbc.M106133200 |doi-access= free }} *{{cite journal |vauthors=Hales CM, Griner R, Hobdy-Henderson KC, etal |title=Identification and characterization of a family of Rab11-interacting proteins. |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 39067–75 |year= 2001 |pmid= 11495908 |doi= 10.1074/jbc.M104831200 |doi-access= free }} *{{cite journal |vauthors=Suzuki H, Fukunishi Y, Kagawa I, etal |title=Protein-protein interaction panel using mouse full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758–65 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101 | pmc=311163 }} *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} *{{cite journal |vauthors=Barrios-Rodiles M, Brown KR, Ozdamar B, etal |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 |bibcode=2005Sci...307.1621B |s2cid=39457788 }} *{{cite journal |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }} *{{cite journal |vauthors=Fan Y, Xin XY, Chen BL, Ma X |title=Knockdown of RAB25 expression by RNAi inhibits growth of human epithelial ovarian cancer cells in vitro and in vivo. |journal=Pathology |volume=38 |issue= 6 |pages= 561–7 |year= 2007 |pmid= 17393986 |doi=10.1080/00313020601024037 |s2cid=85960469 }} {{Refend}} {{PDB Gallery|geneid=57111}}